SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tlm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_A_MTXA171_1
(DIHYDROFOLATE
REDUCTASE)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		5 / 12 ALA A 744
LYS A 328
ARG A 324
LEU A 321
THR A 741
 None
 1.24A 1d1gA-3tlmA:
2.4		 1d1gA-3tlmA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_A_ESTA600_1
(ESTROGEN RECEPTOR)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		5 / 11 LEU A 792
LEU A 791
ALA A 305
ILE A  71
LEU A  65
 None
 1.25A 1g50A-3tlmA:
undetectable		 1g50A-3tlmA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JGS_A_SALA256_1
(MULTIPLE ANTIBIOTIC
RESISTANCE PROTEIN
MARR)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		4 / 7 VAL A 596
LEU A 448
LEU A 410
VAL A 593
 None
 0.94A 1jgsA-3tlmA:
undetectable		 1jgsA-3tlmA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_1
(POL POLYPROTEIN)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		5 / 10 VAL A 976
ILE A 839
GLY A 840
GLY A 769
THR A 905
 None
 1.02A 1k6cA-3tlmA:
undetectable		 1k6cA-3tlmA:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_1
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		3 / 3 THR A 741
GLU A 747
ASP A 814
 None
 0.83A 1nt2A-3tlmA:
undetectable		 1nt2A-3tlmA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_A_RBFA100_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		5 / 11 CYH A 471
THR A 447
THR A 457
ILE A 475
VAL A 474
 None
 1.25A 1pkvA-3tlmA:
undetectable
1pkvB-3tlmA:
undetectable		 1pkvA-3tlmA:
7.81
1pkvB-3tlmA:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		5 / 11 ILE A 475
VAL A 474
CYH A 471
THR A 447
THR A 457
 None
 1.27A 1pkvA-3tlmA:
undetectable
1pkvB-3tlmA:
undetectable		 1pkvA-3tlmA:
7.81
1pkvB-3tlmA:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC339_0
(ADP-RIBOSYL CYCLASE)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		3 / 3 GLU A 917
ASN A 918
TRP A 831
 None
 1.24A 1r15C-3tlmA:
undetectable		 1r15C-3tlmA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_D_NCAD349_0
(ADP-RIBOSYL CYCLASE)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		3 / 3 GLU A 917
ASN A 918
TRP A 831
 None
 1.29A 1r15D-3tlmA:
undetectable		 1r15D-3tlmA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_E_NCAE359_0
(ADP-RIBOSYL CYCLASE)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		3 / 3 GLU A 917
ASN A 918
TRP A 831
 None
 1.26A 1r15E-3tlmA:
undetectable		 1r15E-3tlmA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF369_0
(ADP-RIBOSYL CYCLASE)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		3 / 3 GLU A 917
ASN A 918
TRP A 831
 None
 1.25A 1r15F-3tlmA:
undetectable		 1r15F-3tlmA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		4 / 7 ARG A 761
ILE A 760
LEU A 260
GLY A 257
 None
 0.87A 1rtsB-3tlmA:
undetectable		 1rtsB-3tlmA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_1
(CATECHOL-O-METHYLTRA
NSFERASE)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		3 / 3 SER A 404
GLU A 394
ASP A 399
 None
 0.86A 2avdB-3tlmA:
undetectable		 2avdB-3tlmA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		3 / 3 LYS A 352
ASP A 556
CYH A 364
 ACP  A1001 ( 4.3A)
None
None
 1.12A 2br4F-3tlmA:
2.8		 2br4F-3tlmA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HZQ_A_STRA300_1
(APOLIPOPROTEIN D)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		4 / 7 THR A 847
ALA A 306
ASN A 767
LEU A 302
 None
None
CA  A1004 (-3.7A)
None
 1.18A 2hzqA-3tlmA:
undetectable		 2hzqA-3tlmA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		5 / 12 GLY A 701
ALA A 440
ASP A 706
GLY A 703
ILE A 623
 None
None
MG  A1005 ( 4.7A)
None
None
 0.80A 2v0zO-3tlmA:
undetectable		 2v0zO-3tlmA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		5 / 12 PRO A 312
VAL A  62
LEU A  65
ILE A 307
SER A 261
 None
 1.46A 2xrlA-3tlmA:
undetectable		 2xrlA-3tlmA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		4 / 6 ILE A 742
ILE A 752
LEU A 734
MET A 326
 None
 1.17A 3adsA-3tlmA:
undetectable		 3adsA-3tlmA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		4 / 7 VAL A 395
SER A 404
LEU A 448
TRP A 551
 None
 1.12A 3arrA-3tlmA:
undetectable		 3arrA-3tlmA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_B_NCAB302_0
(ADP-RIBOSYL CYCLASE
1)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		4 / 7 LEU A 947
ASP A 962
SER A 901
THR A 905
 None
 0.98A 3dzgB-3tlmA:
undetectable		 3dzgB-3tlmA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		4 / 5 ASP A 426
ILE A 140
VAL A 151
THR A  21
 None
 1.19A 3eigA-3tlmA:
undetectable		 3eigA-3tlmA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_2
(PROTEASE)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		5 / 9 ALA A 846
VAL A 976
ILE A 839
GLY A 769
THR A 905
 None
 1.23A 3el4B-3tlmA:
undetectable		 3el4B-3tlmA:
6.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAZ_A_AINA1202_1
(LACTOTRANSFERRIN)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		3 / 3 GLU A 550
GLY A 554
THR A 553
 None
 0.42A 3iazA-3tlmA:
undetectable		 3iazA-3tlmA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_H_SAMH226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		5 / 12 LEU A 448
GLY A 594
PRO A 517
LEU A 379
ILE A 369
 None
 1.02A 3ku1H-3tlmA:
2.6		 3ku1H-3tlmA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_B_URFB400_1
(URIDINE
PHOSPHORYLASE 1)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		4 / 8 GLY A  17
GLN A  28
LEU A  13
ILE A 222
 None
 0.85A 3nbqB-3tlmA:
undetectable		 3nbqB-3tlmA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_C_URFC400_1
(URIDINE
PHOSPHORYLASE 1)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		4 / 8 GLY A  17
GLN A  28
LEU A  13
ILE A 222
 None
 0.85A 3nbqC-3tlmA:
undetectable		 3nbqC-3tlmA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		5 / 11 ILE A 222
PRO A 147
ILE A 145
VAL A 151
VAL A 129
 None
 1.16A 3rf4B-3tlmA:
undetectable
3rf4C-3tlmA:
undetectable		 3rf4B-3tlmA:
9.86
3rf4C-3tlmA:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		4 / 8 ASP A 706
ASP A 351
GLY A 354
ARG A 559
 MG  A1005 ( 4.7A)
ACP  A1001 ( 2.3A)
MG  A1005 ( 4.6A)
ACP  A1001 (-3.2A)
 1.01A 3s3nA-3tlmA:
undetectable		 3s3nA-3tlmA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_G_CLMG221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		5 / 12 LEU A 690
VAL A 347
PHE A 675
ALA A 672
CYH A 669
 None
 1.50A 3u9fG-3tlmA:
undetectable
3u9fH-3tlmA:
undetectable		 3u9fG-3tlmA:
11.85
3u9fH-3tlmA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_B_NCTB501_1
(CYTOCHROME P450 2A6)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		4 / 7 PHE A 759
ASN A 795
GLY A 800
THR A 804
 None
CA  A1003 (-3.7A)
None
None
 1.01A 4ejjB-3tlmA:
undetectable		 4ejjB-3tlmA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		4 / 5 SER A 350
GLY A 701
THR A 357
ASP A 706
 None
None
None
MG  A1005 ( 4.7A)
 1.14A 4eohA-3tlmA:
undetectable		 4eohA-3tlmA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		4 / 7 GLU A  45
GLU A  44
GLY A 233
ARG A 236
 None
 1.07A 4fgzA-3tlmA:
undetectable		 4fgzA-3tlmA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		3 / 3 ASP A 600
ARG A 677
THR A 357
 None
ACP  A1001 (-3.3A)
None
 0.64A 4i13A-3tlmA:
undetectable		 4i13A-3tlmA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_B_SUZB201_1
(TRANSTHYRETIN)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		4 / 8 SER A 338
ALA A 320
LEU A 336
THR A 323
 None
 0.97A 4iklA-3tlmA:
undetectable
4iklB-3tlmA:
undetectable		 4iklA-3tlmA:
9.43
4iklB-3tlmA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		5 / 11 ILE A 742
ALA A 745
LEU A 734
ALA A 331
VAL A 620
 None
 1.13A 4nqaA-3tlmA:
undetectable		 4nqaA-3tlmA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		3 / 3 ASP A 600
ARG A 677
THR A 357
 None
ACP  A1001 (-3.3A)
None
 0.64A 4p3rA-3tlmA:
undetectable		 4p3rA-3tlmA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_B_QDNB602_1
(CYTOCHROME P450 2D6)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		5 / 9 LEU A 166
GLU A  11
PHE A  16
ALA A 224
ALA A   4
 None
 1.21A 4wnuB-3tlmA:
undetectable		 4wnuB-3tlmA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJE_A_TOYA202_1
(AADB)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		4 / 8 ASP A 702
ASP A 351
ASP A 706
ILE A 686
 MG  A1005 (-2.2A)
ACP  A1001 ( 2.3A)
MG  A1005 ( 4.7A)
None
 1.05A 4xjeA-3tlmA:
undetectable		 4xjeA-3tlmA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		5 / 10 GLY A 722
THR A 355
MET A 699
SER A 730
LEU A 710
 None
 1.21A 4yb6A-3tlmA:
undetectable
4yb6E-3tlmA:
undetectable		 4yb6A-3tlmA:
15.91
4yb6E-3tlmA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		5 / 10 GLY A 722
THR A 355
MET A 699
SER A 730
LEU A 710
 None
 1.22A 4yb6B-3tlmA:
undetectable
4yb6C-3tlmA:
1.3		 4yb6B-3tlmA:
15.91
4yb6C-3tlmA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_C_HISC302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		5 / 10 GLY A 722
THR A 355
MET A 699
SER A 730
LEU A 710
 None
 1.22A 4yb6C-3tlmA:
undetectable
4yb6F-3tlmA:
undetectable		 4yb6C-3tlmA:
15.91
4yb6F-3tlmA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		5 / 10 MET A 699
SER A 730
LEU A 710
GLY A 722
THR A 355
 None
 1.23A 4yb6A-3tlmA:
undetectable
4yb6D-3tlmA:
undetectable		 4yb6A-3tlmA:
15.91
4yb6D-3tlmA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_E_HISE302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		5 / 10 MET A 699
SER A 730
LEU A 710
GLY A 722
THR A 355
 None
 1.22A 4yb6D-3tlmA:
undetectable
4yb6E-3tlmA:
undetectable		 4yb6D-3tlmA:
15.91
4yb6E-3tlmA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		5 / 10 MET A 699
SER A 730
LEU A 710
GLY A 722
THR A 355
 None
 1.22A 4yb6B-3tlmA:
undetectable
4yb6F-3tlmA:
undetectable		 4yb6B-3tlmA:
15.91
4yb6F-3tlmA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CFS_A_TOYA203_1
(AAD(2''),GENTAMICIN
2''-NUCLEOTIDYLTRANS
FERASE,GENTAMICIN
RESISTANCE PROTEIN)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		4 / 8 ASP A 702
ASP A 351
ASP A 706
ILE A 686
 MG  A1005 (-2.2A)
ACP  A1001 ( 2.3A)
MG  A1005 ( 4.7A)
None
 1.05A 5cfsA-3tlmA:
undetectable		 5cfsA-3tlmA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		4 / 6 PHE A  92
SER A  72
ALA A  69
LEU A 792
 None
 1.20A 5dzkB-3tlmA:
undetectable
5dzkP-3tlmA:
undetectable		 5dzkB-3tlmA:
12.23
5dzkP-3tlmA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		4 / 7 PHE A  92
SER A  72
ALA A  69
LEU A 792
 None
 1.09A 5dzkD-3tlmA:
undetectable
5dzkR-3tlmA:
undetectable		 5dzkD-3tlmA:
12.23
5dzkR-3tlmA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		4 / 6 PHE A  92
SER A  72
ALA A  69
LEU A 792
 None
 0.99A 5dzkg-3tlmA:
undetectable
5dzku-3tlmA:
undetectable		 5dzkg-3tlmA:
12.23
5dzku-3tlmA:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		4 / 7 VAL A 794
THR A 798
VAL A 843
THR A 847
 None
CA  A1004 (-3.8A)
None
None
 0.87A 5e4dA-3tlmA:
undetectable
5e4dB-3tlmA:
undetectable		 5e4dA-3tlmA:
12.22
5e4dB-3tlmA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB202_0
(HYDROXYNITRILE LYASE)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		4 / 7 VAL A 843
THR A 847
VAL A 794
THR A 798
 None
None
None
CA  A1004 (-3.8A)
 0.87A 5e4dA-3tlmA:
undetectable
5e4dB-3tlmA:
undetectable		 5e4dA-3tlmA:
12.22
5e4dB-3tlmA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		4 / 6 ARG A 559
ASP A 702
GLY A 354
ASP A 351
 ACP  A1001 (-3.2A)
MG  A1005 (-2.2A)
MG  A1005 ( 4.6A)
ACP  A1001 ( 2.3A)
 1.07A 5hp1A-3tlmA:
undetectable		 5hp1A-3tlmA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		5 / 12 GLU A 714
ARG A 750
ALA A 751
SER A 346
ILE A 618
 None
 1.19A 5igvA-3tlmA:
undetectable		 5igvA-3tlmA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_C_ACTC1403_0
(L-THREONINE
3-DEHYDROGENASE)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		4 / 4 MET A 361
SER A 362
VAL A 363
GLY A 597
 None
 1.48A 5k50C-3tlmA:
0.8		 5k50C-3tlmA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		4 / 6 GLY A 642
GLU A 643
PHE A 641
ILE A 610
 None
 0.78A 5kmfA-3tlmA:
3.6
5kmfC-3tlmA:
0.5		 5kmfA-3tlmA:
14.29
5kmfC-3tlmA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		4 / 8 THR A 804
SER A 935
SER A 939
ALA A 100
 None
 1.11A 5l5fY-3tlmA:
undetectable
5l5fZ-3tlmA:
undetectable		 5l5fY-3tlmA:
12.65
5l5fZ-3tlmA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_E_Z80E401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		5 / 12 ILE A 621
ILE A 686
VAL A 347
THR A 697
GLU A 714
 None
 1.01A 5lg3E-3tlmA:
0.8		 5lg3E-3tlmA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_J_Z80J401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		5 / 12 ILE A 621
ILE A 686
VAL A 347
THR A 697
GLU A 714
 None
 1.02A 5lg3J-3tlmA:
undetectable		 5lg3J-3tlmA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		3 / 3 MET A 511
GLU A 585
ARG A 566
 None
 1.12A 5tjyA-3tlmA:
2.4		 5tjyA-3tlmA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJZ_A_BEZA302_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		3 / 3 MET A 511
GLU A 585
ARG A 566
 None
 1.07A 5tjzA-3tlmA:
2.4		 5tjzA-3tlmA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		5 / 10 VAL A 454
GLY A 405
ILE A 368
LEU A 413
ALA A 414
 None
 0.94A 5vm8B-3tlmA:
2.6		 5vm8B-3tlmA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		5 / 9 GLY A 844
ALA A 846
GLY A 769
GLU A 907
SER A 765
 None
None
None
CA  A1004 (-2.8A)
None
 1.16A 5vw4A-3tlmA:
undetectable		 5vw4A-3tlmA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_C_DAHC60_1
(PUTATIVE CYTOCHROME
C)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		4 / 6 MET A 479
ASN A 469
VAL A 474
LEU A 478
 None
 1.33A 5xdhA-3tlmA:
undetectable
5xdhC-3tlmA:
undetectable		 5xdhA-3tlmA:
7.61
5xdhC-3tlmA:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		4 / 6 SER A 424
ARG A 131
ARG A 134
ASP A 149
 None
 0.86A 5zw4A-3tlmA:
undetectable		 5zw4A-3tlmA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CJK_C_ACTC301_0
(IMMUNOGLOBULIN FAB
LIGHT CHAIN)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		4 / 4 VAL A 733
GLY A 720
ASP A 737
ASP A 702
 None
None
None
MG  A1005 (-2.2A)
 1.48A 6cjkC-3tlmA:
undetectable		 6cjkC-3tlmA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		5 / 12 GLN A 790
LEU A 791
PRO A 788
THR A 777
ILE A 774
 None
 1.20A 6debB-3tlmA:
undetectable		 6debB-3tlmA:
6.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_B_SAMB301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		5 / 12 GLY A 148
THR A 226
ILE A 220
VAL A 153
ILE A 150
 None
 0.92A 6emuB-3tlmA:
undetectable		 6emuB-3tlmA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_C_SAMC301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		5 / 12 GLY A 148
THR A 226
ILE A 220
VAL A 153
ILE A 150
 None
 0.93A 6emuC-3tlmA:
undetectable		 6emuC-3tlmA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		 3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1
(Bos
taurus) 		4 / 6 ASN A 910
TYR A 762
VAL A 843
VAL A 768
 None
 1.30A 6f32B-3tlmA:
undetectable		 6f32B-3tlmA:
19.07