SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3thc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3thc BETA-GALACTOSIDASE
(Homo
sapiens) 		3 / 3 GLU A 478
TYR A 316
PHE A 415
 None
 0.86A 1eqbB-3thcA:
undetectable		 1eqbB-3thcA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3thc BETA-GALACTOSIDASE
(Homo
sapiens) 		3 / 3 GLU A 478
TYR A 316
PHE A 415
 None
 0.84A 1eqbA-3thcA:
undetectable		 1eqbA-3thcA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3thc BETA-GALACTOSIDASE
(Homo
sapiens) 		3 / 3 GLU A 478
TYR A 316
PHE A 415
 None
 0.85A 1eqbD-3thcA:
undetectable		 1eqbD-3thcA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3thc BETA-GALACTOSIDASE
(Homo
sapiens) 		3 / 3 GLU A 478
TYR A 316
PHE A 415
 None
 0.84A 1eqbC-3thcA:
undetectable		 1eqbC-3thcA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA652_1
(AMYLOMALTASE)		 3thc BETA-GALACTOSIDASE
(Homo
sapiens) 		4 / 6 TYR A 331
GLY A 310
GLY A 272
SER A  54
 None
None
None
CL  A 801 (-3.0A)
 0.73A 1eswA-3thcA:
11.5		 1eswA-3thcA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXH_B_PACB1001_0
(PENICILLIN ACYLASE)		 3thc BETA-GALACTOSIDASE
(Homo
sapiens) 		4 / 7 SER A 302
PHE A  48
SER A  52
ILE A 119
 None
 0.87A 1fxhA-3thcA:
undetectable
1fxhB-3thcA:
undetectable		 1fxhA-3thcA:
15.02
1fxhB-3thcA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GM7_B_PNNB1577_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 3thc BETA-GALACTOSIDASE
(Homo
sapiens) 		4 / 8 SER A 302
PHE A  48
SER A  52
ILE A 119
 None
 0.89A 1gm7A-3thcA:
undetectable
1gm7B-3thcA:
undetectable		 1gm7A-3thcA:
15.02
1gm7B-3thcA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IA0_B_TXLB502_1
(TUBULIN BETA CHAIN)		 3thc BETA-GALACTOSIDASE
(Homo
sapiens) 		5 / 12 VAL A 158
LEU A 233
PHE A 207
THR A 219
PRO A 122
 None
 1.40A 1ia0B-3thcA:
1.8		 1ia0B-3thcA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI518_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3thc BETA-GALACTOSIDASE
(Homo
sapiens) 		4 / 7 ILE A 607
PRO A  61
PHE A 314
ASN A 587
 None
 0.95A 1oniG-3thcA:
undetectable
1oniI-3thcA:
undetectable		 1oniG-3thcA:
11.97
1oniI-3thcA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PNL_B_PACB559_0
(PENICILLIN
AMIDOHYDROLASE)		 3thc BETA-GALACTOSIDASE
(Homo
sapiens) 		4 / 8 SER A 302
PHE A  48
SER A  52
ILE A 119
 None
 0.85A 1pnlA-3thcA:
undetectable
1pnlB-3thcA:
undetectable		 1pnlA-3thcA:
15.02
1pnlB-3thcA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3thc BETA-GALACTOSIDASE
(Homo
sapiens) 		5 / 10 GLY A 494
VAL A 439
GLY A 438
THR A 405
VAL A 477
 None
 1.10A 1pwyE-3thcA:
undetectable		 1pwyE-3thcA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_D_NCAD349_0
(ADP-RIBOSYL CYCLASE)		 3thc BETA-GALACTOSIDASE
(Homo
sapiens) 		3 / 3 GLU A 131
ASN A  87
TRP A 317
 None
None
EDO  A1102 (-3.2A)
 1.27A 1r15D-3thcA:
2.3		 1r15D-3thcA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3thc BETA-GALACTOSIDASE
(Homo
sapiens) 		5 / 12 LEU A 108
PHE A 107
SER A  52
ILE A  80
LEU A  69
 None
 1.31A 1rh3A-3thcA:
undetectable		 1rh3A-3thcA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUB_B_TXLB501_1
(TUBULIN)		 3thc BETA-GALACTOSIDASE
(Homo
sapiens) 		5 / 12 VAL A 158
LEU A 233
PHE A 207
THR A 219
PRO A 122
 None
 1.40A 1tubB-3thcA:
3.3		 1tubB-3thcA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3thc BETA-GALACTOSIDASE
(Homo
sapiens) 		5 / 10 GLY A 494
VAL A 439
GLY A 438
THR A 405
VAL A 477
 None
 1.13A 1v3qE-3thcA:
undetectable		 1v3qE-3thcA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3thc BETA-GALACTOSIDASE
(Homo
sapiens) 		5 / 12 GLY A 494
GLY A 438
GLN A 411
PHE A 415
ASP A 441
 None
 1.11A 1wg8B-3thcA:
undetectable		 1wg8B-3thcA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMQ_A_BEZA3_0
(PROTEIN NDRG2)		 3thc BETA-GALACTOSIDASE
(Homo
sapiens) 		4 / 7 TYR A 306
TYR A  83
GLN A  81
HIS A  56
 GAL  A 900 (-4.6A)
CL  A 801 (-4.2A)
CL  A 801 ( 4.6A)
CL  A 801 (-4.4A)
 1.42A 2qmqA-3thcA:
undetectable		 2qmqA-3thcA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3thc BETA-GALACTOSIDASE
(Homo
sapiens) 		4 / 8 TYR A 306
TYR A 331
SER A 330
ILE A 309
 GAL  A 900 (-4.6A)
None
None
None
 1.08A 2xz5B-3thcA:
undetectable
2xz5E-3thcA:
undetectable		 2xz5B-3thcA:
15.70
2xz5E-3thcA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		 3thc BETA-GALACTOSIDASE
(Homo
sapiens) 		4 / 8 ALA A 290
LEU A 293
GLN A 355
ILE A 365
 None
None
SO4  A1001 (-3.1A)
None
 0.80A 3cldB-3thcA:
undetectable		 3cldB-3thcA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE201_1
(PROTEIN S100-A4)		 3thc BETA-GALACTOSIDASE
(Homo
sapiens) 		4 / 7 PHE A 269
GLY A 243
PHE A 242
PHE A 252
 None
EDO  A1101 (-3.2A)
None
None
 0.94A 3ko0D-3thcA:
undetectable
3ko0E-3thcA:
undetectable		 3ko0D-3thcA:
10.22
3ko0E-3thcA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN201_1
(PROTEIN S100-A4)		 3thc BETA-GALACTOSIDASE
(Homo
sapiens) 		5 / 10 PHE A 269
GLY A 243
PHE A 242
GLY A 272
PHE A 252
 None
EDO  A1101 (-3.2A)
None
None
None
 1.45A 3ko0L-3thcA:
undetectable
3ko0N-3thcA:
undetectable		 3ko0L-3thcA:
10.22
3ko0N-3thcA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_R_TFPR201_1
(PROTEIN S100-A4)		 3thc BETA-GALACTOSIDASE
(Homo
sapiens) 		5 / 10 GLY A 272
PHE A 252
PHE A 269
GLY A 243
PHE A 242
 None
None
None
EDO  A1101 (-3.2A)
None
 1.48A 3ko0R-3thcA:
undetectable
3ko0T-3thcA:
undetectable		 3ko0R-3thcA:
10.22
3ko0T-3thcA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZV_B_ECNB411_1
(FLAVOHEMOGLOBIN)		 3thc BETA-GALACTOSIDASE
(Homo
sapiens) 		5 / 9 ILE A 354
ILE A 353
ALA A 298
LEU A 297
LEU A 305
 None
 0.96A 3ozvB-3thcA:
undetectable		 3ozvB-3thcA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 3thc BETA-GALACTOSIDASE
(Homo
sapiens) 		4 / 7 ASN A  78
GLY A  76
ILE A 353
LEU A 297
 None
 0.63A 4ejjD-3thcA:
undetectable		 4ejjD-3thcA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA304_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 3thc BETA-GALACTOSIDASE
(Homo
sapiens) 		3 / 3 ARG A  59
HIS A  56
TYR A 331
 None
CL  A 801 (-4.4A)
None
 1.32A 4fu8A-3thcA:
undetectable		 4fu8A-3thcA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_A_IMNA201_1
(TRANSTHYRETIN)		 3thc BETA-GALACTOSIDASE
(Homo
sapiens) 		4 / 7 LEU A 633
THR A 637
ALA A 635
THR A 378
 None
 0.72A 4ik7A-3thcA:
undetectable		 4ik7A-3thcA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		 3thc BETA-GALACTOSIDASE
(Homo
sapiens) 		4 / 6 ASP A 518
ASN A 587
TYR A 413
ASP A 515
 None
None
EDO  A1102 (-3.5A)
None
 1.10A 4mdbA-3thcA:
undetectable		 4mdbA-3thcA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3thc BETA-GALACTOSIDASE
(Homo
sapiens) 		4 / 6 VAL A 520
LEU A 524
LEU A 619
PHE A 406
 None
 1.12A 4o1zA-3thcA:
undetectable		 4o1zA-3thcA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 3thc BETA-GALACTOSIDASE
(Homo
sapiens) 		5 / 12 ALA A 315
GLN A 580
LEU A 588
GLY A 585
ASP A 518
 EDO  A1102 (-3.3A)
None
None
None
None
 1.11A 4pclA-3thcA:
2.0		 4pclA-3thcA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB305_1
(CHITOSANASE)		 3thc BETA-GALACTOSIDASE
(Homo
sapiens) 		3 / 3 GLY A 262
PRO A 263
GLN A 255
 None
 0.46A 4qwpB-3thcA:
undetectable		 4qwpB-3thcA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 3thc BETA-GALACTOSIDASE
(Homo
sapiens) 		3 / 3 GLU A 268
TYR A 331
GLU A 129
 GAL  A 900 (-2.5A)
None
GAL  A 900 (-2.8A)
 0.77A 4ryaA-3thcA:
undetectable		 4ryaA-3thcA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIN_H_QI9H1226_0
(FAB 314.3)		 3thc BETA-GALACTOSIDASE
(Homo
sapiens) 		5 / 12 TRP A 582
THR A 516
GLY A 585
GLY A 526
LEU A 524
 None
 1.29A 4uinH-3thcA:
undetectable
4uinL-3thcA:
undetectable		 4uinH-3thcA:
16.41
4uinL-3thcA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_1
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 3thc BETA-GALACTOSIDASE
(Homo
sapiens) 		4 / 6 ASN A 318
GLU A 478
LYS A 578
TYR A 324
 None
 1.18A 4wcxC-3thcA:
10.0		 4wcxC-3thcA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)		 3thc BETA-GALACTOSIDASE
(Homo
sapiens) 		4 / 5 ARG A 148
GLY A 123
GLU A 186
SER A  58
 None
 1.24A 4z3oA-3thcA:
undetectable
4z3oB-3thcA:
undetectable		 4z3oA-3thcA:
21.63
4z3oB-3thcA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_ACTA605_0
(SERUM ALBUMIN)		 3thc BETA-GALACTOSIDASE
(Homo
sapiens) 		4 / 6 TYR A  83
GLY A 123
GLU A 186
ASN A 187
 CL  A 801 (-4.2A)
None
None
GAL  A 900 (-3.2A)
 1.20A 4zbqA-3thcA:
undetectable		 4zbqA-3thcA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSM_A_GCSA801_1
(EXO-BETA-D-GLUCOSAMI
NIDASE)		 3thc BETA-GALACTOSIDASE
(Homo
sapiens) 		6 / 12 TYR A  83
CYH A 127
GLU A 129
GLU A 188
GLU A 268
TYR A 306
 CL  A 801 (-4.2A)
GAL  A 900 (-3.3A)
GAL  A 900 (-2.8A)
GAL  A 900 (-2.5A)
GAL  A 900 (-2.5A)
GAL  A 900 (-4.6A)
 0.71A 5gsmA-3thcA:
32.4		 5gsmA-3thcA:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSM_B_GCSB801_1
(EXO-BETA-D-GLUCOSAMI
NIDASE)		 3thc BETA-GALACTOSIDASE
(Homo
sapiens) 		6 / 12 TYR A  83
CYH A 127
GLU A 129
GLU A 188
GLU A 268
TYR A 306
 CL  A 801 (-4.2A)
GAL  A 900 (-3.3A)
GAL  A 900 (-2.8A)
GAL  A 900 (-2.5A)
GAL  A 900 (-2.5A)
GAL  A 900 (-4.6A)
 0.71A 5gsmB-3thcA:
33.2		 5gsmB-3thcA:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_A_BEZA301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 3thc BETA-GALACTOSIDASE
(Homo
sapiens) 		5 / 10 GLY A 579
LEU A 619
LEU A 476
GLU A 478
TYR A 444
 None
 1.13A 5hwkA-3thcA:
undetectable		 5hwkA-3thcA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWK_B_BEZB301_0
(GLUTATHIONE-SPECIFIC
GAMMA-GLUTAMYLCYCLOT
RANSFERASE)		 3thc BETA-GALACTOSIDASE
(Homo
sapiens) 		5 / 10 GLY A 579
LEU A 619
LEU A 476
GLU A 478
TYR A 444
 None
 1.12A 5hwkB-3thcA:
undetectable		 5hwkB-3thcA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3thc BETA-GALACTOSIDASE
(Homo
sapiens) 		5 / 12 ALA A 443
TYR A 444
GLY A 481
GLY A 494
LEU A 495
 None
 0.99A 5i73A-3thcA:
undetectable		 5i73A-3thcA:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3thc BETA-GALACTOSIDASE
(Homo
sapiens) 		4 / 6 PHE A  63
PRO A 604
ARG A  68
THR A 369
 None
 1.36A 5ih0A-3thcA:
undetectable		 5ih0A-3thcA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OAJ_E_TKTE601_1
()		 3thc BETA-GALACTOSIDASE
(Homo
sapiens) 		4 / 8 GLU A 129
TRP A 273
TYR A 485
TYR A 270
 GAL  A 900 (-2.8A)
GAL  A 900 ( 4.9A)
None
None
 1.20A 5oajD-3thcA:
0.0
5oajE-3thcA:
0.0		 5oajD-3thcA:
16.80
5oajE-3thcA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODH_G_ACTG710_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 3thc BETA-GALACTOSIDASE
(Homo
sapiens) 		4 / 4 ARG A 121
ILE A 119
TYR A  50
ILE A 265
 CL  A 801 (-4.1A)
None
None
None
 1.20A 5odhG-3thcA:
2.3		 5odhG-3thcA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGN_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3thc BETA-GALACTOSIDASE
(Homo
sapiens) 		3 / 3 VAL A 180
VAL A 118
GLN A  81
 None
None
CL  A 801 ( 4.6A)
 0.65A 5qgnA-3thcA:
undetectable		 5qgnA-3thcA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGY_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3thc BETA-GALACTOSIDASE
(Homo
sapiens) 		3 / 3 VAL A 180
VAL A 118
GLN A  81
 None
None
CL  A 801 ( 4.6A)
 0.65A 5qgyA-3thcA:
undetectable		 5qgyA-3thcA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGZ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3thc BETA-GALACTOSIDASE
(Homo
sapiens) 		3 / 3 VAL A 180
VAL A 118
GLN A  81
 None
None
CL  A 801 ( 4.6A)
 0.66A 5qgzA-3thcA:
undetectable		 5qgzA-3thcA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH0_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3thc BETA-GALACTOSIDASE
(Homo
sapiens) 		3 / 3 VAL A 180
VAL A 118
GLN A  81
 None
None
CL  A 801 ( 4.6A)
 0.68A 5qh0A-3thcA:
undetectable		 5qh0A-3thcA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH2_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3thc BETA-GALACTOSIDASE
(Homo
sapiens) 		3 / 3 VAL A 180
VAL A 118
GLN A  81
 None
None
CL  A 801 ( 4.6A)
 0.65A 5qh2A-3thcA:
undetectable		 5qh2A-3thcA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH3_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3thc BETA-GALACTOSIDASE
(Homo
sapiens) 		3 / 3 VAL A 180
VAL A 118
GLN A  81
 None
None
CL  A 801 ( 4.6A)
 0.66A 5qh3A-3thcA:
undetectable		 5qh3A-3thcA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH5_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3thc BETA-GALACTOSIDASE
(Homo
sapiens) 		3 / 3 VAL A 180
VAL A 118
GLN A  81
 None
None
CL  A 801 ( 4.6A)
 0.63A 5qh5A-3thcA:
undetectable		 5qh5A-3thcA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH6_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3thc BETA-GALACTOSIDASE
(Homo
sapiens) 		3 / 3 VAL A 180
VAL A 118
GLN A  81
 None
None
CL  A 801 ( 4.6A)
 0.68A 5qh6A-3thcA:
undetectable		 5qh6A-3thcA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH7_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3thc BETA-GALACTOSIDASE
(Homo
sapiens) 		3 / 3 VAL A 180
VAL A 118
GLN A  81
 None
None
CL  A 801 ( 4.6A)
 0.66A 5qh7A-3thcA:
undetectable		 5qh7A-3thcA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHH_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3thc BETA-GALACTOSIDASE
(Homo
sapiens) 		3 / 3 VAL A 180
VAL A 118
GLN A  81
 None
None
CL  A 801 ( 4.6A)
 0.67A 5qhhA-3thcA:
undetectable		 5qhhA-3thcA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_1
(CYTOCHROME P450 2C9)		 3thc BETA-GALACTOSIDASE
(Homo
sapiens) 		5 / 12 ALA A 111
GLY A  76
ALA A  75
LEU A 343
LEU A 337
 None
 1.20A 5x23A-3thcA:
undetectable		 5x23A-3thcA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_B_P2EB1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 3thc BETA-GALACTOSIDASE
(Homo
sapiens) 		4 / 5 PRO A 513
VAL A 409
GLY A 481
VAL A 477
 None
 1.00A 6ak3B-3thcA:
undetectable		 6ak3B-3thcA:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_B_SAMB505_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 3thc BETA-GALACTOSIDASE
(Homo
sapiens) 		5 / 12 GLY A 133
ILE A 489
TYR A 192
TYR A 154
LEU A 139
 None
 1.40A 6bp4B-3thcA:
undetectable		 6bp4B-3thcA:
19.03