SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3thw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_B_SALB4005_1
(XANTHINE
DEHYDROGENASE)		 3thw DNA MISMATCH REPAIR
PROTEIN MSH3
(Homo
sapiens) 		4 / 7 GLU B 580
THR B 661
VAL B 662
ALA B 583
 None
 0.75A 1fo4B-3thwB:
2.8		 1fo4B-3thwB:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2503_0
(FERROCHELATASE)		 3thw DNA MISMATCH REPAIR
PROTEIN MSH3
(Homo
sapiens) 		4 / 4 LEU B 419
PRO B 420
LEU B 423
ARG B 402
 None
 1.22A 1hrkB-3thwB:
undetectable		 1hrkB-3thwB:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_A_RBFA100_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 3thw DNA MISMATCH REPAIR
PROTEIN MSH3
(Homo
sapiens) 		5 / 11 SER B 961
LEU B 995
ILE B 850
THR B 873
VAL B 900
 None
 1.21A 1pkvA-3thwB:
undetectable
1pkvB-3thwB:
undetectable		 1pkvA-3thwB:
7.31
1pkvB-3thwB:
7.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA502_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 3thw DNA MISMATCH REPAIR
PROTEIN MSH3
(Homo
sapiens) 		3 / 3 LEU B 239
HIS B 234
LYS B 231
 None
 1.12A 1y7iA-3thwB:
undetectable		 1y7iA-3thwB:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3thw DNA MISMATCH REPAIR
PROTEIN MSH3
(Homo
sapiens) 		5 / 12 LYS B 231
GLY B 251
ASP B 253
ALA B 254
ALA B 258
 None
 1.24A 2br4B-3thwB:
undetectable		 2br4B-3thwB:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3thw DNA MISMATCH REPAIR
PROTEIN MSH3
(Homo
sapiens) 		5 / 12 LYS B 231
GLY B 251
CYH B 265
ASP B 253
ALA B 254
 None
 1.27A 2br4B-3thwB:
undetectable		 2br4B-3thwB:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA703_0
(FERROCHELATASE)		 3thw DNA MISMATCH REPAIR
PROTEIN MSH3
(Homo
sapiens) 		4 / 4 LEU B 419
PRO B 420
LEU B 423
ARG B 402
 None
 1.41A 2hrcA-3thwB:
undetectable		 2hrcA-3thwB:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1604_0
(FERROCHELATASE)		 3thw DNA MISMATCH REPAIR
PROTEIN MSH3
(Homo
sapiens) 		4 / 4 LEU B 419
PRO B 420
LEU B 423
ARG B 402
 None
 1.24A 2hrcB-3thwB:
undetectable		 2hrcB-3thwB:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_B_017B203_1
(HIV-1 PROTEASE)		 3thw DNA MISMATCH REPAIR
PROTEIN MSH3
(Homo
sapiens) 		4 / 7 GLU B 864
PRO B 856
ARG B 854
GLY B 863
 None
 1.16A 2hs1B-3thwB:
undetectable		 2hs1B-3thwB:
8.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3thw DNA MISMATCH REPAIR
PROTEIN MSH3
(Homo
sapiens) 		4 / 4 LEU B 419
PRO B 420
LEU B 423
ARG B 402
 None
 1.30A 2pnjB-3thwB:
undetectable		 2pnjB-3thwB:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)		 3thw DNA MISMATCH REPAIR
PROTEIN MSH3
(Homo
sapiens) 		5 / 11 THR B 928
ILE B 528
LEU B 902
LEU B 533
PRO B 574
 None
 1.28A 3a50B-3thwB:
undetectable		 3a50B-3thwB:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_A_TMQA611_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3thw DNA MISMATCH REPAIR
PROTEIN MSH3
(Homo
sapiens) 		5 / 10 ALA B 918
ILE B 920
ILE B 909
PRO B 574
LEU B 555
 None
 1.13A 3hbbA-3thwB:
undetectable		 3hbbA-3thwB:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3007_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3thw DNA MISMATCH REPAIR
PROTEIN MSH3
(Homo
sapiens) 		5 / 9 ALA B 583
LEU B 585
ALA B 587
SER B 589
ARG B 839
 None
 1.27A 3kp6B-3thwB:
undetectable		 3kp6B-3thwB:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_B_PZIB802_0
(GLUTAMATE RECEPTOR 2)		 3thw DNA MISMATCH REPAIR
PROTEIN MSH3
(Homo
sapiens) 		3 / 3 SER B 403
ASP B 398
ASN B 376
 None
 1.01A 3lsfB-3thwB:
undetectable
3lsfE-3thwB:
undetectable		 3lsfB-3thwB:
14.68
3lsfE-3thwB:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE802_0
(GLUTAMATE RECEPTOR 2)		 3thw DNA MISMATCH REPAIR
PROTEIN MSH3
(Homo
sapiens) 		3 / 3 ASP B 398
ASN B 376
SER B 403
 None
 1.02A 3lsfB-3thwB:
undetectable
3lsfE-3thwB:
undetectable		 3lsfB-3thwB:
14.68
3lsfE-3thwB:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		 3thw DNA MISMATCH REPAIR
PROTEIN MSH3
(Homo
sapiens) 		4 / 6 TYR B 912
ASN B 582
LEU B 585
ASP B 586
 None
 1.31A 3lslG-3thwB:
undetectable		 3lslG-3thwB:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUN_A_CCSA165_0
(LYSOZYME)		 3thw DNA MISMATCH REPAIR
PROTEIN MSH3
(Homo
sapiens) 		3 / 3 ASN B 749
ALA B 767
LYS B 748
 None
 1.04A 3runA-3thwB:
undetectable		 3runA-3thwB:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3thw DNA MISMATCH REPAIR
PROTEIN MSH3
(Homo
sapiens) 		5 / 12 LEU B 423
GLY B 380
SER B 395
GLN B 397
ILE B 381
 None
 1.43A 4djeA-3thwB:
undetectable		 4djeA-3thwB:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3thw DNA MISMATCH REPAIR
PROTEIN MSH3
(Homo
sapiens) 		5 / 12 LEU B 585
ALA B 587
SER B 589
TYR B 912
ARG B 839
 None
 1.34A 4ejwA-3thwB:
undetectable		 4ejwA-3thwB:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FHB_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3thw DNA MISMATCH REPAIR
PROTEIN MSH3
(Homo
sapiens) 		5 / 12 ILE B 381
THR B 427
ILE B 431
LEU B 417
ILE B 362
 None
 1.01A 4fhbA-3thwB:
undetectable		 4fhbA-3thwB:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3thw DNA MISMATCH REPAIR
PROTEIN MSH3
(Homo
sapiens) 		5 / 12 ILE B 381
THR B 427
ILE B 431
LEU B 417
ILE B 362
 None
 1.01A 4i13A-3thwB:
undetectable		 4i13A-3thwB:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3thw DNA MISMATCH REPAIR
PROTEIN MSH3
(Homo
sapiens) 		5 / 12 ILE B 381
THR B 427
ILE B 431
LEU B 417
ILE B 362
 None
 1.04A 4kjjA-3thwB:
undetectable		 4kjjA-3thwB:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3thw DNA MISMATCH REPAIR
PROTEIN MSH3
(Homo
sapiens) 		5 / 12 ILE B 381
THR B 427
ILE B 431
LEU B 417
ILE B 362
 None
 1.06A 4kjkA-3thwB:
undetectable		 4kjkA-3thwB:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3thw DNA MISMATCH REPAIR
PROTEIN MSH3
(Homo
sapiens) 		4 / 8 LEU B 486
SER B 520
VAL B 384
GLY B 383
 None
 0.95A 4klrB-3thwB:
undetectable		 4klrB-3thwB:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3thw DNA MISMATCH REPAIR
PROTEIN MSH3
(Homo
sapiens) 		5 / 12 ILE B 381
THR B 427
ILE B 431
LEU B 417
ILE B 362
 None
 1.04A 4p3rA-3thwB:
undetectable		 4p3rA-3thwB:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3thw DNA MISMATCH REPAIR
PROTEIN MSH3
(Homo
sapiens) 		5 / 12 ILE B 381
THR B 427
ILE B 431
LEU B 417
ILE B 362
 None
 1.03A 4pthA-3thwB:
undetectable		 4pthA-3thwB:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RS0_A_IBPA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3thw DNA MISMATCH REPAIR
PROTEIN MSH3
(Homo
sapiens) 		5 / 9 VAL B 238
LEU B 239
LEU B 288
GLY B 251
ALA B 254
 None
 1.07A 4rs0A-3thwB:
3.2		 4rs0A-3thwB:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)		 3thw DNA MISMATCH REPAIR
PROTEIN MSH3
(Homo
sapiens) 		5 / 12 MET B 883
ILE B 885
VAL B 900
GLY B 892
THR B 873
 None
 1.02A 5byjA-3thwB:
undetectable		 5byjA-3thwB:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D75_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 3thw DNA MISMATCH REPAIR
PROTEIN MSH3
(Homo
sapiens) 		5 / 11 LEU B 585
VAL B 842
ILE B 920
ALA B 915
ILE B 850
 None
 1.20A 5d75A-3thwB:
undetectable		 5d75A-3thwB:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H1E_A_VDXA501_1
(VITAMIN D3 RECEPTOR)		 3thw DNA MISMATCH REPAIR
PROTEIN MSH3
(Homo
sapiens) 		5 / 12 LEU B 567
ILE B 909
ARG B 584
SER B 911
VAL B 554
 None
 1.43A 5h1eA-3thwB:
undetectable		 5h1eA-3thwB:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3thw DNA MISMATCH REPAIR
PROTEIN MSH3
(Homo
sapiens) 		4 / 5 GLU B 302
THR B 301
GLU B 242
LEU B 223
 None
 0.90A 5hm8A-3thwB:
undetectable		 5hm8A-3thwB:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_B_ADNB501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3thw DNA MISMATCH REPAIR
PROTEIN MSH3
(Homo
sapiens) 		4 / 5 GLU B 302
THR B 301
GLU B 242
LEU B 223
 None
 0.90A 5hm8B-3thwB:
undetectable		 5hm8B-3thwB:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_C_ADNC501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3thw DNA MISMATCH REPAIR
PROTEIN MSH3
(Homo
sapiens) 		4 / 5 GLU B 302
THR B 301
GLU B 242
LEU B 223
 None
 0.90A 5hm8C-3thwB:
undetectable		 5hm8C-3thwB:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3thw DNA MISMATCH REPAIR
PROTEIN MSH3
(Homo
sapiens) 		4 / 5 GLU B 302
THR B 301
GLU B 242
LEU B 223
 None
 0.90A 5hm8D-3thwB:
undetectable		 5hm8D-3thwB:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3thw DNA MISMATCH REPAIR
PROTEIN MSH3
(Homo
sapiens) 		4 / 5 GLU B 302
THR B 301
GLU B 242
LEU B 223
 None
 0.90A 5hm8E-3thwB:
undetectable		 5hm8E-3thwB:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3thw DNA MISMATCH REPAIR
PROTEIN MSH3
(Homo
sapiens) 		4 / 5 GLU B 302
THR B 301
GLU B 242
LEU B 223
 None
 0.90A 5hm8F-3thwB:
undetectable		 5hm8F-3thwB:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_G_ADNG501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3thw DNA MISMATCH REPAIR
PROTEIN MSH3
(Homo
sapiens) 		4 / 5 GLU B 302
THR B 301
GLU B 242
LEU B 223
 None
 1.04A 5hm8G-3thwB:
2.2		 5hm8G-3thwB:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_2
(ADENOSYLHOMOCYSTEINA
SE)		 3thw DNA MISMATCH REPAIR
PROTEIN MSH3
(Homo
sapiens) 		4 / 5 GLU B 302
THR B 301
GLU B 242
LEU B 223
 None
 0.90A 5hm8H-3thwB:
undetectable		 5hm8H-3thwB:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3thw DNA MISMATCH REPAIR
PROTEIN MSH3
(Homo
sapiens) 		5 / 12 ILE B 666
HIS B 818
ALA B 820
SER B 656
ILE B 654
 None
 1.10A 5igvA-3thwB:
undetectable		 5igvA-3thwB:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3thw DNA MISMATCH REPAIR
PROTEIN MSH3
(Homo
sapiens) 		5 / 12 ILE B 666
HIS B 818
ALA B 820
SER B 656
ILE B 654
 None
 1.13A 5iwuA-3thwB:
undetectable		 5iwuA-3thwB:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 3thw DNA MISMATCH REPAIR
PROTEIN MSH3
(Homo
sapiens) 		3 / 3 THR B 572
SER B 411
ASP B 394
 None
 0.84A 5kvaB-3thwB:
undetectable		 5kvaB-3thwB:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 3thw DNA MISMATCH REPAIR
PROTEIN MSH3
(Homo
sapiens) 		4 / 6 GLN B 899
VAL B 857
LEU B 997
MET B 526
 None
 1.23A 6brdB-3thwB:
undetectable		 6brdB-3thwB:
6.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9H_R_ADNR400_1
(CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1)		 3thw DNA MISMATCH REPAIR
PROTEIN MSH3
(Homo
sapiens) 		5 / 10 VAL B 822
PHE B 643
GLU B 642
LEU B 609
THR B 560
 None
 1.31A 6d9hR-3thwB:
3.0		 6d9hR-3thwB:
6.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 3thw DNA MISMATCH REPAIR
PROTEIN MSH3
(Homo
sapiens) 		4 / 5 TYR B 735
GLN B 734
GLY B 712
ILE B 717
 None
 1.40A 6debB-3thwB:
undetectable		 6debB-3thwB:
7.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM0_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3thw DNA MISMATCH REPAIR
PROTEIN MSH3
(Homo
sapiens) 		5 / 10 SER B 561
LEU B 636
LEU B 819
ILE B 632
GLY B 615
 None
 1.16A 6dm0B-3thwB:
4.0
6dm0C-3thwB:
2.5		 6dm0B-3thwB:
6.13
6dm0C-3thwB:
6.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 3thw DNA MISMATCH REPAIR
PROTEIN MSH3
(Homo
sapiens) 		3 / 3 ARG B 443
LYS B 291
TYR B 293
 None
 1.31A 6gnaA-3thwB:
undetectable		 6gnaA-3thwB:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 3thw DNA MISMATCH REPAIR
PROTEIN MSH3
(Homo
sapiens) 		3 / 3 ARG B 443
LYS B 291
TYR B 293
 None
 1.31A 6gnbA-3thwB:
undetectable		 6gnbA-3thwB:
16.80