SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tk8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_1
(PROTEASE RETROPEPSIN)		 3tk8 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E
(Burkholderia
pseudomallei) 		5 / 12 ALA A 189
ILE A 217
VAL A 229
GLY A 202
ILE A 191
 None
 0.86A 2rkgA-3tk8A:
undetectable		 2rkgA-3tk8A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)		 3tk8 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E
(Burkholderia
pseudomallei) 		4 / 6 ASP A 255
TYR A 254
TYR A 263
LEU A 247
 None
 1.01A 2w98A-3tk8A:
undetectable
2w98B-3tk8A:
undetectable		 2w98A-3tk8A:
20.56
2w98B-3tk8A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		 3tk8 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E
(Burkholderia
pseudomallei) 		3 / 3 ILE A 203
SER A 227
SER A 198
 None
 0.64A 3iltH-3tk8A:
undetectable		 3iltH-3tk8A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_1
(PROTEASE)		 3tk8 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E
(Burkholderia
pseudomallei) 		5 / 9 ALA A 189
ILE A 217
VAL A 229
GLY A 202
ILE A 191
 None
 0.90A 3s43A-3tk8A:
undetectable		 3s43A-3tk8A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TYE_B_YTZB902_1
(DIHYDROPTEROATE
SYNTHASE)		 3tk8 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E
(Burkholderia
pseudomallei) 		3 / 3 PHE A 142
LYS A 128
SER A 127
 None
 0.96A 3tyeB-3tk8A:
undetectable		 3tyeB-3tk8A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y1D_D_DVAD5_0
(CYCLIC HEXAPEPTIDE
CYC[NDPOPPKID]
INTEGRASE)		 3tk8 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E
(Burkholderia
pseudomallei) 		3 / 3 GLU A 175
LYS A 193
ASN A 159
 None
EDO  A 320 (-3.3A)
None
 0.90A 4y1dA-3tk8A:
undetectable
4y1dD-3tk8A:
undetectable		 4y1dA-3tk8A:
20.25
4y1dD-3tk8A:
4.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3tk8 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E
(Burkholderia
pseudomallei) 		4 / 7 ILE A 216
GLY A 192
THR A 177
LEU A 197
 None
 0.92A 4zdzA-3tk8A:
undetectable		 4zdzA-3tk8A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3tk8 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E
(Burkholderia
pseudomallei) 		4 / 7 ILE A 216
GLY A 192
THR A 177
LEU A 197
 None
 0.88A 4ze3A-3tk8A:
undetectable		 4ze3A-3tk8A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_1
(HIV-1 PROTEASE)		 3tk8 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E
(Burkholderia
pseudomallei) 		5 / 12 ALA A 189
ILE A 217
VAL A 229
GLY A 202
ILE A 191
 None
 0.82A 5e5kA-3tk8A:
undetectable		 5e5kA-3tk8A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3tk8 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E
(Burkholderia
pseudomallei) 		4 / 8 ILE A 216
GLY A 192
THR A 177
LEU A 197
 None
 0.87A 5esfA-3tk8A:
undetectable		 5esfA-3tk8A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3tk8 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E
(Burkholderia
pseudomallei) 		5 / 12 ILE A 216
VAL A 273
GLY A 192
THR A 177
LEU A 197
 None
 1.16A 5esgA-3tk8A:
undetectable		 5esgA-3tk8A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESJ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3tk8 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E
(Burkholderia
pseudomallei) 		4 / 8 ILE A 216
GLY A 192
THR A 177
LEU A 197
 None
 0.91A 5esjA-3tk8A:
undetectable		 5esjA-3tk8A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)		 3tk8 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E
(Burkholderia
pseudomallei) 		5 / 12 VAL A 215
ILE A 223
LEU A 247
TYR A 287
ALA A 274
 None
 1.29A 5fctB-3tk8A:
undetectable		 5fctB-3tk8A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH614_0
(NADH DEHYDROGENASE,
PUTATIVE)		 3tk8 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E
(Burkholderia
pseudomallei) 		4 / 6 ILE A 156
VAL A 185
TYR A 172
VAL A 173
 None
 0.69A 5jwaH-3tk8A:
undetectable		 5jwaH-3tk8A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_2
(PROTEASE)		 3tk8 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E
(Burkholderia
pseudomallei) 		5 / 12 ALA A 189
ILE A 217
VAL A 229
GLY A 202
ILE A 191
 None
 0.89A 5t8hB-3tk8A:
undetectable		 5t8hB-3tk8A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHD_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3tk8 2,3,4,5-TETRAHYDROPY
RIDINE-2,6-DICARBOXY
LATE
N-SUCCINYLTRANSFERAS
E
(Burkholderia
pseudomallei) 		4 / 4 ARG A  82
PHE A 155
ASP A  77
LEU A 207
 None
None
None
EDO  A 313 ( 4.5A)
 1.46A 5uhdC-3tk8A:
0.0		 5uhdC-3tk8A:
14.31