SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tl3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 3tl3 SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE
(Mycobacterium
ulcerans) 		5 / 9 GLY A  12
ASP A  36
ILE A  37
ALA A  83
ILE A 109
 None
 0.85A 1cetA-3tl3A:
9.2		 1cetA-3tl3A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3tl3 SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE
(Mycobacterium
ulcerans) 		5 / 9 VAL A  97
GLY A 152
ALA A 158
ILE A 154
SER A 160
 None
 1.33A 1gtnL-3tl3A:
undetectable
1gtnM-3tl3A:
undetectable		 1gtnL-3tl3A:
17.67
1gtnM-3tl3A:
17.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 3tl3 SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE
(Mycobacterium
ulcerans) 		7 / 11 GLY A  12
ALA A  14
SER A  15
ASP A  36
ASP A  56
VAL A  57
ALA A  83
 None
 0.71A 1uayA-3tl3A:
31.9		 1uayA-3tl3A:
58.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 3tl3 SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE
(Mycobacterium
ulcerans) 		7 / 11 GLY A  12
SER A  15
ASP A  36
ARG A  38
ASP A  56
VAL A  57
ALA A  83
 None
 0.85A 1uayA-3tl3A:
31.9		 1uayA-3tl3A:
58.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 3tl3 SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE
(Mycobacterium
ulcerans) 		7 / 10 GLY A  12
ALA A  14
SER A  15
ASP A  36
ASP A  56
VAL A  57
ALA A  83
 None
 0.70A 1uayB-3tl3A:
32.4		 1uayB-3tl3A:
58.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)		 3tl3 SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE
(Mycobacterium
ulcerans) 		5 / 6 ALA A  14
SER A  15
PHE A  52
ASN A  87
ILE A  37
 None
 1.36A 1yc2A-3tl3A:
5.0		 1yc2A-3tl3A:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_B_ADNB402_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 3tl3 SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE
(Mycobacterium
ulcerans) 		5 / 10 GLY A  13
ASP A  36
ILE A  37
ASN A  87
ASP A  56
 None
 1.27A 3ay0B-3tl3A:
5.8		 3ay0B-3tl3A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_2
(PHOSPHOLIPASE A2)		 3tl3 SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE
(Mycobacterium
ulcerans) 		5 / 11 VAL A 117
GLY A 113
ILE A 109
SER A 146
THR A 144
 None
 1.11A 3bjwB-3tl3A:
undetectable		 3bjwB-3tl3A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_2
(PHOSPHOLIPASE A2)		 3tl3 SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE
(Mycobacterium
ulcerans) 		4 / 5 VAL A  79
VAL A   9
GLN A  31
ARG A  49
 None
 1.37A 3bjwH-3tl3A:
undetectable		 3bjwH-3tl3A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_1
(PHOSPHOLIPASE A2)		 3tl3 SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE
(Mycobacterium
ulcerans) 		5 / 11 VAL A 117
GLY A 113
ILE A 109
SER A 146
THR A 144
 None
 1.09A 3bjwE-3tl3A:
undetectable		 3bjwE-3tl3A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_3
(PHOSPHOLIPASE A2)		 3tl3 SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE
(Mycobacterium
ulcerans) 		5 / 12 VAL A 117
GLY A 113
ILE A 109
SER A 146
THR A 144
 None
 1.14A 3bjwF-3tl3A:
undetectable		 3bjwF-3tl3A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_2
(PHOSPHOLIPASE A2)		 3tl3 SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE
(Mycobacterium
ulcerans) 		4 / 5 VAL A  79
VAL A   9
GLN A  31
ARG A  49
 None
 1.28A 3bjwB-3tl3A:
undetectable		 3bjwB-3tl3A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_3
(PHOSPHOLIPASE A2)		 3tl3 SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE
(Mycobacterium
ulcerans) 		5 / 11 VAL A 117
GLY A 113
ILE A 109
SER A 146
THR A 144
 None
 1.20A 3bjwH-3tl3A:
undetectable		 3bjwH-3tl3A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_2
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 3tl3 SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE
(Mycobacterium
ulcerans) 		4 / 4 VAL A   9
ARG A 119
ILE A 182
THR A  11
 None
 1.33A 3cl9A-3tl3A:
undetectable		 3cl9A-3tl3A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB2_A_IBPA3960_1
(LACTOTRANSFERRIN)		 3tl3 SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE
(Mycobacterium
ulcerans) 		4 / 4 GLY A  39
VAL A  43
GLY A  18
THR A  21
 None
 0.65A 3ib2A-3tl3A:
undetectable		 3ib2A-3tl3A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3tl3 SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE
(Mycobacterium
ulcerans) 		5 / 11 VAL A  32
ALA A  50
GLY A  18
ILE A  78
GLY A  13
 None
 1.13A 3zosA-3tl3A:
undetectable
3zosB-3tl3A:
undetectable		 3zosA-3tl3A:
22.26
3zosB-3tl3A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 3tl3 SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE
(Mycobacterium
ulcerans) 		5 / 11 VAL A  32
ALA A  50
GLY A  18
ILE A  78
VAL A  42
 None
 1.10A 3zosA-3tl3A:
undetectable
3zosB-3tl3A:
undetectable		 3zosA-3tl3A:
22.26
3zosB-3tl3A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_A_SAMA401_0
(METHYLTRANSFERASE
MPPJ)		 3tl3 SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE
(Mycobacterium
ulcerans) 		5 / 12 GLY A 113
ARG A 119
ILE A 109
ALA A  83
ASP A  56
 None
 1.23A 4kicA-3tl3A:
6.1		 4kicA-3tl3A:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 3tl3 SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE
(Mycobacterium
ulcerans) 		5 / 11 GLY A  12
GLY A  13
THR A  21
ASP A  36
ASP A  56
 None
 1.11A 4pghA-3tl3A:
5.9		 4pghA-3tl3A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3tl3 SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE
(Mycobacterium
ulcerans) 		5 / 10 ALA A  53
ALA A  66
VAL A 117
GLY A  12
THR A  11
 None
 1.04A 4qvyK-3tl3A:
undetectable
4qvyL-3tl3A:
undetectable		 4qvyK-3tl3A:
22.02
4qvyL-3tl3A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3tl3 SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE
(Mycobacterium
ulcerans) 		5 / 10 ALA A  53
ALA A  66
VAL A 117
GLY A  12
THR A  11
 None
 1.03A 4qvyY-3tl3A:
undetectable
4qvyZ-3tl3A:
undetectable		 4qvyY-3tl3A:
22.02
4qvyZ-3tl3A:
22.85