SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tih'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDW_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 3tih HIV-1 CLADE C
ZM109F.PB4 GP120
(Human
immunodeficiency
virus
1) 		5 / 10 VAL A  65
LEU A 111
PRO A 212
VAL A 255
PHE A 210
 None
 0.97A 1fdwA-3tihA:
undetectable		 1fdwA-3tihA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3tih HIV-1 CLADE C
ZM109F.PB4 GP120
(Human
immunodeficiency
virus
1) 		5 / 12 ILE A 215
ALA A  55
LEU A  52
LEU A 483
ILE A 251
 None
 1.09A 1ra3A-3tihA:
undetectable		 1ra3A-3tihA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 3tih HIV-1 CLADE C
ZM109F.PB4 GP120
(Human
immunodeficiency
virus
1) 		5 / 12 ILE A 215
ALA A  55
LEU A  52
LEU A 483
ILE A 251
 None
 1.07A 2drcB-3tihA:
undetectable		 2drcB-3tihA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1010_1
(SERUM ALBUMIN)		 3tih HIV-1 CLADE C
ZM109F.PB4 GP120
(Human
immunodeficiency
virus
1) 		4 / 8 LEU A 483
ILE A 251
HIS A 249
GLY A 263
 None
 0.66A 3b9lA-3tihA:
undetectable		 3b9lA-3tihA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_1
(UNCHARACTERIZED
PROTEIN)		 3tih HIV-1 CLADE C
ZM109F.PB4 GP120
(Human
immunodeficiency
virus
1) 		3 / 3 THR A 232
LYS A 357
GLU A 269
 None
 0.82A 3ijdB-3tihA:
undetectable		 3ijdB-3tihA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 3tih HIV-1 CLADE C
ZM109F.PB4 GP120
(Human
immunodeficiency
virus
1) 		5 / 12 ASN A 262
SER A 447
PRO A 212
GLY A 380
ILE A 443
 None
 1.47A 3jb2A-3tihA:
undetectable		 3jb2A-3tihA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U88_A_CHDA611_0
(MENIN)		 3tih HIV-1 CLADE C
ZM109F.PB4 GP120
(Human
immunodeficiency
virus
1) 		3 / 3 SER A 375
PHE A 382
LYS A 421
 None
 0.89A 3u88A-3tihA:
undetectable		 3u88A-3tihA:
20.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)		 3tih HIV-1 CLADE C
ZM109F.PB4 GP120
(Human
immunodeficiency
virus
1) 		4 / 6 ASP A  57
PRO A 214
HIS A 216
ARG A 252
 None
 0.47A 4lajA-3tihA:
45.0
4lajB-3tihA:
44.9		 4lajA-3tihA:
77.05
4lajB-3tihA:
77.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 3tih HIV-1 CLADE C
ZM109F.PB4 GP120
(Human
immunodeficiency
virus
1) 		5 / 11 ILE A 215
ALA A  55
LEU A  52
LEU A 483
ILE A 251
 None
 1.05A 4p66A-3tihA:
undetectable		 4p66A-3tihA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 3tih HIV-1 CLADE C
ZM109F.PB4 GP120
(Human
immunodeficiency
virus
1) 		4 / 8 GLY A 237
TYR A 484
SER A 234
PHE A 233
 None
 0.93A 4wryA-3tihA:
undetectable		 4wryA-3tihA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 3tih HIV-1 CLADE C
ZM109F.PB4 GP120
(Human
immunodeficiency
virus
1) 		4 / 8 GLY A 237
TYR A 484
SER A 234
PHE A 233
 None
 0.89A 4wrzA-3tihA:
undetectable		 4wrzA-3tihA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS0_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 3tih HIV-1 CLADE C
ZM109F.PB4 GP120
(Human
immunodeficiency
virus
1) 		4 / 7 GLY A 237
TYR A 484
SER A 234
PHE A 233
 None
 0.89A 4ws0A-3tihA:
undetectable		 4ws0A-3tihA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WS1_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 3tih HIV-1 CLADE C
ZM109F.PB4 GP120
(Human
immunodeficiency
virus
1) 		4 / 8 GLY A 237
TYR A 484
SER A 234
PHE A 233
 None
 0.88A 4ws1A-3tihA:
undetectable		 4ws1A-3tihA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZ8_A_GCSA208_1
(GLUCANASE/CHITOSANAS
E)		 3tih HIV-1 CLADE C
ZM109F.PB4 GP120
(Human
immunodeficiency
virus
1) 		4 / 7 GLU A  62
TYR A  61
ASP A  57
ALA A  58
 None
 1.04A 4zz8A-3tihA:
undetectable		 4zz8A-3tihA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_A_DAHA60_1
(PUTATIVE CYTOCHROME
C)		 3tih HIV-1 CLADE C
ZM109F.PB4 GP120
(Human
immunodeficiency
virus
1) 		4 / 6 HIS A 374
ASN A 377
VAL A 255
LEU A 260
 None
 1.32A 5xdhA-3tihA:
undetectable
5xdhC-3tihA:
undetectable		 5xdhA-3tihA:
11.01
5xdhC-3tihA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_B_DAHB60_1
(PUTATIVE CYTOCHROME
C)		 3tih HIV-1 CLADE C
ZM109F.PB4 GP120
(Human
immunodeficiency
virus
1) 		4 / 5 HIS A 374
ASN A 377
VAL A 255
LEU A 260
 None
 1.40A 5xdhB-3tihA:
undetectable		 5xdhB-3tihA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_C_DAHC60_1
(PUTATIVE CYTOCHROME
C)		 3tih HIV-1 CLADE C
ZM109F.PB4 GP120
(Human
immunodeficiency
virus
1) 		4 / 6 HIS A 374
ASN A 377
VAL A 255
LEU A 260
 None
 1.25A 5xdhA-3tihA:
undetectable
5xdhC-3tihA:
undetectable		 5xdhA-3tihA:
11.01
5xdhC-3tihA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3tih HIV-1 CLADE C
ZM109F.PB4 GP120
(Human
immunodeficiency
virus
1) 		3 / 3 SER A 264
HIS A 287
TYR A 484
 None
 0.99A 5y2tA-3tihA:
undetectable		 5y2tA-3tihA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IE8_A_CHDA201_0
(REGULATORY PROTEIN)		 3tih HIV-1 CLADE C
ZM109F.PB4 GP120
(Human
immunodeficiency
virus
1) 		5 / 12 LEU A 349
THR A 283
ILE A 284
LEU A 453
LEU A 288
 None
 1.30A 6ie8A-3tihA:
undetectable		 6ie8A-3tihA:
17.80