SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3thn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGS_A_SALA256_1
(MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR)		 3thn EXONUCLEASE,
PUTATIVE
(Thermotoga
maritima) 		4 / 7 VAL A  87
LEU A  55
THR A  12
VAL A  50
 None
 0.99A 1jgsA-3thnA:
undetectable		 1jgsA-3thnA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 3thn EXONUCLEASE,
PUTATIVE
(Thermotoga
maritima) 		4 / 8 ILE A 230
ASP A  14
GLY A 233
PHE A 220
 None
MN  A 360 (-3.4A)
None
None
 0.76A 1rtsA-3thnA:
undetectable		 1rtsA-3thnA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 3thn EXONUCLEASE,
PUTATIVE
(Thermotoga
maritima) 		4 / 7 ILE A 230
ASP A  14
GLY A 233
PHE A 220
 None
MN  A 360 (-3.4A)
None
None
 0.78A 1rtsB-3thnA:
undetectable		 1rtsB-3thnA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 3thn EXONUCLEASE,
PUTATIVE
(Thermotoga
maritima) 		4 / 5 ASP A  14
SER A  13
LEU A 214
GLY A 215
 MN  A 360 (-3.4A)
None
None
None
 1.19A 2j2pA-3thnA:
undetectable
2j2pB-3thnA:
undetectable		 2j2pA-3thnA:
19.76
2j2pB-3thnA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_A_D16A309_1
(THYMIDYLATE SYNTHASE)		 3thn EXONUCLEASE,
PUTATIVE
(Thermotoga
maritima) 		4 / 7 ILE A 230
ASP A  14
GLY A 233
PHE A 220
 None
MN  A 360 (-3.4A)
None
None
 0.79A 2tsrA-3thnA:
undetectable		 2tsrA-3thnA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_A_J01A500_1
(ORF12)		 3thn EXONUCLEASE,
PUTATIVE
(Thermotoga
maritima) 		5 / 10 HIS A  16
ILE A 236
LEU A  60
LEU A  34
GLY A  18
 MN  A 360 (-3.9A)
None
None
None
None
 1.14A 2xf3A-3thnA:
undetectable		 2xf3A-3thnA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3thn EXONUCLEASE,
PUTATIVE
(Thermotoga
maritima) 		3 / 3 ASP A  39
ARG A  31
LYS A  35
 None
 0.97A 3wipG-3thnA:
undetectable		 3wipG-3thnA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_C_ECNC403_1
(FLAVOHEMOGLOBIN)		 3thn EXONUCLEASE,
PUTATIVE
(Thermotoga
maritima) 		5 / 9 ILE A 176
LEU A  54
VAL A  88
VAL A  50
LEU A  52
 None
 1.12A 4g1bC-3thnA:
undetectable		 4g1bC-3thnA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_A_D16A401_1
(ORF70)		 3thn EXONUCLEASE,
PUTATIVE
(Thermotoga
maritima) 		4 / 7 ILE A 230
ASP A  14
GLY A 233
PHE A 220
 None
MN  A 360 (-3.4A)
None
None
 0.86A 5h3aA-3thnA:
undetectable		 5h3aA-3thnA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_B_D16B401_1
(ORF70)		 3thn EXONUCLEASE,
PUTATIVE
(Thermotoga
maritima) 		4 / 7 ILE A 230
ASP A  14
GLY A 233
PHE A 220
 None
MN  A 360 (-3.4A)
None
None
 0.85A 5h3aB-3thnA:
undetectable		 5h3aB-3thnA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 3thn EXONUCLEASE,
PUTATIVE
(Thermotoga
maritima) 		4 / 6 PHE A 119
GLU A 144
PHE A 153
GLU A 197
 None
 1.40A 5h4dA-3thnA:
undetectable		 5h4dA-3thnA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 3thn EXONUCLEASE,
PUTATIVE
(Thermotoga
maritima) 		4 / 6 PHE A 137
GLU A 144
PHE A 153
GLU A 197
 None
 1.36A 5h4dA-3thnA:
undetectable		 5h4dA-3thnA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 3thn EXONUCLEASE,
PUTATIVE
(Thermotoga
maritima) 		4 / 7 ILE A 230
ASP A  14
GLY A 233
PHE A 220
 None
MN  A 360 (-3.4A)
None
None
 0.83A 5nooA-3thnA:
undetectable		 5nooA-3thnA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_B_EZLB303_1
(ALPHA-CARBONIC
ANHYDRASE)		 3thn EXONUCLEASE,
PUTATIVE
(Thermotoga
maritima) 		5 / 9 HIS A  11
VAL A 252
VAL A 250
LEU A 228
ALA A 212
 None
 1.48A 5tt3B-3thnA:
undetectable		 5tt3B-3thnA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 3thn EXONUCLEASE,
PUTATIVE
(Thermotoga
maritima) 		5 / 12 PRO A 232
GLY A 248
LYS A 247
ILE A 223
ASP A 245
 None
 1.11A 5wwsB-3thnA:
undetectable		 5wwsB-3thnA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 3thn EXONUCLEASE,
PUTATIVE
(Thermotoga
maritima) 		4 / 7 ILE A 230
ASP A  14
GLY A 233
PHE A 220
 None
MN  A 360 (-3.4A)
None
None
 0.73A 5x5qC-3thnA:
undetectable		 5x5qC-3thnA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 3thn EXONUCLEASE,
PUTATIVE
(Thermotoga
maritima) 		4 / 8 ILE A 230
ASP A  14
GLY A 233
PHE A 220
 None
MN  A 360 (-3.4A)
None
None
 0.71A 5x5qD-3thnA:
undetectable		 5x5qD-3thnA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_F_D16F402_1
(THYMIDYLATE SYNTHASE)		 3thn EXONUCLEASE,
PUTATIVE
(Thermotoga
maritima) 		4 / 8 ILE A 230
ASP A  14
GLY A 233
PHE A 220
 None
MN  A 360 (-3.4A)
None
None
 0.71A 5x5qF-3thnA:
undetectable		 5x5qF-3thnA:
21.99