SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tkr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_B_BEZB1162_0
(PEROXIREDOXIN 5)		 3tkr PEROXIREDOXIN-4
(Homo
sapiens) 		4 / 8 PRO A  80
THR A  84
CYH A  87
ARG A 163
 None
 0.57A 1h4oB-3tkrA:
18.8		 1h4oB-3tkrA:
26.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_G_BEZG1162_0
(PEROXIREDOXIN 5)		 3tkr PEROXIREDOXIN-4
(Homo
sapiens) 		4 / 8 PRO A  80
THR A  84
CYH A  87
ARG A 163
 None
 0.57A 1h4oG-3tkrA:
18.6		 1h4oG-3tkrA:
26.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OC3_A_BEZA201_0
(PEROXIREDOXIN 5)		 3tkr PEROXIREDOXIN-4
(Homo
sapiens) 		4 / 8 PRO A  80
THR A  84
CYH A  87
ARG A 163
 None
 0.58A 1oc3A-3tkrA:
18.7		 1oc3A-3tkrA:
27.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 3tkr PEROXIREDOXIN-4
(Homo
sapiens) 		4 / 6 LEU A  64
LEU A  74
TRP A  51
PHE A  76
 None
 1.46A 1rukH-3tkrA:
undetectable
1rukL-3tkrA:
undetectable		 1rukH-3tkrA:
19.93
1rukL-3tkrA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HZQ_A_STRA300_1
(APOLIPOPROTEIN D)		 3tkr PEROXIREDOXIN-4
(Homo
sapiens) 		4 / 7 THR A 106
ALA A  48
TYR A 151
LEU A  66
 None
 1.06A 2hzqA-3tkrA:
undetectable		 2hzqA-3tkrA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_C_BEZC1222_0
(PEROXIREDOXIN 6)		 3tkr PEROXIREDOXIN-4
(Homo
sapiens) 		4 / 8 PRO A  80
THR A  84
VAL A  86
ARG A 163
 None
 0.48A 2v32C-3tkrA:
22.6
2v32D-3tkrA:
23.7		 2v32C-3tkrA:
25.27
2v32D-3tkrA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_C_BEZC1218_0
(PEROXIREDOXIN 6.)		 3tkr PEROXIREDOXIN-4
(Homo
sapiens) 		4 / 8 PRO A  80
THR A  84
VAL A  86
ARG A 163
 None
 0.53A 2v41C-3tkrA:
23.7
2v41D-3tkrA:
23.8		 2v41C-3tkrA:
25.27
2v41D-3tkrA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_D_BEZD1222_0
(PEROXIREDOXIN 6.)		 3tkr PEROXIREDOXIN-4
(Homo
sapiens) 		4 / 8 PRO A  80
THR A  84
VAL A  86
ARG A 163
 None
 0.53A 2v41C-3tkrA:
23.7
2v41D-3tkrA:
23.8		 2v41C-3tkrA:
25.27
2v41D-3tkrA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_H_BEZH1222_0
(PEROXIREDOXIN 6.)		 3tkr PEROXIREDOXIN-4
(Homo
sapiens) 		4 / 8 PRO A  80
THR A  84
VAL A  86
ARG A 163
 None
 0.60A 2v41G-3tkrA:
22.3
2v41H-3tkrA:
22.5		 2v41G-3tkrA:
25.27
2v41H-3tkrA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPS_A_CHDA211_0
(CMER)		 3tkr PEROXIREDOXIN-4
(Homo
sapiens) 		5 / 10 LEU A 132
PHE A  77
GLY A  95
ILE A  92
TRP A 122
 None
 1.38A 3qpsA-3tkrA:
undetectable		 3qpsA-3tkrA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 3tkr PEROXIREDOXIN-4
(Homo
sapiens) 		5 / 9 LEU A 155
LEU A 182
ILE A 177
GLU A  90
VAL A 153
 None
 1.17A 3tmzA-3tkrA:
undetectable		 3tmzA-3tkrA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 3tkr PEROXIREDOXIN-4
(Homo
sapiens) 		5 / 12 LEU A  98
ALA A 110
LEU A  64
LEU A  74
PHE A  94
 None
 1.49A 3vhuA-3tkrA:
undetectable		 3vhuA-3tkrA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD507_1
(HEMOLYTIC LECTIN
CEL-III)		 3tkr PEROXIREDOXIN-4
(Homo
sapiens) 		4 / 5 ASP A 170
GLY A 172
TYR A  73
ASP A 202
 None
 1.43A 3w9tD-3tkrA:
undetectable		 3w9tD-3tkrA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EVR_A_BEZA401_0
(PUTATIVE ABC
TRANSPORTER SUBUNIT,
SUBSTRATE-BINDING
COMPONENT)		 3tkr PEROXIREDOXIN-4
(Homo
sapiens) 		5 / 11 LEU A 162
SER A  40
ALA A  42
PHE A 166
PHE A  78
 None
 1.07A 4evrA-3tkrA:
undetectable		 4evrA-3tkrA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 3tkr PEROXIREDOXIN-4
(Homo
sapiens) 		5 / 11 ILE A 135
HIS A 119
ASP A  82
SER A 112
ALA A 110
 None
 1.30A 6ieyA-3tkrA:
undetectable
6ieyB-3tkrA:
undetectable		 6ieyA-3tkrA:
20.58
6ieyB-3tkrA:
20.58