SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tjz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4001_1
(SERUM ALBUMIN)		 3tjz ADP-RIBOSYLATION
FACTOR 1
(Saccharomyces
cerevisiae) 		4 / 5 ARG A  99
ALA A 103
ASP A  26
GLY A  24
 None
 1.15A 1e7bA-3tjzA:
undetectable		 1e7bA-3tjzA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_D_NIOD706_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3tjz ADP-RIBOSYLATION
FACTOR 1
(Saccharomyces
cerevisiae) 		4 / 5 GLU A 164
GLY A 165
SER A 162
THR A 161
 None
None
None
GNP  A 201 ( 4.0A)
 0.88A 1icvC-3tjzA:
undetectable
1icvD-3tjzA:
undetectable		 1icvC-3tjzA:
22.27
1icvD-3tjzA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OSV_B_CHCB201_1
(BILE ACID RECEPTOR)		 3tjz COATOMER SUBUNIT
GAMMA
(Bos
taurus) 		5 / 12 LEU B 109
MET B  73
ILE B 104
ILE B 131
MET B  95
 None
 1.40A 1osvB-3tjzB:
undetectable		 1osvB-3tjzB:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 3tjz ADP-RIBOSYLATION
FACTOR 1
(Saccharomyces
cerevisiae) 		5 / 12 THR A  48
GLY A  29
GLY A  27
GLY A  70
ASP A 129
 MG  A 202 ( 3.0A)
GNP  A 201 (-3.0A)
GNP  A 201 (-3.4A)
GNP  A 201 (-3.6A)
GNP  A 201 (-2.9A)
 0.98A 2b25A-3tjzA:
undetectable		 2b25A-3tjzA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YZQ_A_SAMA6075_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN PH1780)		 3tjz COATOMER SUBUNIT
GAMMA
(Bos
taurus) 		5 / 12 ILE B 131
ASP B 133
THR B 135
VAL B 105
ILE B 104
 None
 0.94A 2yzqA-3tjzB:
undetectable		 2yzqA-3tjzB:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		 3tjz COATOMER SUBUNIT
GAMMA
(Bos
taurus) 		4 / 7 ARG B 309
ARG B 234
GLU B 269
SER B 272
 None
 1.12A 2zt7A-3tjzB:
undetectable		 2zt7A-3tjzB:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 3tjz ADP-RIBOSYLATION
FACTOR 1
COATOMER SUBUNIT
GAMMA
(Bos
taurus;
Saccharomyces
cerevisiae) 		4 / 6 HIS A  80
THR B  67
PHE B  70
LEU A  77
 None
 1.11A 3bgdA-3tjzA:
undetectable		 3bgdA-3tjzA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3tjz ADP-RIBOSYLATION
FACTOR 1
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 145
SER A  94
VAL A  23
GLY A  24
 None
 0.96A 4klrB-3tjzA:
4.3		 4klrB-3tjzA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 3tjz COATOMER SUBUNIT
GAMMA
(Bos
taurus) 		4 / 6 ARG B 309
ARG B 234
GLU B 269
SER B 272
 None
 1.14A 4kr3A-3tjzB:
undetectable		 4kr3A-3tjzB:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP4_A_COCA706_1
(DOPAMINE TRANSPORTER)		 3tjz ADP-RIBOSYLATION
FACTOR 1
(Saccharomyces
cerevisiae) 		5 / 11 PHE A 124
ALA A 120
VAL A  65
ASP A  67
GLY A 169
 None
None
None
MG  A 202 (-3.2A)
None
 1.00A 4xp4A-3tjzA:
undetectable		 4xp4A-3tjzA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YVN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 3tjz ADP-RIBOSYLATION
FACTOR 1
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 111
GLN A 108
LEU A 143
LEU A 145
 None
 1.14A 5yvnA-3tjzA:
undetectable		 5yvnA-3tjzA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11803_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		 3tjz COATOMER SUBUNIT
GAMMA
(Bos
taurus) 		3 / 3 SER B 212
LYS B 213
SER B 216
 None
 0.74A 6az3P-3tjzB:
undetectable		 6az3P-3tjzB:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)		 3tjz ADP-RIBOSYLATION
FACTOR 1
(Saccharomyces
cerevisiae) 		5 / 9 LEU A  34
MET A  22
SER A 174
LEU A 173
ILE A  20
 None
 1.16A 6fdyU-3tjzA:
undetectable		 6fdyU-3tjzA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FDY_U_DB8U302_1
(-)		 3tjz ADP-RIBOSYLATION
FACTOR 1
(Saccharomyces
cerevisiae) 		5 / 9 LEU A  34
MET A  22
VAL A  65
SER A 174
LEU A 173
 None
 1.26A 6fdyU-3tjzA:
undetectable		 6fdyU-3tjzA:
20.60