SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tha'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		 3tha TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Campylobacter
jejuni) 		5 / 12 ILE A  39
ALA A  15
THR A  26
LEU A  31
LEU A 236
 None
 1.18A 1og5B-3thaA:
undetectable		 1og5B-3thaA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		 3tha TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Campylobacter
jejuni) 		5 / 11 PHE A 105
VAL A  46
GLY A  45
VAL A 119
ILE A  97
 None
 1.15A 1phgA-3thaA:
undetectable		 1phgA-3thaA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1217_1
(LIPOPROTEIN LPPX)		 3tha TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Campylobacter
jejuni) 		4 / 4 VAL A  70
LEU A  88
ILE A 114
LEU A 112
 None
 0.98A 2byoA-3thaA:
undetectable		 2byoA-3thaA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		 3tha TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Campylobacter
jejuni) 		4 / 7 THR A  84
ASP A  35
SER A  37
LEU A  19
 None
 1.00A 2hdnE-3thaA:
undetectable
2hdnF-3thaA:
undetectable
2hdnH-3thaA:
3.1		 2hdnE-3thaA:
13.67
2hdnF-3thaA:
23.63
2hdnH-3thaA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		 3tha TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Campylobacter
jejuni) 		4 / 7 SER A  37
LEU A  19
THR A  84
ASP A  35
 None
 0.94A 2hdnF-3thaA:
undetectable
2hdnG-3thaA:
undetectable
2hdnH-3thaA:
3.1		 2hdnF-3thaA:
23.63
2hdnG-3thaA:
13.67
2hdnH-3thaA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_NCAA493_0
(CHORISMATE SYNTHASE)		 3tha TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Campylobacter
jejuni) 		5 / 11 ALA A 109
ILE A  97
ILE A 139
ALA A 116
VAL A  92
 None
 1.09A 2qhfA-3thaA:
undetectable		 2qhfA-3thaA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3tha TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Campylobacter
jejuni) 		5 / 12 ALA A 109
PHE A 105
LEU A  96
CYH A 115
VAL A  92
 None
 1.04A 3rukA-3thaA:
undetectable		 3rukA-3thaA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U88_A_CHDA611_0
(MENIN)		 3tha TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Campylobacter
jejuni) 		3 / 3 SER A  99
PHE A 105
LYS A 104
 None
 0.81A 3u88A-3thaA:
undetectable		 3u88A-3thaA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 3tha TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Campylobacter
jejuni) 		4 / 5 ILE A 131
LYS A 132
GLU A 135
PHE A 124
 None
 1.24A 4ac9C-3thaA:
2.6		 4ac9C-3thaA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3tha TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Campylobacter
jejuni) 		4 / 5 ILE A 131
LYS A 132
GLU A 135
PHE A 124
 None
 1.23A 4acaC-3thaA:
2.7		 4acaC-3thaA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3tha TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Campylobacter
jejuni) 		4 / 5 ILE A 131
LYS A 132
GLU A 135
PHE A 124
 None
 1.24A 4acbC-3thaA:
2.6		 4acbC-3thaA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_B_ECNB403_1
(FLAVOHEMOGLOBIN)		 3tha TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Campylobacter
jejuni) 		5 / 11 ILE A 114
ALA A  80
LEU A  79
VAL A  75
TYR A 100
 None
 1.11A 4g1bB-3thaA:
undetectable		 4g1bB-3thaA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 3tha TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Campylobacter
jejuni) 		5 / 12 VAL A 217
LEU A 184
VAL A 221
ILE A 205
GLY A 204
 None
 0.88A 4y8wC-3thaA:
undetectable		 4y8wC-3thaA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_1
(SCRFP-TAG,GP41)		 3tha TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Campylobacter
jejuni) 		5 / 12 GLY A 172
SER A 170
LYS A 177
GLU A 180
LEU A 184
 None
 1.15A 5nwvA-3thaA:
undetectable		 5nwvA-3thaA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSP_A_ACTA403_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 3tha TRYPTOPHAN SYNTHASE
ALPHA CHAIN
(Campylobacter
jejuni) 		4 / 7 VAL A 201
ILE A 199
VAL A 217
ALA A 218
 None
 0.73A 5ospA-3thaA:
undetectable		 5ospA-3thaA:
19.66