SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tl8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4003_1
(SERUM ALBUMIN)		 3tl8 EFFECTOR PROTEIN
HOPAB2
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 6 VAL B 324
GLY B 325
ALA B 285
LEU B 289
 None
 0.58A 1e7bB-3tl8B:
undetectable		 1e7bB-3tl8B:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 3tl8 EFFECTOR PROTEIN
HOPAB2
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 10 LEU B 344
VAL B 290
VAL B 324
GLY B 288
LEU B 348
 None
 1.42A 1fkoA-3tl8B:
undetectable		 1fkoA-3tl8B:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6F_C_010C6_0
(INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE)		 3tl8 EFFECTOR PROTEIN
HOPAB2
(Pseudomonas
syringae
group
genomosp.
3) 		3 / 3 ASN B 345
LEU B 341
HIS B 306
 None
 0.80A 2q6fB-3tl8B:
undetectable		 2q6fB-3tl8B:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_A_ADNA1_1
(YTAA PROTEIN)		 3tl8 EFFECTOR PROTEIN
HOPAB2
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 7 PRO B 314
ILE B 313
LEU B 321
ILE B 317
 None
 0.89A 2q83A-3tl8B:
undetectable		 2q83A-3tl8B:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		 3tl8 EFFECTOR PROTEIN
HOPAB2
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 LEU B 341
LEU B 344
ILE B 317
ALA B 302
THR B 301
 None
 1.25A 2v0mC-3tl8B:
undetectable		 2v0mC-3tl8B:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCP_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3tl8 EFFECTOR PROTEIN
HOPAB2
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 10 LEU B 348
ARG B 287
PRO B 328
SER B 329
GLY B 325
 None
 1.47A 3hcpB-3tl8B:
undetectable		 3hcpB-3tl8B:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSG_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3tl8 EFFECTOR PROTEIN
HOPAB2
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 10 LEU B 344
VAL B 290
VAL B 324
GLY B 288
LEU B 348
 None
 1.42A 6bsgA-3tl8B:
undetectable		 6bsgA-3tl8B:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3tl8 EFFECTOR PROTEIN
HOPAB2
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 10 LEU B 344
VAL B 290
VAL B 324
GLY B 288
LEU B 348
 None
 1.38A 6bsiA-3tl8B:
undetectable		 6bsiA-3tl8B:
20.80