SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tlx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_A_CHDA459_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3tlx ADENYLATE KINASE 2
(Plasmodium
falciparum) 		4 / 6 ASP A 145
LEU A 148
VAL A 149
ILE A 152
 None
 0.52A 1s9qA-3tlxA:
undetectable		 1s9qA-3tlxA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA502_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 3tlx ADENYLATE KINASE 2
(Plasmodium
falciparum) 		3 / 3 LEU A  46
HIS A  56
LYS A  49
 None
 1.04A 1y7iA-3tlxA:
1.6		 1y7iA-3tlxA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_D_AG2D1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 3tlx ADENYLATE KINASE 2
(Plasmodium
falciparum) 		5 / 10 ASP A  61
SER A  58
GLY A  42
ARG A 155
ASP A 190
 None
AMP  A 245 ( 4.9A)
ADP  A 246 (-3.5A)
ADP  A 246 (-3.2A)
None
 1.41A 3n2oC-3tlxA:
undetectable
3n2oD-3tlxA:
undetectable		 3n2oC-3tlxA:
17.28
3n2oD-3tlxA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA603_1
(TRANSPORTER)		 3tlx ADENYLATE KINASE 2
(Plasmodium
falciparum) 		5 / 10 ASP A  61
GLY A  42
SER A  58
GLY A 113
ASP A 191
 None
ADP  A 246 (-3.5A)
AMP  A 245 ( 4.9A)
AMP  A 245 (-4.1A)
None
 1.18A 4mmcA-3tlxA:
undetectable		 4mmcA-3tlxA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_B_SAMB301_0
(PUTATIVE RNA
METHYLASE)		 3tlx ADENYLATE KINASE 2
(Plasmodium
falciparum) 		5 / 12 GLY A 137
ILE A 236
SER A 237
HIS A  52
SER A  51
 None
 1.32A 4pooB-3tlxA:
2.9		 4pooB-3tlxA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_A_HQEA503_1
(CATALASE)		 3tlx ADENYLATE KINASE 2
(Plasmodium
falciparum) 		5 / 9 ILE A  32
PHE A 109
LEU A 111
TYR A 114
LEU A 128
 None
None
None
AMP  A 245 (-4.9A)
None
 1.20A 4qopA-3tlxA:
undetectable		 4qopA-3tlxA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_B_HQEB503_1
(CATALASE)		 3tlx ADENYLATE KINASE 2
(Plasmodium
falciparum) 		5 / 9 ILE A  32
PHE A 109
LEU A 111
TYR A 114
LEU A 128
 None
None
None
AMP  A 245 (-4.9A)
None
 1.20A 4qopB-3tlxA:
undetectable		 4qopB-3tlxA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA602_1
(SERUM ALBUMIN)		 3tlx ADENYLATE KINASE 2
(Plasmodium
falciparum) 		5 / 12 LEU A  48
PHE A 141
LEU A 223
GLY A  40
SER A 237
 None
None
None
ADP  A 246 (-3.0A)
None
 0.95A 4zbrA-3tlxA:
undetectable		 4zbrA-3tlxA:
18.12