SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tlk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_1
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 3tlk FERRIENTEROBACTIN-BI
NDING PERIPLASMIC
PROTEIN
(Escherichia
coli) 		4 / 7 GLN A 215
SER A 213
TYR A 147
GLN A  88
 None
 1.29A 1eiiA-3tlkA:
undetectable		 1eiiA-3tlkA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_B_9CRB165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 3tlk FERRIENTEROBACTIN-BI
NDING PERIPLASMIC
PROTEIN
(Escherichia
coli) 		5 / 12 ILE A  68
LEU A 101
ALA A 140
ILE A 119
ILE A 121
 None
 1.04A 1epbB-3tlkA:
undetectable		 1epbB-3tlkA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_B_RBFB301_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3tlk FERRIENTEROBACTIN-BI
NDING PERIPLASMIC
PROTEIN
(Escherichia
coli) 		5 / 12 ILE A 144
LEU A 143
ALA A 123
SER A  51
LEU A  60
 None
 1.11A 2a58A-3tlkA:
undetectable
2a58B-3tlkA:
undetectable		 2a58A-3tlkA:
21.38
2a58B-3tlkA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_C_RBFC302_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3tlk FERRIENTEROBACTIN-BI
NDING PERIPLASMIC
PROTEIN
(Escherichia
coli) 		5 / 12 ILE A 144
LEU A 143
ALA A 123
SER A  51
LEU A  60
 None
 1.13A 2a58B-3tlkA:
undetectable
2a58C-3tlkA:
undetectable		 2a58B-3tlkA:
21.38
2a58C-3tlkA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_E_RBFE304_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 3tlk FERRIENTEROBACTIN-BI
NDING PERIPLASMIC
PROTEIN
(Escherichia
coli) 		5 / 12 ILE A 144
LEU A 143
ALA A 123
SER A  51
LEU A  60
 None
 1.11A 2a58D-3tlkA:
undetectable
2a58E-3tlkA:
undetectable		 2a58D-3tlkA:
21.38
2a58E-3tlkA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CC8_A_RBFA1067_1
(VNG1446H)		 3tlk FERRIENTEROBACTIN-BI
NDING PERIPLASMIC
PROTEIN
(Escherichia
coli) 		3 / 3 PHE A 300
VAL A 198
TRP A 209
 EB4  A 328 (-4.6A)
EB4  A 328 (-4.0A)
EB4  A 328 (-4.6A)
 0.91A 2cc8A-3tlkA:
undetectable		 2cc8A-3tlkA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 3tlk FERRIENTEROBACTIN-BI
NDING PERIPLASMIC
PROTEIN
(Escherichia
coli) 		5 / 12 GLN A 192
LEU A 257
GLY A 259
ALA A 196
VAL A 198
 None
None
None
None
EB4  A 328 (-4.0A)
 1.00A 2oc8A-3tlkA:
undetectable		 2oc8A-3tlkA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 3tlk FERRIENTEROBACTIN-BI
NDING PERIPLASMIC
PROTEIN
(Escherichia
coli) 		5 / 12 ILE A 145
LEU A 155
GLY A 160
GLN A 168
ILE A 162
 None
 1.31A 2ogyA-3tlkA:
undetectable		 2ogyA-3tlkA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 3tlk FERRIENTEROBACTIN-BI
NDING PERIPLASMIC
PROTEIN
(Escherichia
coli) 		3 / 3 ASN A  77
ARG A  78
ASP A 268
 EB4  A 328 (-3.5A)
EB4  A 328 ( 3.5A)
None
 0.94A 2qe6A-3tlkA:
undetectable		 2qe6A-3tlkA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 3tlk FERRIENTEROBACTIN-BI
NDING PERIPLASMIC
PROTEIN
(Escherichia
coli) 		3 / 3 ASN A  77
ARG A  78
ASP A 268
 EB4  A 328 (-3.5A)
EB4  A 328 ( 3.5A)
None
 0.95A 2qe6B-3tlkA:
undetectable		 2qe6B-3tlkA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VX9_A_RBFA1064_1
(DODECIN)		 3tlk FERRIENTEROBACTIN-BI
NDING PERIPLASMIC
PROTEIN
(Escherichia
coli) 		3 / 3 PHE A 300
VAL A 198
TRP A 209
 EB4  A 328 (-4.6A)
EB4  A 328 (-4.0A)
EB4  A 328 (-4.6A)
 0.90A 2vx9A-3tlkA:
undetectable		 2vx9A-3tlkA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA279_0
(UNIVERSAL STRESS
PROTEIN)		 3tlk FERRIENTEROBACTIN-BI
NDING PERIPLASMIC
PROTEIN
(Escherichia
coli) 		4 / 4 SER A 122
SER A  51
THR A  52
SER A  53
 None
 1.49A 3loqA-3tlkA:
4.6		 3loqA-3tlkA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3tlk FERRIENTEROBACTIN-BI
NDING PERIPLASMIC
PROTEIN
(Escherichia
coli) 		4 / 5 GLY A  71
THR A  57
ILE A  68
VAL A  67
 None
 0.74A 3wriA-3tlkA:
undetectable		 3wriA-3tlkA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 3tlk FERRIENTEROBACTIN-BI
NDING PERIPLASMIC
PROTEIN
(Escherichia
coli) 		4 / 5 GLY A  71
THR A  57
ILE A  68
VAL A  67
 None
 0.73A 3wriB-3tlkA:
undetectable		 3wriB-3tlkA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA602_1
(SERUM ALBUMIN)		 3tlk FERRIENTEROBACTIN-BI
NDING PERIPLASMIC
PROTEIN
(Escherichia
coli) 		4 / 6 ALA A  93
ASP A  81
LEU A  61
SER A  51
 None
 0.76A 4ot2A-3tlkA:
undetectable		 4ot2A-3tlkA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3tlk FERRIENTEROBACTIN-BI
NDING PERIPLASMIC
PROTEIN
(Escherichia
coli) 		4 / 6 GLU A 212
THR A 210
GLN A 237
ASN A 146
 None
 1.30A 4pfjB-3tlkA:
2.3		 4pfjB-3tlkA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_1
(THYMIDYLATE SYNTHASE)		 3tlk FERRIENTEROBACTIN-BI
NDING PERIPLASMIC
PROTEIN
(Escherichia
coli) 		3 / 3 ASN A  77
ASP A 127
GLY A 126
 EB4  A 328 (-3.5A)
EB4  A 328 (-3.5A)
EB4  A 328 (-3.4A)
 0.56A 5fctB-3tlkA:
undetectable		 5fctB-3tlkA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 3tlk FERRIENTEROBACTIN-BI
NDING PERIPLASMIC
PROTEIN
(Escherichia
coli) 		4 / 8 GLN A 269
TYR A 276
LEU A 262
LEU A 264
 None
 0.97A 5hs6A-3tlkA:
3.6		 5hs6A-3tlkA:
23.60