SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3thz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC8_0
(ACTINOMYCIN D)		 3thz DNA MISMATCH REPAIR
PROTEIN MSH2
(Homo
sapiens) 		3 / 3 THR A  33
THR A  31
PRO A  30
 None
 0.84A 1dscC-3thzA:
undetectable		 1dscC-3thzA:
1.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 3thz DNA MISMATCH REPAIR
PROTEIN MSH2
(Homo
sapiens) 		4 / 4 THR A 905
LEU A 908
VAL A 891
LEU A 888
 None
 0.95A 1mz9D-3thzA:
undetectable		 1mz9D-3thzA:
4.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_D_FUAD705_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3thz DNA MISMATCH REPAIR
PROTEIN MSH2
(Homo
sapiens) 		5 / 12 PHE A  85
SER A  87
LEU A  92
VAL A  34
ALA A  45
 None
 1.49A 1q23D-3thzA:
undetectable
1q23E-3thzA:
undetectable		 1q23D-3thzA:
12.71
1q23E-3thzA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 3thz DNA MISMATCH REPAIR
PROTEIN MSH2
(Homo
sapiens) 		3 / 3 ASP A 386
LYS A 393
ARG A 396
 None
 1.04A 1ra8A-3thzA:
undetectable		 1ra8A-3thzA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3thz DNA MISMATCH REPAIR
PROTEIN MSH2
(Homo
sapiens) 		5 / 9 LEU A 372
LEU A 432
VAL A 605
ALA A 604
LEU A 381
 None
 1.10A 1tbfA-3thzA:
undetectable		 1tbfA-3thzA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U72_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 3thz DNA MISMATCH REPAIR
PROTEIN MSH2
(Homo
sapiens) 		5 / 12 LEU A 432
PHE A 366
GLN A 377
LEU A 381
VAL A 417
 None
 1.18A 1u72A-3thzA:
undetectable		 1u72A-3thzA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_1
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 3thz DNA MISMATCH REPAIR
PROTEIN MSH2
(Homo
sapiens) 		3 / 3 GLY A 338
ASP A 603
ASN A 343
 None
 0.66A 1vq1A-3thzA:
2.9		 1vq1A-3thzA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 3thz DNA MISMATCH REPAIR
PROTEIN MSH2
(Homo
sapiens) 		4 / 5 ALA A 573
ILE A 577
ASN A 477
ASP A 475
 None
 1.05A 2h4jA-3thzA:
undetectable		 2h4jA-3thzA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_C_ASDC1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 3thz DNA MISMATCH REPAIR
PROTEIN MSH2
(Homo
sapiens) 		4 / 8 ILE A 685
GLY A 683
LEU A 310
LEU A 312
 None
 0.94A 2vctC-3thzA:
undetectable		 2vctC-3thzA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)		 3thz DNA MISMATCH REPAIR
PROTEIN MSH2
(Homo
sapiens) 		4 / 6 THR A 456
GLU A 452
PHE A 450
ILE A 584
 None
 1.27A 2w98B-3thzA:
undetectable		 2w98B-3thzA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 3thz DNA MISMATCH REPAIR
PROTEIN MSH2
(Homo
sapiens) 		4 / 8 SER A 284
ARG A 171
TYR A 121
SER A 129
 None
 1.10A 2zw9B-3thzA:
undetectable		 2zw9B-3thzA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_B_SAMB270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 3thz DNA MISMATCH REPAIR
PROTEIN MSH2
(Homo
sapiens) 		5 / 11 LEU A 277
ALA A 272
ILE A 274
SER A 269
LEU A 270
 None
 1.23A 3gyqB-3thzA:
undetectable		 3gyqB-3thzA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEC_A_65BA561_0
(P66 REVERSE
TRANSCRIPTASE)		 3thz DNA MISMATCH REPAIR
PROTEIN MSH2
(Homo
sapiens) 		5 / 12 LEU A 190
VAL A 150
TYR A 165
GLY A 162
PRO A 179
 None
 1.17A 3mecA-3thzA:
2.3		 3mecA-3thzA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3thz DNA MISMATCH REPAIR
PROTEIN MSH2
(Homo
sapiens) 		4 / 8 ARG A 308
LEU A 302
ALA A 710
ALA A 305
 None
 0.85A 3ns1L-3thzA:
undetectable		 3ns1L-3thzA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_B_CP6B609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3thz DNA MISMATCH REPAIR
PROTEIN MSH2
(Homo
sapiens) 		5 / 10 ILE A 746
ALA A 305
ASP A 303
ILE A 766
ILE A 747
 None
 1.23A 3qgtB-3thzA:
undetectable		 3qgtB-3thzA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3thz DNA MISMATCH REPAIR
PROTEIN MSH2
(Homo
sapiens) 		4 / 8 ILE A 194
LEU A 191
VAL A 161
GLY A 162
 None
 0.90A 3w1wA-3thzA:
undetectable		 3w1wA-3thzA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3thz DNA MISMATCH REPAIR
PROTEIN MSH2
(Homo
sapiens) 		4 / 8 ILE A 217
LEU A 213
VAL A 161
GLY A 162
 None
 0.85A 3w1wA-3thzA:
undetectable		 3w1wA-3thzA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)		 3thz DNA MISMATCH REPAIR
PROTEIN MSH2
(Homo
sapiens) 		4 / 8 PHE A  42
VAL A  79
LEU A  11
HIS A  46
 None
 1.21A 4f5zA-3thzA:
undetectable		 4f5zA-3thzA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI507_0
(RNA POLYMERASE
3D-POL)		 3thz DNA MISMATCH REPAIR
PROTEIN MSH2
(Homo
sapiens) 		3 / 3 LYS A 471
PRO A 472
SER A 473
 None
 0.37A 4k50I-3thzA:
undetectable		 4k50I-3thzA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MS4_A_2C0A501_1
(GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1)		 3thz DNA MISMATCH REPAIR
PROTEIN MSH2
(Homo
sapiens) 		4 / 8 SER A 738
SER A 734
ILE A 216
GLU A 731
 None
 1.25A 4ms4A-3thzA:
undetectable		 4ms4A-3thzA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3thz DNA MISMATCH REPAIR
PROTEIN MSH2
(Homo
sapiens) 		4 / 5 ILE A 632
VAL A 702
PHE A 694
HIS A 665
 None
 1.35A 4rzvA-3thzA:
undetectable		 4rzvA-3thzA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_H_CHDH103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3thz DNA MISMATCH REPAIR
PROTEIN MSH2
(Homo
sapiens) 		5 / 11 LEU A 244
LEU A 173
GLU A 278
LEU A 279
ALA A 272
 None
 1.21A 4wg0H-3thzA:
undetectable
4wg0I-3thzA:
undetectable
4wg0J-3thzA:
undetectable		 4wg0H-3thzA:
1.82
4wg0I-3thzA:
1.82
4wg0J-3thzA:
1.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_H_CHDH103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3thz DNA MISMATCH REPAIR
PROTEIN MSH2
(Homo
sapiens) 		5 / 11 LEU A 372
ARG A 373
LEU A 376
LEU A 421
LEU A 602
 None
 1.12A 4wg0H-3thzA:
undetectable
4wg0I-3thzA:
undetectable
4wg0J-3thzA:
undetectable		 4wg0H-3thzA:
1.82
4wg0I-3thzA:
1.82
4wg0J-3thzA:
1.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3thz DNA MISMATCH REPAIR
PROTEIN MSH2
(Homo
sapiens) 		5 / 11 LEU A 602
LEU A 421
LEU A 372
ARG A 373
LEU A 376
 None
 1.07A 4wg0G-3thzA:
undetectable
4wg0H-3thzA:
undetectable
4wg0I-3thzA:
undetectable		 4wg0G-3thzA:
1.82
4wg0H-3thzA:
1.82
4wg0I-3thzA:
1.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_J_CHDJ103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3thz DNA MISMATCH REPAIR
PROTEIN MSH2
(Homo
sapiens) 		5 / 11 LEU A 372
ARG A 373
LEU A 376
LEU A 421
LEU A 602
 None
 1.01A 4wg0J-3thzA:
undetectable
4wg0K-3thzA:
undetectable
4wg0L-3thzA:
undetectable		 4wg0J-3thzA:
1.82
4wg0K-3thzA:
1.82
4wg0L-3thzA:
1.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H4D_A_BBIA403_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 3thz DNA MISMATCH REPAIR
PROTEIN MSH2
(Homo
sapiens) 		4 / 6 ARG A  55
GLU A  56
PHE A  88
VAL A  78
 None
 1.41A 5h4dA-3thzA:
undetectable		 5h4dA-3thzA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_C_FK5C201_1
(FK506-BINDING
PROTEIN 1)		 3thz DNA MISMATCH REPAIR
PROTEIN MSH2
(Homo
sapiens) 		5 / 10 TYR A 299
ARG A 355
ILE A 194
TYR A 165
LEU A 190
 None
 1.34A 5hw8C-3thzA:
undetectable
5hw8H-3thzA:
undetectable		 5hw8C-3thzA:
8.32
5hw8H-3thzA:
8.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 3thz DNA MISMATCH REPAIR
PROTEIN MSH2
(Homo
sapiens) 		3 / 3 VAL A 582
GLN A 402
CYH A 404
 None
 0.75A 5icxA-3thzA:
undetectable
5icxE-3thzA:
undetectable		 5icxA-3thzA:
13.48
5icxE-3thzA:
1.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 3thz DNA MISMATCH REPAIR
PROTEIN MSH2
(Homo
sapiens) 		4 / 6 GLU A 749
ALA A 309
LEU A 310
TYR A 678
 None
 0.98A 5igiA-3thzA:
2.8		 5igiA-3thzA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3thz DNA MISMATCH REPAIR
PROTEIN MSH2
(Homo
sapiens) 		4 / 8 ASP A  49
ARG A  35
GLU A 101
GLU A  28
 None
 1.22A 6mn4C-3thzA:
undetectable		 6mn4C-3thzA:
15.49