SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tgq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GM7_B_PNNB1577_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 3tgq HIV-1 YU2 GP120
(Human
immunodeficiency
virus
1) 		4 / 8 SER A  56
SER A 115
PHE A 210
ILE A 108
 None
 0.94A 1gm7A-3tgqA:
undetectable
1gm7B-3tgqA:
undetectable		 1gm7A-3tgqA:
21.82
1gm7B-3tgqA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_1
(HYPOTHETICAL PROTEIN
RV2118C)		 3tgq HIV-1 YU2 GP120
(Human
immunodeficiency
virus
1) 		3 / 3 GLU A 106
HIS A 105
ASP A 113
 None
 0.88A 1i9gA-3tgqA:
undetectable		 1i9gA-3tgqA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		 3tgq HIV-1 YU2 GP120
(Human
immunodeficiency
virus
1) 		4 / 8 LEU A 483
ILE A 251
HIS A 249
GLY A 263
 None
 0.72A 3b9lA-3tgqA:
undetectable		 3b9lA-3tgqA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U88_A_CHDA611_0
(MENIN)		 3tgq HIV-1 YU2 GP120
(Human
immunodeficiency
virus
1) 		3 / 3 SER A 375
PHE A 382
LYS A 421
 None
 0.95A 3u88A-3tgqA:
undetectable		 3u88A-3tgqA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_1
(METHYLTRANSFERASE
WBDD)		 3tgq HIV-1 YU2 GP120
(Human
immunodeficiency
virus
1) 		3 / 3 GLN A 203
ASP A 113
GLN A 428
 None
 0.80A 4aztA-3tgqA:
undetectable		 4aztA-3tgqA:
17.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)		 3tgq HIV-1 YU2 GP120
(Human
immunodeficiency
virus
1) 		4 / 6 ASP A  57
PRO A 214
HIS A 216
ARG A 252
 None
None
None
NAG  A 502 ( 4.3A)
 0.30A 4lajA-3tgqA:
51.9
4lajB-3tgqA:
51.7		 4lajA-3tgqA:
100.00
4lajB-3tgqA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 3tgq HIV-1 YU2 GP120
(Human
immunodeficiency
virus
1) 		5 / 12 GLN A 352
ILE A 345
LEU A 453
VAL A 286
ILE A 270
 None
None
None
None
NAG  A 504 (-4.4A)
 0.98A 4uw0A-3tgqA:
undetectable		 4uw0A-3tgqA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA610_0
(SERUM ALBUMIN)		 3tgq HIV-1 YU2 GP120
(Human
immunodeficiency
virus
1) 		3 / 3 TYR A 486
LYS A 485
LYS A 227
 None
 1.22A 5dbyA-3tgqA:
undetectable		 5dbyA-3tgqA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JM4_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3tgq HIV-1 YU2 GP120
(Human
immunodeficiency
virus
1) 		4 / 5 PHE A 468
ILE A 359
GLN A 352
ARG A 456
 None
 0.91A 5jm4A-3tgqA:
undetectable		 5jm4A-3tgqA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JM4_B_BEZB301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3tgq HIV-1 YU2 GP120
(Human
immunodeficiency
virus
1) 		4 / 4 PHE A 468
ILE A 359
GLN A 352
ARG A 456
 None
 0.91A 5jm4B-3tgqA:
undetectable		 5jm4B-3tgqA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_A_CCSA14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 3tgq HIV-1 YU2 GP120
(Human
immunodeficiency
virus
1) 		4 / 6 PHE A 468
LEU A 452
ARG A 469
GLY A 471
 None
 1.15A 5o4yA-3tgqA:
undetectable		 5o4yA-3tgqA:
4.85