SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tji'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3tji MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN
(Enterobacter
sp.
638) 		3 / 3 GLN A 283
ILE A 365
HIS A 322
 None
 0.62A 1fm9A-3tjiA:
undetectable		 1fm9A-3tjiA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3tji MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN
(Enterobacter
sp.
638) 		3 / 3 GLN A 283
ILE A 365
HIS A 322
 None
 0.62A 1k74A-3tjiA:
undetectable		 1k74A-3tjiA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3tji MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN
(Enterobacter
sp.
638) 		5 / 12 ILE A 315
GLY A 364
VAL A 367
ALA A 105
GLY A  34
 None
 1.21A 1kiaB-3tjiA:
undetectable		 1kiaB-3tjiA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 3tji MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN
(Enterobacter
sp.
638) 		5 / 12 HIS A 280
THR A 313
GLY A 316
GLY A 308
VAL A 319
 None
 1.17A 1n2xA-3tjiA:
undetectable		 1n2xA-3tjiA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 3tji MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN
(Enterobacter
sp.
638) 		5 / 12 THR A 398
ASP A 205
LEU A 210
LEU A 242
GLU A 257
 None
MG  A 601 (-2.7A)
None
None
MG  A 601 ( 2.4A)
 1.18A 2zw9B-3tjiA:
undetectable		 2zw9B-3tjiA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_C_ADNC438_2
(ADENOSYLHOMOCYSTEINA
SE)		 3tji MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN
(Enterobacter
sp.
638) 		4 / 5 GLN A 153
THR A 387
HIS A 384
HIS A 207
 None
None
None
GOL  A 400 (-4.0A)
 1.45A 3g1uC-3tjiA:
undetectable		 3g1uC-3tjiA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 3tji MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN
(Enterobacter
sp.
638) 		5 / 11 MET A  74
ILE A   9
VAL A  93
VAL A  24
ILE A  90
 None
 1.12A 3rf4A-3tjiA:
undetectable
3rf4C-3tjiA:
undetectable		 3rf4A-3tjiA:
14.69
3rf4C-3tjiA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB160_0
(HEME-BINDING PROTEIN
HUTZ)		 3tji MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN
(Enterobacter
sp.
638) 		4 / 4 LEU A 258
GLY A 256
LEU A 255
GLU A 231
 None
None
None
MG  A 601 (-2.8A)
 0.98A 3tgvB-3tjiA:
undetectable		 3tgvB-3tjiA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 3tji MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN
(Enterobacter
sp.
638) 		5 / 12 TYR A 110
GLY A 364
GLY A 106
GLY A 348
PRO A 360
 None
 1.15A 4blvA-3tjiA:
undetectable		 4blvA-3tjiA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTR_A_IBPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3tji MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN
(Enterobacter
sp.
638) 		4 / 8 TYR A 157
HIS A 204
LEU A 210
LEU A 218
 None
 0.94A 4jtrA-3tjiA:
4.9		 4jtrA-3tjiA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		 3tji MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN
(Enterobacter
sp.
638) 		4 / 6 SER A  91
GLY A 310
ASP A 311
GLY A 308
 None
None
GOL  A 400 (-2.7A)
None
 0.98A 4koeA-3tjiA:
undetectable
4koeB-3tjiA:
undetectable
4koeC-3tjiA:
undetectable		 4koeA-3tjiA:
19.88
4koeB-3tjiA:
19.88
4koeC-3tjiA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_B_0HKB1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 3tji MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN
(Enterobacter
sp.
638) 		4 / 4 ASN A 324
TRP A 306
LEU A 293
PHE A 276
 None
 1.45A 4u15B-3tjiA:
0.0		 4u15B-3tjiA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 3tji MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN
(Enterobacter
sp.
638) 		4 / 6 GLY A 310
ASP A 311
GLY A 308
SER A  91
 None
GOL  A 400 (-2.7A)
None
None
 0.98A 4z53A-3tjiA:
undetectable
4z53B-3tjiA:
undetectable		 4z53A-3tjiA:
19.04
4z53B-3tjiA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 3tji MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN
(Enterobacter
sp.
638) 		5 / 12 ASN A  75
ASP A  94
LEU A 323
PHE A 113
ILE A 287
 None
 1.38A 5dv4A-3tjiA:
undetectable		 5dv4A-3tjiA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 3tji MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN
(Enterobacter
sp.
638) 		3 / 3 ARG A  15
HIS A  19
ARG A 382
 None
 0.88A 5iaoC-3tjiA:
undetectable		 5iaoC-3tjiA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_F_URFF301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 3tji MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN
(Enterobacter
sp.
638) 		3 / 3 ARG A  15
HIS A  19
ARG A 382
 None
 0.83A 5iaoF-3tjiA:
undetectable		 5iaoF-3tjiA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_0
(CYTOCHROME P450 1A1)		 3tji MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN
(Enterobacter
sp.
638) 		5 / 12 ASN A 260
ASN A 261
PHE A 259
ASP A 232
ILE A 274
 None
None
None
MG  A 601 ( 4.8A)
None
 1.38A 6dwnA-3tjiA:
undetectable		 6dwnA-3tjiA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCO_A_FY5A1003_0
(ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2)		 3tji MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN
(Enterobacter
sp.
638) 		5 / 11 THR A 342
ASN A 343
PHE A 346
THR A  39
VAL A 317
 None
 1.33A 6hcoA-3tjiA:
undetectable
6hcoB-3tjiA:
undetectable		 6hcoA-3tjiA:
21.06
6hcoB-3tjiA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NCS_A_ACTA303_0
(N-ACETYLNEURAMINIC
ACID (SIALIC ACID)
SYNTHETASE)		 3tji MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN
(Enterobacter
sp.
638) 		3 / 3 ILE A  13
THR A  14
PRO A  44
 None
 0.60A 6ncsA-3tjiA:
9.2		 6ncsA-3tjiA:
21.25