SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tgw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ACJ_A_THAA999_1
(ACETYLCHOLINESTERASE)		 3tgw V-TYPE ATP SYNTHASE
BETA CHAIN
(Methanosarcina
mazei) 		5 / 9 GLY A 136
PHE A 407
TYR A 375
ILE A 432
GLY A 429
 None
 1.48A 1acjA-3tgwA:
undetectable		 1acjA-3tgwA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_B_FOLB187_0
(DIHYDROFOLATE
REDUCTASE)		 3tgw V-TYPE ATP SYNTHASE
BETA CHAIN
(Methanosarcina
mazei) 		5 / 12 ILE A 302
GLN A 325
ILE A 134
ASN A 138
LEU A 146
 None
 1.20A 1dhfB-3tgwA:
undetectable		 1dhfB-3tgwA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3tgw V-TYPE ATP SYNTHASE
BETA CHAIN
(Methanosarcina
mazei) 		4 / 4 LEU A 436
PRO A 437
LEU A 441
ARG A 443
 None
 1.45A 2pnjB-3tgwA:
undetectable		 2pnjB-3tgwA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA702_0
(FERROCHELATASE)		 3tgw V-TYPE ATP SYNTHASE
BETA CHAIN
(Methanosarcina
mazei) 		3 / 3 LEU A 436
PRO A 437
ARG A 443
 None
 0.65A 2qd5A-3tgwA:
2.2		 2qd5A-3tgwA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		 3tgw V-TYPE ATP SYNTHASE
BETA CHAIN
(Methanosarcina
mazei) 		4 / 5 VAL A 222
VAL A  53
ASP A  46
SER A  48
 None
 1.34A 2x45A-3tgwA:
undetectable		 2x45A-3tgwA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)		 3tgw V-TYPE ATP SYNTHASE
BETA CHAIN
(Methanosarcina
mazei) 		5 / 12 VAL A 367
ALA A 366
ALA A 373
THR A 425
ILE A 355
 None
 1.30A 3dl9B-3tgwA:
undetectable		 3dl9B-3tgwA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3tgw V-TYPE ATP SYNTHASE
BETA CHAIN
(Methanosarcina
mazei) 		3 / 3 ASP A 279
LEU A 280
GLN A 299
 None
 0.66A 3g4lA-3tgwA:
undetectable		 3g4lA-3tgwA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3tgw V-TYPE ATP SYNTHASE
BETA CHAIN
(Methanosarcina
mazei) 		4 / 4 LEU A 436
PRO A 437
LEU A 441
ARG A 443
 None
 1.38A 3hcoA-3tgwA:
undetectable		 3hcoA-3tgwA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_A_PNTA901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 3tgw V-TYPE ATP SYNTHASE
BETA CHAIN
(Methanosarcina
mazei) 		5 / 12 TYR A 252
THR A 282
ASP A 279
SER A  48
ASN A 111
 None
None
None
None
GOL  A 465 ( 3.6A)
 1.43A 3hiiA-3tgwA:
undetectable		 3hiiA-3tgwA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_B_PNTB901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 3tgw V-TYPE ATP SYNTHASE
BETA CHAIN
(Methanosarcina
mazei) 		5 / 12 TYR A 252
THR A 282
ASP A 279
SER A  48
ASN A 111
 None
None
None
None
GOL  A 465 ( 3.6A)
 1.43A 3hiiB-3tgwA:
undetectable		 3hiiB-3tgwA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 3tgw V-TYPE ATP SYNTHASE
BETA CHAIN
(Methanosarcina
mazei) 		5 / 12 ILE A 131
ASP A 135
THR A 129
ILE A 326
PRO A 339
 None
 1.15A 3kpbA-3tgwA:
undetectable		 3kpbA-3tgwA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 3tgw V-TYPE ATP SYNTHASE
BETA CHAIN
(Methanosarcina
mazei) 		5 / 12 ILE A 131
ASP A 135
THR A 129
ILE A 326
PRO A 339
 None
 1.18A 3kpbC-3tgwA:
undetectable		 3kpbC-3tgwA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 3tgw V-TYPE ATP SYNTHASE
BETA CHAIN
(Methanosarcina
mazei) 		5 / 10 ILE A 326
ILE A 300
ASP A 135
ILE A 131
SER A 132
 None
 1.25A 3o1cA-3tgwA:
undetectable		 3o1cA-3tgwA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 3tgw V-TYPE ATP SYNTHASE
BETA CHAIN
(Methanosarcina
mazei) 		4 / 8 ASP A 105
TYR A 233
SER A  81
ASP A  83
 None
 1.01A 4k0bB-3tgwA:
undetectable		 4k0bB-3tgwA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 3tgw V-TYPE ATP SYNTHASE
BETA CHAIN
(Methanosarcina
mazei) 		4 / 8 ASP A 105
TYR A 233
SER A  81
ASP A  83
 None
 1.00A 4l7iB-3tgwA:
undetectable		 4l7iB-3tgwA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB302_1
(CHITOSANASE)		 3tgw V-TYPE ATP SYNTHASE
BETA CHAIN
(Methanosarcina
mazei) 		4 / 5 ARG A 286
THR A 282
ASP A 279
TYR A 252
 None
 1.46A 4oltB-3tgwA:
undetectable		 4oltB-3tgwA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PBH_A_BEZA401_0
(TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE)		 3tgw V-TYPE ATP SYNTHASE
BETA CHAIN
(Methanosarcina
mazei) 		5 / 12 ILE A 249
ALA A 181
ARG A 225
LEU A 283
LEU A 228
 None
 1.32A 4pbhA-3tgwA:
undetectable		 4pbhA-3tgwA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA302_1
(CHITOSANASE)		 3tgw V-TYPE ATP SYNTHASE
BETA CHAIN
(Methanosarcina
mazei) 		4 / 5 ARG A 286
THR A 282
ASP A 279
TYR A 252
 None
 1.43A 4qwpA-3tgwA:
undetectable		 4qwpA-3tgwA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB306_1
(CHITOSANASE)		 3tgw V-TYPE ATP SYNTHASE
BETA CHAIN
(Methanosarcina
mazei) 		4 / 5 ARG A 286
THR A 282
ASP A 279
TYR A 252
 None
 1.47A 4qwpB-3tgwA:
undetectable		 4qwpB-3tgwA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3tgw V-TYPE ATP SYNTHASE
BETA CHAIN
(Methanosarcina
mazei) 		4 / 7 ILE A 321
PRO A 301
ILE A 249
ASP A 248
 None
 1.05A 4w5oA-3tgwA:
undetectable		 4w5oA-3tgwA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3tgw V-TYPE ATP SYNTHASE
BETA CHAIN
(Methanosarcina
mazei) 		4 / 7 ILE A 321
PRO A 301
ILE A 249
ASP A 248
 None
 1.01A 4z4eA-3tgwA:
undetectable		 4z4eA-3tgwA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3tgw V-TYPE ATP SYNTHASE
BETA CHAIN
(Methanosarcina
mazei) 		4 / 7 ILE A 321
PRO A 301
ILE A 249
ASP A 248
 None
 1.02A 4z4gA-3tgwA:
undetectable		 4z4gA-3tgwA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DWK_C_ACTC207_0
(DIACYLGLYCEROL
KINASE)		 3tgw V-TYPE ATP SYNTHASE
BETA CHAIN
(Methanosarcina
mazei) 		4 / 5 GLU A 408
ALA A 404
ASN A 342
GLU A 331
 None
 1.21A 5dwkC-3tgwA:
undetectable		 5dwkC-3tgwA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3tgw V-TYPE ATP SYNTHASE
BETA CHAIN
(Methanosarcina
mazei) 		3 / 3 ASP A 445
LEU A 426
ARG A 361
 None
 0.96A 5e8qA-3tgwA:
undetectable		 5e8qA-3tgwA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_A_ADNA401_1
(ADENOSINE KINASE)		 3tgw V-TYPE ATP SYNTHASE
BETA CHAIN
(Methanosarcina
mazei) 		5 / 12 GLY A  35
THR A  38
ILE A 110
ALA A 114
ALA A 113
 GOL  A 463 (-3.5A)
None
None
GOL  A 463 (-4.2A)
GOL  A 465 ( 3.5A)
 0.85A 5kb6A-3tgwA:
undetectable		 5kb6A-3tgwA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)		 3tgw V-TYPE ATP SYNTHASE
BETA CHAIN
(Methanosarcina
mazei) 		4 / 8 ARG A 257
GLU A 254
GLY A 307
PRO A 306
 None
 1.08A 5kf8A-3tgwA:
undetectable		 5kf8A-3tgwA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3tgw V-TYPE ATP SYNTHASE
BETA CHAIN
(Methanosarcina
mazei) 		3 / 3 TYR A 252
ARG A 220
THR A 223
 None
 0.91A 5z84J-3tgwA:
undetectable		 5z84J-3tgwA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA812_0
(GEPHYRIN)		 3tgw V-TYPE ATP SYNTHASE
BETA CHAIN
(Methanosarcina
mazei) 		4 / 6 GLU A 331
ARG A 379
VAL A 327
PRO A 345
 None
 1.08A 6fgdA-3tgwA:
undetectable		 6fgdA-3tgwA:
24.16