SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tl1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2H42_C_VIAC903_2 (CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE)	3tl1	POLYKETIDE CYCLASE (Streptomyces coelicolor)	3 / 3	ASN A 20 ILE A 11 MET A 106	None	0.74A	2h42C-3tl1A: undetectable	2h42C-3tl1A: 18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QMZ_A_LDPA501_1 (RIBOSYLDIHYDRONICOTI NAMIDE DEHYDROGENASE)	3tl1	POLYKETIDE CYCLASE (Streptomyces coelicolor)	4 / 7	GLU A 34 GLN A 110 ILE A 129 PHE A 88	GOL A 161 (-2.3A) JRO A 160 ( 3.0A) JRO A 160 (-4.5A) JRO A 160 (-4.4A)	1.03A	2qmzA-3tl1A: undetectable 2qmzB-3tl1A: undetectable	2qmzA-3tl1A: 21.50 2qmzB-3tl1A: 21.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2REZ_A_ACTA155_0 (MULTIFUNCTIONAL CYCLASE-DEHYDRATASE- 3-O-METHYL TRANSFERASE TCMN)	3tl1	POLYKETIDE CYCLASE (Streptomyces coelicolor)	4 / 5	TRP A 65 GLY A 86 PRO A 87 PHE A 88	JRO A 160 (-3.6A) None None JRO A 160 (-4.4A)	0.39A	2rezA-3tl1A: 24.6	2rezA-3tl1A: 56.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3VWQ_A_ACAA601_1 (6-AMINOHEXANOATE-DIM ER HYDROLASE)	3tl1	POLYKETIDE CYCLASE (Streptomyces coelicolor)	5 / 12	MET A 137 ALA A 138 TYR A 97 PHE A 32 ILE A 9	None	1.48A	3vwqA-3tl1A: undetectable	3vwqA-3tl1A: 18.34

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2H42_C_VIAC903_2","CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE","3tl1","POLYKETIDE CYCLASE","Streptomyces coelicolor",3,"ASN A  20;ILE A  11;MET A 106","None","0.74A","2h42C-3tl1A:undetectable","2h42C-3tl1A:18.40"],["2QMZ_A_LDPA501_1","RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE;RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE","3tl1","POLYKETIDE CYCLASE","Streptomyces coelicolor",4,"GLU A  34;GLN A 110;ILE A 129;PHE A  88","GOL A 161 (-2.3A);JRO A 160 ( 3.0A);JRO A 160 (-4.5A);JRO A 160 (-4.4A)","1.03A","2qmzA-3tl1A:undetectable;2qmzB-3tl1A:undetectable","2qmzA-3tl1A:21.50;2qmzB-3tl1A:21.50"],["2REZ_A_ACTA155_0","MULTIFUNCTIONAL CYCLASE-DEHYDRATASE-3-O-METHYL TRANSFERASE TCMN","3tl1","POLYKETIDE CYCLASE","Streptomyces coelicolor",4,"TRP A  65;GLY A  86;PRO A  87;PHE A  88","JRO A 160 (-3.6A);None;None;JRO A 160 (-4.4A)","0.39A","2rezA-3tl1A:24.6","2rezA-3tl1A:56.49"],["3VWQ_A_ACAA601_1","6-AMINOHEXANOATE-DIMER HYDROLASE","3tl1","POLYKETIDE CYCLASE","Streptomyces coelicolor",5,"MET A 137;ALA A 138;TYR A  97;PHE A  32;ILE A   9","None","1.48A","3vwqA-3tl1A:undetectable","3vwqA-3tl1A:18.34"]]