SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ti7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_2
(NEURAMINIDASE)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		3 / 3 ASP A  79
ARG A 136
ILE A  61
 None
 0.74A 1a4gB-3ti7A:
undetectable		 1a4gB-3ti7A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_A_MTXA732_1
(THYMIDYLATE SYNTHASE)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		5 / 12 ILE A 258
LEU A 255
TYR A  14
VAL A 123
ALA A 124
 None
None
None
CA  A 353 (-4.8A)
None
 1.16A 1axwA-3ti7A:
undetectable		 1axwA-3ti7A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_A_CAMA503_0
(CYTOCHROME P450-CAM)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		5 / 9 THR A 229
LEU A 325
VAL A 245
GLY A 326
VAL A 283
 None
 1.42A 1dz8A-3ti7A:
undetectable		 1dz8A-3ti7A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_B_CAMB502_0
(CYTOCHROME P450-CAM)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		5 / 9 THR A 229
LEU A 325
VAL A 245
GLY A 326
VAL A 283
 None
 1.42A 1dz8B-3ti7A:
undetectable		 1dz8B-3ti7A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_B_CAMB502_0
(CYTOCHROME P450-CAM)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		5 / 9 THR A 229
LEU A 325
VAL A 245
GLY A 326
VAL A 283
 None
 1.45A 1dz9B-3ti7A:
undetectable		 1dz9B-3ti7A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_A_DVAA6_0
(GRAMICIDIN B)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		3 / 3 ALA A 115
VAL A 126
TRP A  26
 None
 0.83A 1jo3A-3ti7A:
undetectable		 1jo3A-3ti7A:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_B_DVAB6_0
(GRAMICIDIN B)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		3 / 3 ALA A 115
VAL A 126
TRP A  26
 None
 0.83A 1jo3B-3ti7A:
undetectable		 1jo3B-3ti7A:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		4 / 8 ASN A  53
GLY A 111
THR A 257
GLY A 122
 None
None
None
CA  A 353 ( 4.3A)
 0.70A 1jr1B-3ti7A:
undetectable		 1jr1B-3ti7A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA734_1
(ALPHA AMYLASE)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		4 / 6 ASN A  23
TRP A  26
TYR A  14
GLY A  16
 None
 1.31A 1mxdA-3ti7A:
1.8		 1mxdA-3ti7A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA734_1
(ALPHA AMYLASE)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		4 / 6 TRP A  26
HIS A 282
TYR A  14
GLY A  19
 None
 1.38A 1mxdA-3ti7A:
1.8		 1mxdA-3ti7A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		4 / 7 ASN A  23
TRP A  26
TYR A  14
GLY A  16
 None
 1.33A 1mxgA-3ti7A:
undetectable		 1mxgA-3ti7A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_1
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		4 / 5 ASP A 259
VAL A 260
SER A 269
ASP A  46
 None
 1.22A 1n2xB-3ti7A:
2.6		 1n2xB-3ti7A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_A_DVAA6_0
(GRAMICIDIN A)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		3 / 3 ALA A 115
VAL A 126
TRP A  26
 None
 0.93A 1ng8A-3ti7A:
undetectable		 1ng8A-3ti7A:
3.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NG8_B_DVAB6_0
(GRAMICIDIN A)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		3 / 3 ALA A 115
VAL A 126
TRP A  26
 None
 0.93A 1ng8B-3ti7A:
undetectable		 1ng8B-3ti7A:
3.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_A_DVAA6_0
(GRAMICIDIN A)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		3 / 3 ALA A 115
VAL A 126
TRP A  26
 None
 0.94A 1nrmA-3ti7A:
undetectable		 1nrmA-3ti7A:
5.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NRM_B_DVAB6_0
(GRAMICIDIN A)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		3 / 3 ALA A 115
VAL A 126
TRP A  26
 None
 0.94A 1nrmB-3ti7A:
undetectable		 1nrmB-3ti7A:
5.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_A_DVAA6_0
(GRAMICIDIN C)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		3 / 3 ALA A 115
VAL A 126
TRP A  26
 None
 0.77A 1nt6A-3ti7A:
undetectable		 1nt6A-3ti7A:
5.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT6_B_DVAB6_0
(GRAMICIDIN C)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		3 / 3 ALA A 115
VAL A 126
TRP A  26
 None
 0.77A 1nt6B-3ti7A:
undetectable		 1nt6B-3ti7A:
5.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		5 / 12 ILE A 258
LEU A 255
TYR A  14
VAL A 123
ALA A 124
 None
None
None
CA  A 353 (-4.8A)
None
 1.07A 1tlsA-3ti7A:
undetectable		 1tlsA-3ti7A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		5 / 12 ILE A 258
LEU A 255
TYR A  14
VAL A 123
ALA A 124
 None
None
None
CA  A 353 (-4.8A)
None
 1.05A 1tlsB-3ti7A:
undetectable		 1tlsB-3ti7A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		5 / 12 ILE A 258
LEU A 255
TYR A  14
VAL A 123
ALA A 124
 None
None
None
CA  A 353 (-4.8A)
None
 1.13A 1tsnA-3ti7A:
undetectable		 1tsnA-3ti7A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		5 / 12 ILE A  44
LEU A  50
GLY A  52
ALA A 110
VAL A 109
 None
 0.94A 2oc8A-3ti7A:
undetectable		 2oc8A-3ti7A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_A_VD3A2001_1
(VITAMIN D
HYDROXYLASE)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		5 / 12 ILE A 309
ASN A 174
LEU A 301
ILE A 291
ALA A 294
 None
 1.06A 3a50A-3ti7A:
undetectable		 3a50A-3ti7A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1200_1
(SERUM ALBUMIN)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		4 / 5 ILE A 254
HIS A 108
TYR A  14
GLY A 111
 None
 1.29A 3b9mA-3ti7A:
undetectable		 3b9mA-3ti7A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_A_TMQA611_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		5 / 10 VAL A 109
ALA A 280
ILE A 203
ILE A 148
LEU A 138
 None
 1.08A 3hbbA-3ti7A:
undetectable		 3hbbA-3ti7A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		5 / 11 VAL A 109
ALA A 280
ILE A 203
ILE A 148
LEU A 138
 None
 1.04A 3hbbC-3ti7A:
undetectable		 3hbbC-3ti7A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		5 / 12 GLY A 324
VAL A 283
GLY A 328
ALA A 228
ALA A 279
 None
 1.10A 3keeB-3ti7A:
undetectable		 3keeB-3ti7A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		5 / 12 GLY A 122
GLY A 125
GLN A  11
ALA A 115
ASN A  53
 CA  A 353 ( 4.3A)
None
None
None
None
 0.97A 3kkzB-3ti7A:
undetectable		 3kkzB-3ti7A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_A_EAAA222_1
(GLUTATHIONE
S-TRANSFERASE P)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		5 / 10 TYR A  14
VAL A 126
GLY A 125
VAL A 330
GLY A 285
 None
 1.00A 3km6A-3ti7A:
undetectable		 3km6A-3ti7A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		5 / 9 TYR A  14
VAL A 126
GLY A 125
VAL A 330
GLY A 285
 None
 1.00A 3kmoA-3ti7A:
undetectable		 3kmoA-3ti7A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_B_EAAB213_1
(GLUTATHIONE
S-TRANSFERASE P)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		4 / 7 TYR A  14
VAL A 126
VAL A 330
GLY A 285
 None
 0.99A 3kmoB-3ti7A:
undetectable		 3kmoB-3ti7A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		3 / 3 SER A 219
SER A 213
HIS A 246
 None
 0.81A 3mzeA-3ti7A:
undetectable		 3mzeA-3ti7A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		5 / 12 LEU A 325
ALA A 249
GLY A 251
GLY A 227
LEU A 247
 None
 1.19A 3ou7A-3ti7A:
undetectable		 3ou7A-3ti7A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		5 / 12 LEU A 325
ALA A 249
GLY A 251
GLY A 227
LEU A 247
 None
 1.21A 3ou7D-3ti7A:
undetectable		 3ou7D-3ti7A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_A_SALA601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		4 / 7 LEU A 321
THR A 229
ILE A 329
GLY A 326
 None
 0.78A 4eq4A-3ti7A:
undetectable		 4eq4A-3ti7A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		4 / 8 LEU A 321
THR A 229
ILE A 329
GLY A 326
 None
 0.83A 4eq4B-3ti7A:
undetectable		 4eq4B-3ti7A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		4 / 7 LEU A 321
THR A 229
ILE A 329
GLY A 326
 None
 0.81A 4eqlA-3ti7A:
undetectable		 4eqlA-3ti7A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_B_SALB602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		4 / 7 LEU A 321
THR A 229
ILE A 329
GLY A 326
 None
 0.80A 4eqlB-3ti7A:
undetectable		 4eqlB-3ti7A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		4 / 8 ASN A  53
GLY A 111
THR A 257
GLY A 122
 None
None
None
CA  A 353 ( 4.3A)
 0.64A 4fo4B-3ti7A:
undetectable		 4fo4B-3ti7A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		5 / 12 ILE A 258
LEU A 255
TYR A  14
VAL A 123
ALA A 124
 None
None
None
CA  A 353 (-4.8A)
None
 1.10A 4foxD-3ti7A:
undetectable		 4foxD-3ti7A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		5 / 12 ILE A 258
LEU A 255
TYR A  14
VAL A 123
ALA A 124
 None
None
None
CA  A 353 (-4.8A)
None
 1.17A 4fqsA-3ti7A:
undetectable		 4fqsA-3ti7A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		5 / 12 ILE A 258
LEU A 255
TYR A  14
VAL A 123
ALA A 124
 None
None
None
CA  A 353 (-4.8A)
None
 1.15A 4fqsB-3ti7A:
undetectable		 4fqsB-3ti7A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8C_A_ADNA401_2
(SUGAR KINASE)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		3 / 3 SER A   7
TYR A 270
PRO A   3
 None
 0.95A 4k8cA-3ti7A:
4.6		 4k8cA-3ti7A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		3 / 3 SER A   7
TYR A 270
PRO A   3
 None
 0.96A 4kahA-3ti7A:
4.5		 4kahA-3ti7A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAH_B_ADNB502_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		3 / 3 SER A   7
TYR A 270
PRO A   3
 None
 0.97A 4kahB-3ti7A:
4.7		 4kahB-3ti7A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		3 / 3 SER A   7
TYR A 270
PRO A   3
 None
 0.95A 4kanA-3ti7A:
4.5		 4kanA-3ti7A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAN_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		3 / 3 SER A   7
TYR A 270
PRO A   3
 None
 0.94A 4kanB-3ti7A:
4.5		 4kanB-3ti7A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KBE_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		3 / 3 SER A   7
TYR A 270
PRO A   3
 None
 0.95A 4kbeA-3ti7A:
4.5		 4kbeA-3ti7A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		4 / 7 LEU A 321
THR A 229
ILE A 329
GLY A 326
 None
 0.89A 4l39B-3ti7A:
undetectable		 4l39B-3ti7A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		3 / 3 SER A   7
TYR A 270
PRO A   3
 None
 0.93A 4lbgA-3ti7A:
4.7		 4lbgA-3ti7A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB401_2
(PROBABLE SUGAR
KINASE PROTEIN)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		3 / 3 SER A   7
TYR A 270
PRO A   3
 None
 0.95A 4lbgB-3ti7A:
4.5		 4lbgB-3ti7A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_3
(PROTEASE)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		3 / 3 ASP A  74
ASP A  69
ASN A  66
 CA  A 354 ( 2.4A)
CA  A 355 ( 2.3A)
None
 0.83A 4q5mA-3ti7A:
undetectable		 4q5mA-3ti7A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		5 / 9 ALA A 204
ALA A 280
GLY A 179
GLY A 178
ASP A  41
 None
 1.19A 4qwuK-3ti7A:
undetectable
4qwuL-3ti7A:
undetectable		 4qwuK-3ti7A:
20.76
4qwuL-3ti7A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		4 / 5 ILE A 113
VAL A  37
PHE A  60
HIS A 282
 None
 1.20A 4rzvA-3ti7A:
undetectable		 4rzvA-3ti7A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		4 / 6 ASP A  49
ALA A 124
THR A 257
TYR A 270
 CA  A 353 (-2.3A)
None
None
None
 1.34A 4w5qA-3ti7A:
undetectable		 4w5qA-3ti7A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		4 / 6 ASP A  49
ALA A 124
THR A 257
TYR A 270
 CA  A 353 (-2.3A)
None
None
None
 1.32A 4w5rA-3ti7A:
undetectable		 4w5rA-3ti7A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		4 / 6 ASP A  49
ALA A 124
THR A 257
TYR A 270
 CA  A 353 (-2.3A)
None
None
None
 1.36A 4w5tA-3ti7A:
undetectable		 4w5tA-3ti7A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		4 / 6 ASP A  49
ALA A 124
THR A 257
TYR A 270
 CA  A 353 (-2.3A)
None
None
None
 1.35A 4z4cA-3ti7A:
undetectable		 4z4cA-3ti7A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		4 / 6 ASP A  49
ALA A 124
THR A 257
TYR A 270
 CA  A 353 (-2.3A)
None
None
None
 1.33A 4z4fA-3ti7A:
undetectable		 4z4fA-3ti7A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		4 / 5 ASP A  49
ALA A 124
THR A 257
TYR A 270
 CA  A 353 (-2.3A)
None
None
None
 1.34A 4z4gA-3ti7A:
undetectable		 4z4gA-3ti7A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		4 / 6 ASP A  49
ALA A 124
THR A 257
TYR A 270
 CA  A 353 (-2.3A)
None
None
None
 1.38A 4z4iA-3ti7A:
2.3		 4z4iA-3ti7A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		5 / 12 VAL A  37
ALA A 204
VAL A 109
GLY A 111
ALA A 110
 None
 1.09A 5kirA-3ti7A:
undetectable		 5kirA-3ti7A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_A_08JA602_1
(CYTOCHROME P450 3A4)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		4 / 7 LEU A 247
ALA A 249
THR A 229
LEU A 325
 None
 1.02A 5te8A-3ti7A:
undetectable		 5te8A-3ti7A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V3C_A_AMHA402_1
(QUEUINE
TRNA-RIBOSYLTRANSFER
ASE)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		5 / 9 ASP A  82
GLY A  43
GLY A 106
ALA A 110
VAL A 109
 None
 1.43A 5v3cA-3ti7A:
undetectable		 5v3cA-3ti7A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		5 / 11 ILE A 203
ALA A 279
LEU A 247
SER A 239
ALA A 212
 None
 1.22A 6ieyA-3ti7A:
3.6
6ieyB-3ti7A:
3.5		 6ieyA-3ti7A:
23.62
6ieyB-3ti7A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV
(Dichelobacter
nodosus) 		5 / 12 PRO A 134
GLY A 151
ASP A 165
GLY A 157
ALA A 170
 None
 1.07A 6nj9K-3ti7A:
undetectable		 6nj9K-3ti7A:
19.00