SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tis'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T69_A_SHHA379_1
(HISTONE DEACETYLASE
8)		 3tis PROTEIN YRDA
(Escherichia
coli) 		5 / 12 HIS A  70
HIS A  96
GLY A  97
HIS A  67
ASP A  48
 ZN  A 185 (-3.4A)
ZN  A 185 (-3.3A)
None
ZN  A 185 (-3.2A)
None
 1.34A 1t69A-3tisA:
undetectable		 1t69A-3tisA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VIF_A_FOLA1_0
(DIHYDROFOLATE
REDUCTASE)		 3tis PROTEIN YRDA
(Escherichia
coli) 		3 / 3 GLN A 149
ILE A 150
TYR A 142
 None
 0.69A 1vifA-3tisA:
undetectable		 1vifA-3tisA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_1
(VITAMIN D RECEPTOR)		 3tis PROTEIN YRDA
(Escherichia
coli) 		5 / 12 PHE A  12
LEU A   5
VAL A   4
VAL A  19
LEU A 176
 None
 1.39A 2hc4A-3tisA:
undetectable		 2hc4A-3tisA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)		 3tis PROTEIN YRDA
(Escherichia
coli) 		4 / 7 GLY A 160
ASP A  86
TYR A 163
ARG A  57
 None
 1.21A 3arrA-3tisA:
undetectable		 3arrA-3tisA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		 3tis PROTEIN YRDA
(Escherichia
coli) 		4 / 7 GLY A 160
ASP A  86
TYR A 163
ARG A  57
 None
 1.20A 3aruA-3tisA:
undetectable		 3aruA-3tisA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		 3tis PROTEIN YRDA
(Escherichia
coli) 		5 / 12 ALA A 116
VAL A 118
VAL A  43
ILE A  45
MET A  65
 None
 1.10A 3czhA-3tisA:
undetectable		 3czhA-3tisA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		 3tis PROTEIN YRDA
(Escherichia
coli) 		5 / 12 ALA A 116
VAL A 118
VAL A  43
ILE A  45
MET A  65
 None
 1.11A 3czhB-3tisA:
undetectable		 3czhB-3tisA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_2
(PROTEASE)		 3tis PROTEIN YRDA
(Escherichia
coli) 		5 / 12 GLY A  55
ALA A  56
VAL A 169
GLY A  38
ILE A  39
 None
 0.95A 3ucbB-3tisA:
undetectable		 3ucbB-3tisA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_1
(METHYLTRANSFERASE
NSUN4)		 3tis PROTEIN YRDA
(Escherichia
coli) 		3 / 3 ASP A  86
ARG A 162
ASP A  36
 None
 0.89A 4fp9C-3tisA:
undetectable		 4fp9C-3tisA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_1
(METHYLTRANSFERASE
NSUN4)		 3tis PROTEIN YRDA
(Escherichia
coli) 		3 / 3 ASP A  86
ARG A 162
ASP A  36
 None
 0.89A 4fp9F-3tisA:
undetectable		 4fp9F-3tisA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B50_A_OAQA302_0
(SULFOTRANSFERASE
OXAMNIQUINE
RESISTANCE PROTEIN)		 3tis PROTEIN YRDA
(Escherichia
coli) 		5 / 12 MET A  65
LEU A  95
VAL A  31
VAL A  52
ASP A  48
 None
 1.26A 6b50A-3tisA:
undetectable		 6b50A-3tisA:
21.24