SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tka'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 3tka RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H
(Escherichia
coli) 		6 / 12 THR A  31
GLY A  33
GLY A  35
GLY A  36
HIS A  37
ASN A 213
 SAM  A 400 (-3.9A)
SAM  A 400 (-3.4A)
SAM  A 400 (-4.3A)
SAM  A 400 (-3.1A)
SAM  A 400 (-3.8A)
None
 1.48A 1n2xB-3tkaA:
33.1		 1n2xB-3tkaA:
39.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 3tka RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H
(Escherichia
coli) 		7 / 12 THR A  31
GLY A  33
GLY A  35
GLY A  36
HIS A  37
ASP A  57
GLY A 103
 SAM  A 400 (-3.9A)
SAM  A 400 (-3.4A)
SAM  A 400 (-4.3A)
SAM  A 400 (-3.1A)
SAM  A 400 (-3.8A)
None
SAM  A 400 (-4.7A)
 0.50A 1n2xB-3tkaA:
33.1		 1n2xB-3tkaA:
39.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3tka RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H
(Escherichia
coli) 		4 / 7 ALA A 137
PHE A 205
ASN A 172
GLU A 182
 None
 1.25A 1t9wA-3tkaA:
undetectable		 1t9wA-3tkaA:
16.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WG8_A_SAMA3142_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3tka RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H
(Escherichia
coli) 		5 / 12 THR A  31
GLY A  33
GLY A  35
PHE A  79
MET A 128
 SAM  A 400 (-3.9A)
SAM  A 400 (-3.4A)
SAM  A 400 (-4.3A)
SAM  A 400 (-3.2A)
SAM  A 400 (-3.3A)
 1.10A 1wg8A-3tkaA:
37.7		 1wg8A-3tkaA:
41.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WG8_A_SAMA3142_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3tka RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H
(Escherichia
coli) 		7 / 12 THR A  31
GLY A  33
GLY A  36
ASP A  57
PHE A  79
SER A 105
MET A 128
 SAM  A 400 (-3.9A)
SAM  A 400 (-3.4A)
SAM  A 400 (-3.1A)
None
SAM  A 400 (-3.2A)
SAM  A 400 (-4.0A)
SAM  A 400 (-3.3A)
 0.60A 1wg8A-3tkaA:
37.7		 1wg8A-3tkaA:
41.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WG8_B_SAMB3141_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3tka RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H
(Escherichia
coli) 		6 / 12 THR A  31
GLY A  33
GLY A  35
PHE A  79
ASP A 101
MET A 128
 SAM  A 400 (-3.9A)
SAM  A 400 (-3.4A)
SAM  A 400 (-4.3A)
SAM  A 400 (-3.2A)
SAM  A 400 (-3.6A)
SAM  A 400 (-3.3A)
 1.01A 1wg8B-3tkaA:
37.2		 1wg8B-3tkaA:
41.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WG8_B_SAMB3141_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3tka RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H
(Escherichia
coli) 		8 / 12 THR A  31
GLY A  33
GLY A  36
ASP A  57
PHE A  79
ASP A 101
SER A 105
MET A 128
 SAM  A 400 (-3.9A)
SAM  A 400 (-3.4A)
SAM  A 400 (-3.1A)
None
SAM  A 400 (-3.2A)
SAM  A 400 (-3.6A)
SAM  A 400 (-4.0A)
SAM  A 400 (-3.3A)
 0.44A 1wg8B-3tkaA:
37.2		 1wg8B-3tkaA:
41.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1WG8_B_SAMB3141_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3tka RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H
(Escherichia
coli) 		5 / 12 THR A  31
GLY A  35
PHE A  79
ASP A 101
SER A 105
 SAM  A 400 (-3.9A)
SAM  A 400 (-4.3A)
SAM  A 400 (-3.2A)
SAM  A 400 (-3.6A)
SAM  A 400 (-4.0A)
 0.85A 1wg8B-3tkaA:
37.2		 1wg8B-3tkaA:
41.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1001_0
(ALDEHYDE
DEHYDROGENASE A)		 3tka RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H
(Escherichia
coli) 		4 / 7 LEU A 152
PHE A 205
ILE A 148
ASN A 172
 None
 0.94A 2opxA-3tkaA:
4.3		 2opxA-3tkaA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_B_SAMB501_1
(SPERMIDINE SYNTHASE)		 3tka RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H
(Escherichia
coli) 		4 / 5 GLN A 108
GLN A  59
ASP A  55
ASP A 101
 SAM  A 400 (-3.4A)
None
SAM  A 400 (-2.8A)
SAM  A 400 (-3.6A)
 1.20A 3bwcB-3tkaA:
13.1		 3bwcB-3tkaA:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT202_1
(PROTEIN S100-A4)		 3tka RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H
(Escherichia
coli) 		5 / 11 ASP A 101
PHE A  79
GLU A 245
LEU A 216
ILE A 248
 SAM  A 400 (-3.6A)
SAM  A 400 (-3.2A)
None
None
None
 1.48A 3ko0Q-3tkaA:
undetectable
3ko0R-3tkaA:
undetectable
3ko0S-3tkaA:
undetectable
3ko0T-3tkaA:
undetectable		 3ko0Q-3tkaA:
15.21
3ko0R-3tkaA:
15.21
3ko0S-3tkaA:
15.21
3ko0T-3tkaA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_3
(PROTEASE)		 3tka RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H
(Escherichia
coli) 		5 / 12 LEU A  42
GLY A  35
GLY A  30
ILE A  54
ILE A  41
 None
SAM  A 400 (-4.3A)
None
None
None
 0.95A 3oxcB-3tkaA:
undetectable		 3oxcB-3tkaA:
14.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 3tka RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H
(Escherichia
coli) 		12 / 12 THR A  31
GLY A  33
ARG A  34
GLY A  36
HIS A  37
ARG A  56
ASP A  57
PHE A  79
SER A 105
GLN A 108
MET A 128
GLU A 218
 SAM  A 400 (-3.9A)
SAM  A 400 (-3.4A)
None
SAM  A 400 (-3.1A)
SAM  A 400 (-3.8A)
SAM  A 400 (-4.8A)
None
SAM  A 400 (-3.2A)
SAM  A 400 (-4.0A)
SAM  A 400 (-3.4A)
SAM  A 400 (-3.3A)
SAM  A 400 (-3.8A)
 0.00A 3tkaA-3tkaA:
49.4		 3tkaA-3tkaA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 3tka RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H
(Escherichia
coli) 		7 / 12 THR A  31
GLY A  35
PHE A  79
SER A 105
GLN A 108
MET A 128
GLU A 218
 SAM  A 400 (-3.9A)
SAM  A 400 (-4.3A)
SAM  A 400 (-3.2A)
SAM  A 400 (-4.0A)
SAM  A 400 (-3.4A)
SAM  A 400 (-3.3A)
SAM  A 400 (-3.8A)
 0.84A 3tkaA-3tkaA:
49.4		 3tkaA-3tkaA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3tka RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H
(Escherichia
coli) 		5 / 12 LEU A  51
GLY A  35
ILE A  67
ASP A  55
LEU A  99
 None
SAM  A 400 (-4.3A)
None
SAM  A 400 (-2.8A)
None
 1.03A 3uj6A-3tkaA:
13.6		 3uj6A-3tkaA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_A_0LAA602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 3tka RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H
(Escherichia
coli) 		4 / 5 LEU A 140
LEU A 183
MET A 126
THR A 204
 None
 1.30A 4do3A-3tkaA:
undetectable		 4do3A-3tkaA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 3tka RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H
(Escherichia
coli) 		3 / 3 THR A 178
ASP A 121
GLU A 185
 None
 0.82A 5fa8A-3tkaA:
13.7		 5fa8A-3tkaA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3tka RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H
(Escherichia
coli) 		5 / 12 ILE A  98
GLY A  93
LEU A  19
GLY A  83
VAL A  86
 None
 0.94A 5i73A-3tkaA:
undetectable		 5i73A-3tkaA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_A_GBMA801_1
(PROLINE--TRNA LIGASE)		 3tka RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H
(Escherichia
coli) 		5 / 12 TYR A  85
LEU A 100
GLU A 218
GLY A  77
ILE A  75
 None
None
SAM  A 400 (-3.8A)
None
None
 1.28A 5ifuA-3tkaA:
undetectable		 5ifuA-3tkaA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN8_A_ACRA1015_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 3tka RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H
(Escherichia
coli) 		5 / 12 ASP A  24
LEU A  91
ILE A  95
ASP A  96
ARG A  22
 None
 1.16A 5nn8A-3tkaA:
undetectable		 5nn8A-3tkaA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3tka RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H
(Escherichia
coli) 		5 / 10 SER A  38
GLY A  35
ARG A  34
ILE A  61
ALA A  60
 None
SAM  A 400 (-4.3A)
None
None
SAM  A 400 ( 4.3A)
 1.23A 5zjiA-3tkaA:
undetectable
5zjiJ-3tkaA:
undetectable		 5zjiA-3tkaA:
16.18
5zjiJ-3tkaA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 3tka RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H
(Escherichia
coli) 		4 / 8 LEU A  19
LEU A  45
HIS A  37
LEU A  40
 None
None
SAM  A 400 (-3.8A)
None
 1.27A 6cbzA-3tkaA:
undetectable		 6cbzA-3tkaA:
11.57