SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tkt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRE_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3tkt CYTOCHROME P450
(Novosphingobium
aromaticivorans) 		5 / 12 ALA A 157
ASP A 154
PHE A 155
ILE A 143
LEU A 396
 None
 1.15A 1dreA-3tktA:
undetectable		 1dreA-3tktA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3tkt CYTOCHROME P450
(Novosphingobium
aromaticivorans) 		5 / 12 ALA A 157
ASP A 154
PHE A 155
ILE A 143
LEU A 396
 None
 1.06A 1dyiA-3tktA:
undetectable		 1dyiA-3tktA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 3tkt CYTOCHROME P450
(Novosphingobium
aromaticivorans) 		5 / 12 ALA A 157
ASP A 154
PHE A 155
ILE A 143
LEU A 396
 None
 1.12A 1dyiB-3tktA:
undetectable		 1dyiB-3tktA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)		 3tkt CYTOCHROME P450
(Novosphingobium
aromaticivorans) 		5 / 9 LEU A 393
ALA A 309
ALA A 284
LEU A 423
PHE A 155
 None
 1.17A 1nr6A-3tktA:
30.7		 1nr6A-3tktA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3tkt CYTOCHROME P450
(Novosphingobium
aromaticivorans) 		5 / 12 ALA A 157
ASP A 154
PHE A 155
ILE A 143
LEU A 396
 None
 1.02A 1rx7A-3tktA:
undetectable		 1rx7A-3tktA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6U_A_BEZA501_0
(NIKD PROTEIN)		 3tkt CYTOCHROME P450
(Novosphingobium
aromaticivorans) 		4 / 7 HIS A 369
ARG A 311
GLU A 308
TRP A 312
 None
 1.36A 2q6uA-3tktA:
0.0		 2q6uA-3tktA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		 3tkt CYTOCHROME P450
(Novosphingobium
aromaticivorans) 		4 / 6 LEU A 393
LEU A 396
ILE A 305
ARG A 299
 None
 1.10A 2rlfB-3tktA:
undetectable
2rlfC-3tktA:
undetectable		 2rlfB-3tktA:
6.59
2rlfC-3tktA:
6.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_A_SALA1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3tkt CYTOCHROME P450
(Novosphingobium
aromaticivorans) 		4 / 8 SER A 255
THR A 259
LEU A 115
ALA A 247
 None
 0.79A 3ax7A-3tktA:
undetectable		 3ax7A-3tktA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_4
(HIV-1 PROTEASE)		 3tkt CYTOCHROME P450
(Novosphingobium
aromaticivorans) 		4 / 4 LEU A 172
ASP A 238
VAL A 243
THR A 119
 None
 1.25A 3cyxB-3tktA:
undetectable		 3cyxB-3tktA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_A_4PZA501_1
(CYTOCHROME P450 2E1)		 3tkt CYTOCHROME P450
(Novosphingobium
aromaticivorans) 		3 / 3 ALA A 269
THR A 273
CYH A 379
 HEM  A 431 (-3.5A)
HEM  A 431 (-3.8A)
HEM  A 431 (-2.2A)
 0.52A 3e4eA-3tktA:
30.0		 3e4eA-3tktA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E4E_B_4PZB501_1
(CYTOCHROME P450 2E1)		 3tkt CYTOCHROME P450
(Novosphingobium
aromaticivorans) 		3 / 3 ALA A 269
THR A 273
CYH A 379
 HEM  A 431 (-3.5A)
HEM  A 431 (-3.8A)
HEM  A 431 (-2.2A)
 0.46A 3e4eB-3tktA:
29.8		 3e4eB-3tktA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_D_TOPD200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3tkt CYTOCHROME P450
(Novosphingobium
aromaticivorans) 		5 / 9 ALA A 241
VAL A 174
ILE A 264
LEU A 185
PHE A 225
 None
 1.34A 3fl9D-3tktA:
undetectable		 3fl9D-3tktA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3tkt CYTOCHROME P450
(Novosphingobium
aromaticivorans) 		5 / 9 ALA A 241
VAL A 174
ILE A 264
LEU A 185
PHE A 225
 None
 1.37A 3fl9H-3tktA:
undetectable		 3fl9H-3tktA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3tkt CYTOCHROME P450
(Novosphingobium
aromaticivorans) 		3 / 3 ASN A 343
MET A   6
PHE A  53
 None
 1.11A 3g4lD-3tktA:
undetectable		 3g4lD-3tktA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX1_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3tkt CYTOCHROME P450
(Novosphingobium
aromaticivorans) 		4 / 8 GLU A 404
SER A 402
VAL A 400
TRP A 427
 None
 1.37A 3jx1A-3tktA:
undetectable
3jx1B-3tktA:
undetectable		 3jx1A-3tktA:
20.82
3jx1B-3tktA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLY_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3tkt CYTOCHROME P450
(Novosphingobium
aromaticivorans) 		4 / 8 GLU A 404
SER A 402
VAL A 400
TRP A 427
 None
 1.36A 3nlyA-3tktA:
undetectable
3nlyB-3tktA:
0.2		 3nlyA-3tktA:
21.02
3nlyB-3tktA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3tkt CYTOCHROME P450
(Novosphingobium
aromaticivorans) 		4 / 8 SER A 255
THR A 259
LEU A 115
ALA A 247
 None
 0.86A 3ns1L-3tktA:
undetectable		 3ns1L-3tktA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_1
(PROTEASE)		 3tkt CYTOCHROME P450
(Novosphingobium
aromaticivorans) 		5 / 9 GLY A 227
ALA A 229
ILE A 244
GLY A 173
ILE A 264
 None
 0.95A 3s53A-3tktA:
undetectable		 3s53A-3tktA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D32_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3tkt CYTOCHROME P450
(Novosphingobium
aromaticivorans) 		4 / 8 GLU A 404
SER A 402
VAL A 400
TRP A 427
 None
 1.34A 4d32A-3tktA:
undetectable
4d32B-3tktA:
0.2		 4d32A-3tktA:
21.02
4d32B-3tktA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 3tkt CYTOCHROME P450
(Novosphingobium
aromaticivorans) 		5 / 12 GLY A 192
LEU A 423
SER A 422
GLY A 280
ASP A 272
 None
 1.03A 4fp9A-3tktA:
undetectable		 4fp9A-3tktA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 3tkt CYTOCHROME P450
(Novosphingobium
aromaticivorans) 		5 / 12 GLY A 192
LEU A 423
SER A 422
GLY A 280
ASP A 272
 None
 1.04A 4fp9C-3tktA:
undetectable		 4fp9C-3tktA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 3tkt CYTOCHROME P450
(Novosphingobium
aromaticivorans) 		5 / 12 GLY A 192
LEU A 423
SER A 422
GLY A 280
ASP A 272
 None
 1.04A 4fp9F-3tktA:
undetectable		 4fp9F-3tktA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3tkt CYTOCHROME P450
(Novosphingobium
aromaticivorans) 		4 / 6 ILE A  16
THR A 415
VAL A  44
ASP A 338
 None
 0.97A 4iaqA-3tktA:
undetectable		 4iaqA-3tktA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3tkt CYTOCHROME P450
(Novosphingobium
aromaticivorans) 		4 / 7 ILE A  16
THR A 415
VAL A  44
ASP A 338
 None
 0.86A 4iarA-3tktA:
undetectable		 4iarA-3tktA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3tkt CYTOCHROME P450
(Novosphingobium
aromaticivorans) 		4 / 5 GLY A 133
ASP A 132
GLU A 388
VAL A 306
 None
None
HEM  A 431 ( 4.7A)
None
 1.03A 4nkvD-3tktA:
29.7		 4nkvD-3tktA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3tkt CYTOCHROME P450
(Novosphingobium
aromaticivorans) 		5 / 12 ALA A 157
ASP A 154
PHE A 155
ILE A 143
LEU A 396
 None
 1.06A 4qleA-3tktA:
undetectable		 4qleA-3tktA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLF_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3tkt CYTOCHROME P450
(Novosphingobium
aromaticivorans) 		5 / 11 ALA A 157
ASP A 154
PHE A 155
ILE A 143
LEU A 396
 None
 1.10A 4qlfA-3tktA:
undetectable		 4qlfA-3tktA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3tkt CYTOCHROME P450
(Novosphingobium
aromaticivorans) 		5 / 12 ALA A 157
ASP A 154
PHE A 155
ILE A 143
LEU A 396
 None
 1.06A 4qlgA-3tktA:
undetectable		 4qlgA-3tktA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3tkt CYTOCHROME P450
(Novosphingobium
aromaticivorans) 		5 / 12 ALA A 157
ASP A 154
PHE A 155
ILE A 143
LEU A 396
 None
 1.07A 4qlgB-3tktA:
undetectable		 4qlgB-3tktA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RGC_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3tkt CYTOCHROME P450
(Novosphingobium
aromaticivorans) 		5 / 12 ALA A 157
ASP A 154
PHE A 155
ILE A 143
LEU A 396
 None
 1.01A 4rgcA-3tktA:
undetectable		 4rgcA-3tktA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3Y_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3tkt CYTOCHROME P450
(Novosphingobium
aromaticivorans) 		4 / 8 GLU A 404
SER A 402
VAL A 400
TRP A 427
 None
 1.36A 4v3yA-3tktA:
undetectable
4v3yB-3tktA:
undetectable		 4v3yA-3tktA:
21.02
4v3yB-3tktA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3tkt CYTOCHROME P450
(Novosphingobium
aromaticivorans) 		5 / 12 ALA A 157
ASP A 154
PHE A 155
ILE A 143
LEU A 396
 None
 1.04A 4x5gA-3tktA:
undetectable		 4x5gA-3tktA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 3tkt CYTOCHROME P450
(Novosphingobium
aromaticivorans) 		4 / 6 ARG A 299
ARG A 136
ARG A 399
VAL A 391
 None
 1.38A 4xqeB-3tktA:
undetectable		 4xqeB-3tktA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 3tkt CYTOCHROME P450
(Novosphingobium
aromaticivorans) 		5 / 12 PHE A 155
ALA A 282
LEU A 393
SER A 277
VAL A 400
 None
None
None
HEM  A 431 (-3.2A)
None
 1.22A 5uanB-3tktA:
undetectable		 5uanB-3tktA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 3tkt CYTOCHROME P450
(Novosphingobium
aromaticivorans) 		5 / 12 PHE A 155
ALA A 282
LEU A 397
LEU A 393
SER A 277
 None
None
None
None
HEM  A 431 (-3.2A)
 1.43A 5uanB-3tktA:
undetectable		 5uanB-3tktA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2T_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 3tkt CYTOCHROME P450
(Novosphingobium
aromaticivorans) 		4 / 8 PRO A 164
ALA A 157
TRP A 427
ALA A 281
 None
 0.97A 5x2tI-3tktA:
undetectable
5x2tJ-3tktA:
undetectable
5x2tK-3tktA:
undetectable
5x2tL-3tktA:
undetectable		 5x2tI-3tktA:
15.92
5x2tJ-3tktA:
15.67
5x2tK-3tktA:
15.92
5x2tL-3tktA:
15.67