SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tk1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 3tk1 MEMBRANE
ATPASE/PROTEIN
KINASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 VAL A 170
LEU A 172
GLY A  56
SER A  66
MET A 236
 None
None
None
GDP  A 327 (-4.0A)
None
 1.24A 1fdsA-3tk1A:
3.9		 1fdsA-3tk1A:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3tk1 MEMBRANE
ATPASE/PROTEIN
KINASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 HIS A  54
ALA A  84
ALA A 142
LEU A  42
ILE A  12
 None
 1.15A 2h42B-3tk1A:
undetectable		 2h42B-3tk1A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 3tk1 MEMBRANE
ATPASE/PROTEIN
KINASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 ARG A 108
LEU A 140
GLY A 144
ALA A  84
VAL A  85
 None
 0.99A 2oc8A-3tk1A:
undetectable		 2oc8A-3tk1A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_1
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 3tk1 MEMBRANE
ATPASE/PROTEIN
KINASE
(Mycolicibacteriu
m
thermoresistibil
e) 		3 / 3 GLN A 256
THR A 168
TRP A 248
 None
 1.18A 2rctA-3tk1A:
undetectable		 2rctA-3tk1A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECLA600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3tk1 MEMBRANE
ATPASE/PROTEIN
KINASE
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 8 THR A  30
GLY A 128
ALA A 132
THR A 136
 None
 0.81A 3jusA-3tk1A:
undetectable		 3jusA-3tk1A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3tk1 MEMBRANE
ATPASE/PROTEIN
KINASE
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 8 THR A  30
GLY A 128
ALA A 132
THR A 136
 None
 0.81A 3jusA-3tk1A:
undetectable		 3jusA-3tk1A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEH_B_DAHB786_1
(PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN)		 3tk1 MEMBRANE
ATPASE/PROTEIN
KINASE
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 7 HIS A 204
LEU A 174
GLY A 178
ALA A 211
 None
 0.94A 3tehB-3tk1A:
undetectable		 3tehB-3tk1A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)		 3tk1 MEMBRANE
ATPASE/PROTEIN
KINASE
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 LEU A 181
VAL A 195
GLY A  56
THR A 173
THR A 168
 None
 1.40A 4mubA-3tk1A:
3.6		 4mubA-3tk1A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3tk1 MEMBRANE
ATPASE/PROTEIN
KINASE
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 7 GLU A 151
THR A 152
THR A 168
LEU A 247
 None
 1.05A 4pfjA-3tk1A:
undetectable		 4pfjA-3tk1A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HQA_A_ACRA705_2
(ALPHA-GLUCOSIDASE)		 3tk1 MEMBRANE
ATPASE/PROTEIN
KINASE
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 8 TRP A 248
GLU A 246
HIS A  75
THR A  58
 None
 1.33A 5hqaA-3tk1A:
undetectable		 5hqaA-3tk1A:
20.39