SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tj8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_1
(PROTEASE)		 3tj8 UREASE ACCESSORY
PROTEIN UREE
(Helicobacter
pylori) 		5 / 12 LEU A  16
ASP A  12
ILE A  70
ILE A  62
GLY A  60
 None
 0.98A 2o4nA-3tj8A:
undetectable		 2o4nA-3tj8A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		 3tj8 UREASE ACCESSORY
PROTEIN UREE
(Helicobacter
pylori) 		4 / 6 LEU A 126
LEU A 123
ILE A  98
ARG A 101
 None
 0.93A 2rlfA-3tj8A:
undetectable
2rlfB-3tj8A:
undetectable		 2rlfA-3tj8A:
15.06
2rlfB-3tj8A:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOU_A_ACTA228_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 3tj8 UREASE ACCESSORY
PROTEIN UREE
(Helicobacter
pylori) 		4 / 4 ALA A 104
ARG A  31
TYR A 106
ARG A 145
 None
 1.49A 3touA-3tj8A:
0.0		 3touA-3tj8A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOU_B_ACTB228_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 3tj8 UREASE ACCESSORY
PROTEIN UREE
(Helicobacter
pylori) 		4 / 4 ALA A 104
ARG A  31
TYR A 106
ARG A 145
 None
 1.44A 3touB-3tj8A:
0.0		 3touB-3tj8A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 3tj8 UREASE ACCESSORY
PROTEIN UREE
(Helicobacter
pylori) 		3 / 3 TYR A 106
ARG A  31
SER A 142
 None
 1.04A 4khpI-3tj8A:
undetectable
4khpJ-3tj8A:
undetectable		 4khpI-3tj8A:
20.24
4khpJ-3tj8A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		 3tj8 UREASE ACCESSORY
PROTEIN UREE
(Helicobacter
pylori) 		5 / 11 THR A 116
LEU A 146
VAL A  91
ILE A  83
LEU A 126
 None
 1.28A 4lhmA-3tj8A:
undetectable		 4lhmA-3tj8A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_1
(ASPARTYL PROTEASE)		 3tj8 UREASE ACCESSORY
PROTEIN UREE
(Helicobacter
pylori) 		5 / 11 LEU A  16
ASP A  12
ILE A  70
ILE A  62
GLY A  60
 None
 0.93A 4q1xA-3tj8A:
undetectable		 4q1xA-3tj8A:
23.60