SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tkl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3tkl LIDA PROTEIN,
SUBSTRATE OF THE
DOT/ICM SYSTEM
(Legionella
pneumophila) 		4 / 7 LEU B 434
LEU B 441
MET B 402
GLU B 401
 None
 1.02A 1n13I-3tklB:
undetectable
1n13L-3tklB:
undetectable		 1n13I-3tklB:
10.20
1n13L-3tklB:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3tkl LIDA PROTEIN,
SUBSTRATE OF THE
DOT/ICM SYSTEM
(Legionella
pneumophila) 		4 / 7 LEU B 434
ILE B 395
MET B 402
GLU B 401
 None
 1.06A 2qqdA-3tklB:
undetectable
2qqdE-3tklB:
undetectable		 2qqdA-3tklB:
13.30
2qqdE-3tklB:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3tkl LIDA PROTEIN,
SUBSTRATE OF THE
DOT/ICM SYSTEM
(Legionella
pneumophila) 		4 / 7 LEU B 434
LEU B 441
MET B 402
GLU B 401
 None
 0.97A 2qqdA-3tklB:
undetectable
2qqdE-3tklB:
undetectable		 2qqdA-3tklB:
13.30
2qqdE-3tklB:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3tkl LIDA PROTEIN,
SUBSTRATE OF THE
DOT/ICM SYSTEM
(Legionella
pneumophila) 		4 / 5 LEU B 412
GLN B 405
THR B 408
GLU B 423
 None
 1.41A 3n58C-3tklB:
undetectable		 3n58C-3tklB:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_G_SAMG301_1
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3tkl LIDA PROTEIN,
SUBSTRATE OF THE
DOT/ICM SYSTEM
(Legionella
pneumophila) 		4 / 4 ASP B 336
HIS B 317
SER B 261
GLU B 259
 None
 1.50A 5hfjG-3tklB:
0.0		 5hfjG-3tklB:
23.16