SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tk3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA734_1
(ALPHA AMYLASE)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		4 / 6 ASN A 117
TRP A 121
HIS A 369
GLY A  99
 None
HEM  A 500 (-3.9A)
HEM  A 500 (-3.8A)
None
 1.36A 1mxdA-3tk3A:
undetectable		 1mxdA-3tk3A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		4 / 7 ASN A 117
TRP A 121
HIS A 369
GLY A  99
 None
HEM  A 500 (-3.9A)
HEM  A 500 (-3.8A)
None
 1.37A 1mxgA-3tk3A:
undetectable		 1mxgA-3tk3A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		5 / 12 PRO A 481
THR A 175
GLY A 299
ILE A 356
LEU A 313
 None
None
HEM  A 500 (-3.4A)
None
None
 1.10A 1r30A-3tk3A:
undetectable		 1r30A-3tk3A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		5 / 12 PRO A 481
THR A 175
GLY A 299
ILE A 356
LEU A 313
 None
None
HEM  A 500 (-3.4A)
None
None
 1.10A 1r30B-3tk3A:
undetectable		 1r30B-3tk3A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_2
(MINERALOCORTICOID
RECEPTOR)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		4 / 4 LEU A 362
LEU A 392
SER A 393
LEU A  52
 None
 1.14A 1ya3A-3tk3A:
2.3		 1ya3A-3tk3A:
21.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		4 / 7 LEU A 295
PHE A 296
GLY A 299
THR A 303
 None
None
HEM  A 500 (-3.4A)
HEM  A 500 (-3.3A)
 0.39A 2bdmA-3tk3A:
41.1		 2bdmA-3tk3A:
99.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		6 / 11 ARG A  98
ILE A 114
ALA A 298
THR A 302
VAL A 367
PRO A 368
 HEM  A 500 (-2.9A)
HEM  A 500 (-4.0A)
CPZ  A 501 (-3.5A)
CPZ  A 501 ( 3.7A)
HEM  A 500 ( 4.3A)
None
 0.76A 2nnhA-3tk3A:
52.7		 2nnhA-3tk3A:
55.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2NNH_B_9CRB501_1
(CYTOCHROME P450 2C8)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		5 / 9 ARG A  98
ILE A 114
THR A 302
VAL A 367
PRO A 368
 HEM  A 500 (-2.9A)
HEM  A 500 (-4.0A)
CPZ  A 501 ( 3.7A)
HEM  A 500 ( 4.3A)
None
 0.69A 2nnhB-3tk3A:
45.9		 2nnhB-3tk3A:
55.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		5 / 10 ILE A 114
ALA A 298
THR A 302
VAL A 367
PRO A 368
 HEM  A 500 (-4.0A)
CPZ  A 501 (-3.5A)
CPZ  A 501 ( 3.7A)
HEM  A 500 ( 4.3A)
None
 0.75A 2nnjA-3tk3A:
53.6		 2nnjA-3tk3A:
55.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		4 / 7 ALA A 437
TRP A 121
ILE A 435
HIS A 369
 HEM  A 500 (-3.4A)
HEM  A 500 (-3.9A)
None
HEM  A 500 (-3.8A)
 1.12A 2zm7A-3tk3A:
undetectable		 2zm7A-3tk3A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BA0_A_HAEA477_1
(MACROPHAGE
METALLOELASTASE)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		3 / 3 HIS A 354
GLU A 355
HIS A 412
 None
 0.84A 3ba0A-3tk3A:
undetectable		 3ba0A-3tk3A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		5 / 9 VAL A 183
LEU A 288
SER A 248
ILE A 289
GLY A 299
 None
None
None
None
HEM  A 500 (-3.4A)
 0.99A 3cv9A-3tk3A:
32.4		 3cv9A-3tk3A:
26.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E4E_A_4PZA501_1
(CYTOCHROME P450 2E1)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		3 / 3 ALA A 298
THR A 302
CYH A 436
 CPZ  A 501 (-3.5A)
CPZ  A 501 ( 3.7A)
HEM  A 500 (-2.3A)
 0.61A 3e4eA-3tk3A:
48.5		 3e4eA-3tk3A:
49.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E4E_B_4PZB501_1
(CYTOCHROME P450 2E1)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		3 / 3 ALA A 298
THR A 302
CYH A 436
 CPZ  A 501 (-3.5A)
CPZ  A 501 ( 3.7A)
HEM  A 500 (-2.3A)
 0.55A 3e4eB-3tk3A:
54.3		 3e4eB-3tk3A:
49.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS4_A_AZMA702_1
(CARBONIC ANHYDRASE 2)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		4 / 7 VAL A 324
TYR A 348
GLU A 355
PRO A 410
 None
 1.06A 3hs4A-3tk3A:
undetectable		 3hs4A-3tk3A:
19.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KW4_A_TICA600_1
(CYTOCHROME P450 2B4)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		9 / 11 ILE A 114
ILE A 209
PHE A 297
ALA A 298
THR A 302
ILE A 363
VAL A 367
VAL A 477
GLY A 478
 HEM  A 500 (-4.0A)
None
CPZ  A 501 (-4.3A)
CPZ  A 501 (-3.5A)
CPZ  A 501 ( 3.7A)
HEM  A 500 ( 3.9A)
HEM  A 500 ( 4.3A)
None
None
 0.64A 3kw4A-3tk3A:
60.2		 3kw4A-3tk3A:
99.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KW4_A_TICA600_1
(CYTOCHROME P450 2B4)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		9 / 11 ILE A 114
ILE A 209
SER A 210
PHE A 297
ALA A 298
THR A 302
VAL A 367
VAL A 477
GLY A 478
 HEM  A 500 (-4.0A)
None
None
CPZ  A 501 (-4.3A)
CPZ  A 501 (-3.5A)
CPZ  A 501 ( 3.7A)
HEM  A 500 ( 4.3A)
None
None
 0.72A 3kw4A-3tk3A:
60.2		 3kw4A-3tk3A:
99.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_A_4CHA191_0
(DEHALOPEROXIDASE A)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		4 / 6 PHE A 408
HIS A 319
THR A 321
VAL A 324
 None
 1.10A 3lb3A-3tk3A:
undetectable		 3lb3A-3tk3A:
13.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		8 / 10 VAL A 104
PHE A 108
ILE A 209
ALA A 298
THR A 302
ILE A 363
VAL A 367
VAL A 477
 None
None
None
CPZ  A 501 (-3.5A)
CPZ  A 501 ( 3.7A)
HEM  A 500 ( 3.9A)
HEM  A 500 ( 4.3A)
None
 0.53A 3me6A-3tk3A:
62.9		 3me6A-3tk3A:
99.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		6 / 10 VAL A 104
PHE A 108
ILE A 209
PHE A 297
ALA A 298
THR A 302
 None
None
None
CPZ  A 501 (-4.3A)
CPZ  A 501 (-3.5A)
CPZ  A 501 ( 3.7A)
 1.05A 3me6A-3tk3A:
62.9		 3me6A-3tk3A:
99.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		6 / 8 PHE A 108
ILE A 209
ALA A 298
THR A 302
VAL A 367
VAL A 477
 None
None
CPZ  A 501 (-3.5A)
CPZ  A 501 ( 3.7A)
HEM  A 500 ( 4.3A)
None
 0.46A 3me6B-3tk3A:
62.9		 3me6B-3tk3A:
99.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		7 / 9 VAL A 104
PHE A 108
ILE A 209
ALA A 298
THR A 302
VAL A 367
VAL A 477
 None
None
None
CPZ  A 501 (-3.5A)
CPZ  A 501 ( 3.7A)
HEM  A 500 ( 4.3A)
None
 0.56A 3me6C-3tk3A:
62.9		 3me6C-3tk3A:
99.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		6 / 9 VAL A 104
PHE A 108
ILE A 209
PHE A 297
ALA A 298
THR A 302
 None
None
None
CPZ  A 501 (-4.3A)
CPZ  A 501 (-3.5A)
CPZ  A 501 ( 3.7A)
 1.06A 3me6C-3tk3A:
62.9		 3me6C-3tk3A:
99.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		5 / 9 PHE A 108
ILE A 209
PHE A 297
ALA A 298
THR A 302
 None
None
CPZ  A 501 (-4.3A)
CPZ  A 501 (-3.5A)
CPZ  A 501 ( 3.7A)
 1.24A 3me6D-3tk3A:
62.9		 3me6D-3tk3A:
99.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		7 / 9 VAL A 104
PHE A 108
ILE A 209
ALA A 298
THR A 302
VAL A 367
VAL A 477
 None
None
None
CPZ  A 501 (-3.5A)
CPZ  A 501 ( 3.7A)
HEM  A 500 ( 4.3A)
None
 0.38A 3me6D-3tk3A:
62.9		 3me6D-3tk3A:
99.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T3Q_A_9PLA501_1
(CYTOCHROME P450 2A6)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		5 / 10 PHE A 108
PHE A 115
ALA A 298
THR A 302
ILE A 363
 None
None
CPZ  A 501 (-3.5A)
CPZ  A 501 ( 3.7A)
HEM  A 500 ( 3.9A)
 0.48A 3t3qA-3tk3A:
56.8		 3t3qA-3tk3A:
56.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T3Q_B_9PLB501_1
(CYTOCHROME P450 2A6)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		5 / 10 PHE A 108
PHE A 115
ALA A 298
THR A 302
ILE A 363
 None
None
CPZ  A 501 (-3.5A)
CPZ  A 501 ( 3.7A)
HEM  A 500 ( 3.9A)
 0.57A 3t3qB-3tk3A:
56.8		 3t3qB-3tk3A:
56.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T3Q_B_9PLB501_1
(CYTOCHROME P450 2A6)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		5 / 10 PHE A 108
PHE A 297
ALA A 298
THR A 302
ILE A 363
 None
CPZ  A 501 (-4.3A)
CPZ  A 501 (-3.5A)
CPZ  A 501 ( 3.7A)
HEM  A 500 ( 3.9A)
 1.03A 3t3qB-3tk3A:
56.8		 3t3qB-3tk3A:
56.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T3Q_C_9PLC501_1
(CYTOCHROME P450 2A6)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		5 / 10 PHE A 108
PHE A 115
ALA A 298
THR A 302
ILE A 363
 None
None
CPZ  A 501 (-3.5A)
CPZ  A 501 ( 3.7A)
HEM  A 500 ( 3.9A)
 0.55A 3t3qC-3tk3A:
56.7		 3t3qC-3tk3A:
56.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T3Q_C_9PLC501_1
(CYTOCHROME P450 2A6)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		5 / 10 PHE A 108
PHE A 297
ALA A 298
THR A 302
ILE A 363
 None
CPZ  A 501 (-4.3A)
CPZ  A 501 (-3.5A)
CPZ  A 501 ( 3.7A)
HEM  A 500 ( 3.9A)
 1.06A 3t3qC-3tk3A:
56.7		 3t3qC-3tk3A:
56.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T3Q_D_9PLD501_1
(CYTOCHROME P450 2A6)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		5 / 10 PHE A 108
PHE A 115
ALA A 298
THR A 302
ILE A 363
 None
None
CPZ  A 501 (-3.5A)
CPZ  A 501 ( 3.7A)
HEM  A 500 ( 3.9A)
 0.59A 3t3qD-3tk3A:
56.9		 3t3qD-3tk3A:
56.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T3Q_D_9PLD501_1
(CYTOCHROME P450 2A6)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		5 / 10 PHE A 108
PHE A 297
ALA A 298
THR A 302
ILE A 363
 None
CPZ  A 501 (-4.3A)
CPZ  A 501 (-3.5A)
CPZ  A 501 ( 3.7A)
HEM  A 500 ( 3.9A)
 1.03A 3t3qD-3tk3A:
56.9		 3t3qD-3tk3A:
56.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		4 / 6 PHE A 115
PHE A 297
ALA A 298
THR A 302
 None
CPZ  A 501 (-4.3A)
CPZ  A 501 (-3.5A)
CPZ  A 501 ( 3.7A)
 1.19A 3t3sB-3tk3A:
55.9		 3t3sB-3tk3A:
56.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T3S_D_9PLD1_1
(CYTOCHROME P450 2A13)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		4 / 8 PHE A 108
PHE A 115
ALA A 298
THR A 302
 None
None
CPZ  A 501 (-3.5A)
CPZ  A 501 ( 3.7A)
 0.65A 3t3sD-3tk3A:
55.6		 3t3sD-3tk3A:
56.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T3S_F_9PLF1_1
(CYTOCHROME P450 2A13)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		4 / 8 PHE A 108
PHE A 297
ALA A 298
THR A 302
 None
CPZ  A 501 (-4.3A)
CPZ  A 501 (-3.5A)
CPZ  A 501 ( 3.7A)
 0.97A 3t3sF-3tk3A:
53.7		 3t3sF-3tk3A:
56.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		4 / 6 PHE A 115
PHE A 297
ALA A 298
THR A 302
 None
CPZ  A 501 (-4.3A)
CPZ  A 501 (-3.5A)
CPZ  A 501 ( 3.7A)
 0.61A 3t3zA-3tk3A:
53.9		 3t3zA-3tk3A:
49.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T3Z_B_9PLB501_1
(CYTOCHROME P450 2E1)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		4 / 6 PHE A 115
PHE A 297
ALA A 298
THR A 302
 None
CPZ  A 501 (-4.3A)
CPZ  A 501 (-3.5A)
CPZ  A 501 ( 3.7A)
 0.61A 3t3zB-3tk3A:
53.9		 3t3zB-3tk3A:
49.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T3Z_C_9PLC501_1
(CYTOCHROME P450 2E1)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		4 / 5 PHE A 115
PHE A 297
ALA A 298
THR A 302
 None
CPZ  A 501 (-4.3A)
CPZ  A 501 (-3.5A)
CPZ  A 501 ( 3.7A)
 0.56A 3t3zC-3tk3A:
54.0		 3t3zC-3tk3A:
49.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		4 / 6 PHE A 115
PHE A 297
ALA A 298
THR A 302
 None
CPZ  A 501 (-4.3A)
CPZ  A 501 (-3.5A)
CPZ  A 501 ( 3.7A)
 0.60A 3t3zD-3tk3A:
53.9		 3t3zD-3tk3A:
49.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		7 / 11 ILE A 101
ILE A 114
ILE A 209
ALA A 298
THR A 302
VAL A 367
PRO A 368
 CPZ  A 501 (-4.2A)
HEM  A 500 (-4.0A)
None
CPZ  A 501 (-3.5A)
CPZ  A 501 ( 3.7A)
HEM  A 500 ( 4.3A)
None
 0.94A 3tmzA-3tk3A:
56.8		 3tmzA-3tk3A:
99.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		6 / 11 ILE A 101
ILE A 114
PHE A 115
ILE A 209
ALA A 298
THR A 302
 CPZ  A 501 (-4.2A)
HEM  A 500 (-4.0A)
None
None
CPZ  A 501 (-3.5A)
CPZ  A 501 ( 3.7A)
 1.12A 3tmzA-3tk3A:
56.8		 3tmzA-3tk3A:
99.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		6 / 11 ILE A 101
ILE A 114
PHE A 206
ILE A 209
ALA A 298
THR A 302
 CPZ  A 501 (-4.2A)
HEM  A 500 (-4.0A)
None
None
CPZ  A 501 (-3.5A)
CPZ  A 501 ( 3.7A)
 1.16A 3tmzA-3tk3A:
56.8		 3tmzA-3tk3A:
99.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		6 / 11 ILE A 114
PHE A 108
ILE A 209
ALA A 298
THR A 302
VAL A 367
 HEM  A 500 (-4.0A)
None
None
CPZ  A 501 (-3.5A)
CPZ  A 501 ( 3.7A)
HEM  A 500 ( 4.3A)
 1.16A 3tmzA-3tk3A:
56.8		 3tmzA-3tk3A:
99.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		6 / 11 ILE A 114
PHE A 108
PHE A 206
ILE A 209
ALA A 298
THR A 302
 HEM  A 500 (-4.0A)
None
None
None
CPZ  A 501 (-3.5A)
CPZ  A 501 ( 3.7A)
 1.39A 3tmzA-3tk3A:
56.8		 3tmzA-3tk3A:
99.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		5 / 9 LEU A  70
ILE A 101
ILE A 209
GLN A 215
GLU A 387
 None
CPZ  A 501 (-4.2A)
None
None
None
 1.07A 3tmzA-3tk3A:
56.8		 3tmzA-3tk3A:
99.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UA5_A_06XA502_1
(CYTOCHROME P450 2B6)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		5 / 11 ARG A  73
GLN A 215
PRO A 368
GLU A 387
VAL A 477
 None
 1.44A 3ua5A-3tk3A:
53.5		 3ua5A-3tk3A:
79.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UA5_A_06XA502_1
(CYTOCHROME P450 2B6)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		5 / 11 GLN A 215
GLU A 218
LEU A 219
PRO A 368
VAL A 477
 None
 1.28A 3ua5A-3tk3A:
53.5		 3ua5A-3tk3A:
79.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UA5_A_06XA502_1
(CYTOCHROME P450 2B6)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		5 / 11 GLN A 215
GLU A 218
PRO A 368
GLU A 387
VAL A 477
 None
 1.27A 3ua5A-3tk3A:
53.5		 3ua5A-3tk3A:
79.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UA5_B_06XB502_1
(CYTOCHROME P450 2B6)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		5 / 10 ARG A  73
GLN A 215
LEU A 219
PRO A 368
GLU A 387
 None
 1.07A 3ua5B-3tk3A:
53.6		 3ua5B-3tk3A:
79.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UA5_B_06XB502_1
(CYTOCHROME P450 2B6)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		6 / 10 GLN A 215
GLU A 218
LEU A 219
PRO A 368
GLU A 387
VAL A 477
 None
 1.34A 3ua5B-3tk3A:
53.6		 3ua5B-3tk3A:
79.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UA5_B_06XB502_1
(CYTOCHROME P450 2B6)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		5 / 10 LEU A 219
PRO A 368
GLU A 387
PHE A 389
VAL A 477
 None
 1.06A 3ua5B-3tk3A:
53.6		 3ua5B-3tk3A:
79.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		5 / 6 PHE A  95
ALA A  87
PRO A  31
LEU A  78
VAL A  65
 None
 1.36A 4dubB-3tk3A:
35.0		 4dubB-3tk3A:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		4 / 6 GLY A 478
GLY A 476
GLU A 301
ILE A 209
 None
None
CPZ  A 501 (-3.8A)
None
 0.97A 4fglD-3tk3A:
undetectable		 4fglD-3tk3A:
18.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		8 / 11 ILE A 101
ILE A 114
ILE A 209
LEU A 238
ALA A 298
THR A 302
ILE A 363
VAL A 367
 CPZ  A 501 (-4.2A)
HEM  A 500 (-4.0A)
None
None
CPZ  A 501 (-3.5A)
CPZ  A 501 ( 3.7A)
HEM  A 500 ( 3.9A)
HEM  A 500 ( 4.3A)
 0.52A 4h1nA-3tk3A:
59.7		 4h1nA-3tk3A:
99.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JLT_A_8PRA505_1
(CYTOCHROME P450 2B4)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		5 / 8 ILE A 114
GLU A 218
ALA A 298
VAL A 367
PRO A 368
 HEM  A 500 (-4.0A)
None
CPZ  A 501 (-3.5A)
HEM  A 500 ( 4.3A)
None
 0.64A 4jltA-3tk3A:
60.7		 4jltA-3tk3A:
99.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ1_B_NPSB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		4 / 8 VAL A 320
VAL A 352
ILE A 356
LEU A 470
 None
 0.90A 4jq1B-3tk3A:
undetectable		 4jq1B-3tk3A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		4 / 5 LEU A 470
ARG A 308
PRO A 364
SER A 393
 None
 1.27A 4kmmB-3tk3A:
undetectable		 4kmmB-3tk3A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		4 / 5 PHE A 365
PHE A 389
LEU A  58
PRO A  34
 None
 1.26A 4o8zA-3tk3A:
undetectable		 4o8zA-3tk3A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_1
(ASPARTYL PROTEASE)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		5 / 11 LEU A 295
GLY A 438
ILE A 178
ILE A 146
VAL A 183
 None
HEM  A 500 (-3.5A)
None
None
None
 0.82A 4q1xA-3tk3A:
undetectable		 4q1xA-3tk3A:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		4 / 6 PHE A 488
SER A 461
ALA A 460
LEU A 164
 None
 1.27A 5dzkg-3tk3A:
undetectable
5dzku-3tk3A:
undetectable		 5dzkg-3tk3A:
19.24
5dzku-3tk3A:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB3_A_UEGA202_1
(YFIR)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		4 / 4 LEU A 431
ILE A 435
PRO A 428
LEU A 392
 None
 1.15A 5eb3A-3tk3A:
undetectable		 5eb3A-3tk3A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNX_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		5 / 12 VAL A 113
LEU A 288
SER A 128
PHE A 283
ARG A 122
 HEM  A 500 (-4.7A)
None
None
None
None
 1.40A 5hnxB-3tk3A:
undetectable		 5hnxB-3tk3A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		4 / 8 ASP A 361
TYR A 309
ASN A 406
SER A 475
 None
 1.07A 5l1fA-3tk3A:
undetectable
5l1fB-3tk3A:
undetectable		 5l1fA-3tk3A:
19.48
5l1fB-3tk3A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		4 / 5 LEU A 169
PHE A 171
LEU A 199
PHE A 195
 None
 1.02A 5x1fC-3tk3A:
1.6
5x1fJ-3tk3A:
undetectable		 5x1fC-3tk3A:
18.93
5x1fJ-3tk3A:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		3 / 3 ASP A 166
PHE A 203
ARG A 473
 None
 1.07A 5yw0A-3tk3A:
undetectable		 5yw0A-3tk3A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEO_A_DHIA4_0
((DPR)PY(DHI)PKDL(DGN
))		 3tk3 CYTOCHROME P450 2B4
(Oryctolagus
cuniculus) 		3 / 3 TYR A  69
PRO A  38
LEU A  37
 None
 0.93A 6beoA-3tk3A:
undetectable		 6beoA-3tk3A:
1.88