SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3th6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 3th6 TRIOSEPHOSPHATE
ISOMERASE
(Rhipicephalus
microplus) 		5 / 12 ILE A 127
ILE A 113
VAL A 200
LEU A 192
ILE A 147
 None
 0.96A 1df7A-3th6A:
undetectable		 1df7A-3th6A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC6_0
(GRAMICIDIN A)		 3th6 TRIOSEPHOSPHATE
ISOMERASE
(Rhipicephalus
microplus) 		3 / 3 ALA A 198
VAL A 196
TRP A 157
 None
 0.84A 1gmkC-3th6A:
undetectable
1gmkD-3th6A:
undetectable		 1gmkC-3th6A:
5.19
1gmkD-3th6A:
5.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_B_DVAB6_0
(MINI-GRAMICIDIN A)		 3th6 TRIOSEPHOSPHATE
ISOMERASE
(Rhipicephalus
microplus) 		3 / 3 ALA A  63
VAL A  41
TRP A  12
 None
 0.89A 1kqeB-3th6A:
undetectable
1kqeD-3th6A:
undetectable		 1kqeB-3th6A:
7.02
1kqeD-3th6A:
7.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_D_DVAD6_0
(MINI-GRAMICIDIN A)		 3th6 TRIOSEPHOSPHATE
ISOMERASE
(Rhipicephalus
microplus) 		3 / 3 TRP A  12
ALA A  63
VAL A  41
 None
 0.88A 1kqeB-3th6A:
undetectable
1kqeD-3th6A:
undetectable		 1kqeB-3th6A:
7.02
1kqeD-3th6A:
7.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_E_DVAE6_0
(MINI-GRAMICIDIN A)		 3th6 TRIOSEPHOSPHATE
ISOMERASE
(Rhipicephalus
microplus) 		3 / 3 TRP A  12
ALA A  63
VAL A  41
 None
 0.87A 1kqeA-3th6A:
undetectable
1kqeE-3th6A:
undetectable		 1kqeA-3th6A:
7.02
1kqeE-3th6A:
7.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA799_1
(ADENOSINE KINASE)		 3th6 TRIOSEPHOSPHATE
ISOMERASE
(Rhipicephalus
microplus) 		5 / 10 GLY A 209
VAL A 212
ALA A 181
ASN A 216
ILE A 226
 None
 1.05A 1likA-3th6A:
undetectable		 1likA-3th6A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3P_A_ACTA1223_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 15)		 3th6 TRIOSEPHOSPHATE
ISOMERASE
(Rhipicephalus
microplus) 		4 / 5 ASP A 179
THR A 177
GLU A 219
LYS A 223
 None
 1.42A 4a3pA-3th6A:
undetectable		 4a3pA-3th6A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 3th6 TRIOSEPHOSPHATE
ISOMERASE
(Rhipicephalus
microplus) 		3 / 3 ASN A 122
TRP A  90
ASP A 156
 None
 0.68A 4a7tA-3th6A:
undetectable
4a7tF-3th6A:
undetectable		 4a7tA-3th6A:
22.27
4a7tF-3th6A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFG_C_QMRC1214_1
(CAPITELLA TELETA
ACHBP)		 3th6 TRIOSEPHOSPHATE
ISOMERASE
(Rhipicephalus
microplus) 		4 / 8 VAL A 160
CYH A   7
ILE A 162
ILE A 124
 None
 1.02A 4afgD-3th6A:
undetectable
4afgE-3th6A:
undetectable		 4afgD-3th6A:
20.80
4afgE-3th6A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 3th6 TRIOSEPHOSPHATE
ISOMERASE
(Rhipicephalus
microplus) 		5 / 12 GLU A 111
GLY A 110
ILE A 109
ILE A 150
HIS A 149
 None
 1.33A 4xucA-3th6A:
undetectable		 4xucA-3th6A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 3th6 TRIOSEPHOSPHATE
ISOMERASE
(Rhipicephalus
microplus) 		5 / 12 GLU A 111
GLY A 110
ILE A 109
ILE A 150
HIS A 149
 None
 1.33A 4xudA-3th6A:
undetectable		 4xudA-3th6A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		 3th6 TRIOSEPHOSPHATE
ISOMERASE
(Rhipicephalus
microplus) 		4 / 8 SER A 235
GLY A  10
TYR A  47
ALA A  45
 None
 0.71A 5albL-3th6A:
undetectable		 5albL-3th6A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_A_FUAA1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 3th6 TRIOSEPHOSPHATE
ISOMERASE
(Rhipicephalus
microplus) 		4 / 5 ILE A 147
LYS A 114
ILE A 113
VAL A 160
 None
 0.94A 5jmnA-3th6A:
undetectable		 5jmnA-3th6A:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VYH_A_FOLA409_0
(S PROTEIN)		 3th6 TRIOSEPHOSPHATE
ISOMERASE
(Rhipicephalus
microplus) 		5 / 10 PRO A  44
PRO A  46
ALA A  62
GLY A   9
ILE A  40
 None
 1.28A 5vyhA-3th6A:
undetectable		 5vyhA-3th6A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA608_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 3th6 TRIOSEPHOSPHATE
ISOMERASE
(Rhipicephalus
microplus) 		3 / 3 GLY A 137
THR A 139
GLU A 140
 None
 0.56A 6b58A-3th6A:
undetectable		 6b58A-3th6A:
18.03