SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tht'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EA1_A_TPFA470_1
(CYTOCHROME P450
51-LIKE RV0764C)		 3tht ALKYLATED DNA REPAIR
PROTEIN ALKB HOMOLOG
8
(Homo
sapiens) 		4 / 8 PHE A 333
MET A 224
THR A 329
LEU A 254
 None
 1.28A 1ea1A-3thtA:
undetectable		 1ea1A-3thtA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_1
(HYPOTHETICAL PROTEIN
PH0226)		 3tht ALKYLATED DNA REPAIR
PROTEIN ALKB HOMOLOG
8
(Homo
sapiens) 		4 / 4 TYR A 229
ARG A 328
ASP A 240
ASP A 247
 AKG  A 403 (-4.4A)
AKG  A 403 (-3.2A)
MN  A 402 ( 2.6A)
None
 1.28A 1ve3A-3thtA:
0.0		 1ve3A-3thtA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_B_SAMB301_1
(HYPOTHETICAL PROTEIN
PH0226)		 3tht ALKYLATED DNA REPAIR
PROTEIN ALKB HOMOLOG
8
(Homo
sapiens) 		4 / 4 TYR A 229
ARG A 328
ASP A 240
ASP A 247
 AKG  A 403 (-4.4A)
AKG  A 403 (-3.2A)
MN  A 402 ( 2.6A)
None
 1.29A 1ve3B-3thtA:
0.0		 1ve3B-3thtA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 3tht ALKYLATED DNA REPAIR
PROTEIN ALKB HOMOLOG
8
(Homo
sapiens) 		5 / 11 LEU A  30
LEU A  29
PRO A  78
ASN A  79
LEU A 117
 None
 1.18A 2ft9A-3thtA:
undetectable		 2ft9A-3thtA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VJ1_A_BEZA1303_0
(SARS CORONAVIRUS
MAIN PROTEINASE)		 3tht ALKYLATED DNA REPAIR
PROTEIN ALKB HOMOLOG
8
(Homo
sapiens) 		3 / 3 HIS A 292
MET A 282
MET A 260
 MN  A 402 ( 3.6A)
None
AKG  A 403 (-4.7A)
 1.36A 2vj1A-3thtA:
undetectable		 2vj1A-3thtA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 3tht ALKYLATED DNA REPAIR
PROTEIN ALKB HOMOLOG
8
(Homo
sapiens) 		4 / 7 ASN A 227
ASP A 240
ILE A 235
HIS A 292
 AKG  A 403 (-3.2A)
MN  A 402 ( 2.6A)
AKG  A 403 (-4.4A)
MN  A 402 ( 3.6A)
 1.03A 3t01A-3thtA:
undetectable		 3t01A-3thtA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 3tht ALKYLATED DNA REPAIR
PROTEIN ALKB HOMOLOG
8
(Homo
sapiens) 		4 / 4 ASN A  49
SER A  93
LEU A  45
THR A 114
 None
 1.45A 4an2A-3thtA:
undetectable		 4an2A-3thtA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3tht ALKYLATED DNA REPAIR
PROTEIN ALKB HOMOLOG
8
(Homo
sapiens) 		4 / 8 ILE A 144
PRO A 221
VAL A 250
MET A 224
 None
 1.07A 4f4dB-3thtA:
undetectable		 4f4dB-3thtA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3tht ALKYLATED DNA REPAIR
PROTEIN ALKB HOMOLOG
8
(Homo
sapiens) 		4 / 7 LEU A 152
ARG A 328
PRO A 221
VAL A 250
 None
AKG  A 403 (-3.2A)
None
None
 1.20A 4klrA-3thtA:
undetectable		 4klrA-3thtA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3tht ALKYLATED DNA REPAIR
PROTEIN ALKB HOMOLOG
8
(Homo
sapiens) 		4 / 7 SER A 330
ASP A 300
ARG A 297
GLY A 232
 AKG  A 403 (-3.4A)
None
None
None
 0.83A 5btfA-3thtA:
2.7
5btfC-3thtA:
2.6
5btfD-3thtA:
undetectable		 5btfA-3thtA:
20.70
5btfC-3thtA:
20.70
5btfD-3thtA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3tht ALKYLATED DNA REPAIR
PROTEIN ALKB HOMOLOG
8
(Homo
sapiens) 		4 / 6 SER A 330
ASP A 300
ARG A 297
GLY A 232
 AKG  A 403 (-3.4A)
None
None
None
 1.07A 5cdqA-3thtA:
2.5
5cdqC-3thtA:
2.2
5cdqD-3thtA:
undetectable		 5cdqA-3thtA:
20.77
5cdqC-3thtA:
20.77
5cdqD-3thtA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 3tht ALKYLATED DNA REPAIR
PROTEIN ALKB HOMOLOG
8
(Homo
sapiens) 		3 / 3 GLY A 110
ASP A 107
ASN A  49
 None
 0.62A 5jglA-3thtA:
undetectable		 5jglA-3thtA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DCH_A_ACTA401_0
(SCOE PROTEIN)		 3tht ALKYLATED DNA REPAIR
PROTEIN ALKB HOMOLOG
8
(Homo
sapiens) 		4 / 5 HIS A 238
ASP A 240
HIS A 292
ARG A 334
 MN  A 402 ( 3.8A)
MN  A 402 ( 2.6A)
MN  A 402 ( 3.6A)
AKG  A 403 (-3.9A)
 1.18A 6dchA-3thtA:
5.6		 6dchA-3thtA:
23.54