SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tkn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA652_1
(AMYLOMALTASE)		 3tkn NUCLEOPORIN 98
(Mus
musculus) 		4 / 6 TYR C 772
GLY C 771
GLY C 740
TYR C 741
 None
 0.78A 1eswA-3tknC:
undetectable		 1eswA-3tknC:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWI_A_CAMA418_0
(CYTOCHROME P450-CAM)		 3tkn NUCLEOPORIN NUP82
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 206
THR A 200
LEU A 175
ASP A 204
 None
 0.96A 1iwiA-3tknA:
undetectable		 1iwiA-3tknA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		 3tkn NUCLEOPORIN NUP82
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 202
GLY A 203
VAL A 317
LEU A 197
LEU A 327
 None
 1.11A 1ya4B-3tknA:
undetectable		 1ya4B-3tknA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)		 3tkn NUCLEOPORIN NUP82
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 216
LEU A 223
LEU A 225
LEU A 259
 None
 0.97A 1yajD-3tknA:
undetectable		 1yajD-3tknA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YRD_A_CAMA420_0
(CYTOCHROME P450-CAM)		 3tkn NUCLEOPORIN NUP82
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 206
THR A 200
LEU A 175
ASP A 204
 None
 1.04A 1yrdA-3tknA:
undetectable		 1yrdA-3tknA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_G_REAG501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3tkn NUCLEOPORIN NUP82
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 429
GLN A 448
ASN A 425
LEU A 439
PHE A 447
 None
 0.92A 2aclG-3tknA:
undetectable		 2aclG-3tknA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_A_H4BA1290_1
(PTERIDINE REDUCTASE
1)		 3tkn NUCLEOPORIN NUP82
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 294
TYR A 295
LEU A 350
LEU A 327
 None
 0.95A 2bfpA-3tknA:
undetectable		 2bfpA-3tknA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_B_H4BB1290_1
(PTERIDINE REDUCTASE
1)		 3tkn NUCLEOPORIN NUP82
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 294
TYR A 295
LEU A 350
LEU A 327
 None
 0.96A 2bfpB-3tknA:
undetectable		 2bfpB-3tknA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_D_H4BD1290_1
(PTERIDINE REDUCTASE
1)		 3tkn NUCLEOPORIN NUP82
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 294
TYR A 295
LEU A 350
LEU A 327
 None
 1.00A 2bfpD-3tknA:
undetectable		 2bfpD-3tknA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3tkn NUCLEOPORIN NUP82
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 176
ASP A 340
ASN A 171
 None
 0.77A 2bm9D-3tknA:
undetectable		 2bm9D-3tknA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_2
(MINERALOCORTICOID
RECEPTOR)		 3tkn NUCLEOPORIN NUP82
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 216
LEU A 212
LEU A 194
MET A 333
 None
 1.08A 2oaxF-3tknA:
undetectable		 2oaxF-3tknA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 3tkn NUCLEOPORIN NUP82
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 190
ILE A 226
GLN A 252
GLU A 332
 None
 1.20A 2ya7C-3tknA:
5.2		 2ya7C-3tknA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_2
(PHOSPHOLIPASE A2)		 3tkn NUCLEOPORIN 98
(Mus
musculus) 		4 / 6 LYS C 876
GLN C 862
GLY C 860
ARG C 857
 None
 1.03A 3bjwE-3tknC:
undetectable		 3bjwE-3tknC:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3tkn NUCLEOPORIN NUP82
(Saccharomyces
cerevisiae) 		5 / 11 ILE A 287
ILE A 325
VAL A 354
LEU A 324
VAL A 375
 None
 1.09A 3w67A-3tknA:
undetectable		 3w67A-3tknA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		 3tkn NUCLEOPORIN NUP82
(Saccharomyces
cerevisiae) 		4 / 6 LYS A 135
LEU A 216
LEU A 212
THR A 193
 None
 1.26A 4d7bB-3tknA:
undetectable		 4d7bB-3tknA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4A_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3tkn NUCLEOPORIN NUP82
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 206
THR A 200
LEU A 175
ASP A 204
 None
 0.96A 4l4aA-3tknA:
undetectable		 4l4aA-3tknA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2Q_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 3tkn NUCLEOPORIN NUP82
NUCLEOPORIN 98
(Saccharomyces
cerevisiae;
Mus
musculus) 		3 / 3 ASN A 170
SER A 172
ARG C 795
 None
 0.92A 5b2qA-3tknA:
undetectable		 5b2qA-3tknA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 3tkn NUCLEOPORIN NUP82
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 184
ASN A 198
PHE A 285
 None
 0.53A 5dsgB-3tknA:
1.3		 5dsgB-3tknA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		 3tkn NUCLEOPORIN NUP82
(Saccharomyces
cerevisiae) 		4 / 6 LYS A 135
LEU A 216
LEU A 212
THR A 193
 None
 1.27A 5l4iB-3tknA:
undetectable		 5l4iB-3tknA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 3tkn NUCLEOPORIN NUP82
(Saccharomyces
cerevisiae) 		5 / 12 THR A 304
ILE A 305
LEU A 331
PHE A 386
PHE A 328
 None
 1.25A 6a93A-3tknA:
undetectable		 6a93A-3tknA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 3tkn NUCLEOPORIN NUP82
NUCLEOPORIN 98
(Saccharomyces
cerevisiae;
Mus
musculus) 		4 / 5 GLY A 203
ASN A 198
ASP A 204
ARG C 851
 None
 1.39A 6dwdB-3tknA:
undetectable
6dwdD-3tknA:
undetectable		 6dwdB-3tknA:
22.34
6dwdD-3tknA:
22.34