SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tlz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_C_ADNC1503_1
(CLASS B ACID
PHOSPHATASE)		 3tlz MCCF
(Escherichia
coli) 		4 / 8 PHE A  22
LEU A 123
GLY A  91
ASP A 119
 None
None
AMP  A 500 (-3.2A)
None
 1.00A 1rmtC-3tlzA:
undetectable		 1rmtC-3tlzA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3tlz MCCF
(Escherichia
coli) 		3 / 3 LEU A 273
LEU A 316
MET A 315
 EDO  A 347 ( 4.3A)
None
None
 0.81A 2itzA-3tlzA:
undetectable		 2itzA-3tlzA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)		 3tlz MCCF
(Escherichia
coli) 		5 / 12 PHE A 159
LEU A 141
ILE A  19
PHE A  48
GLY A 116
 None
 1.30A 2lbdA-3tlzA:
undetectable		 2lbdA-3tlzA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		 3tlz MCCF
(Escherichia
coli) 		4 / 7 ILE A 113
PHE A 159
ILE A 160
PHE A  48
 None
 1.08A 2q6hA-3tlzA:
undetectable		 2q6hA-3tlzA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		 3tlz MCCF
(Escherichia
coli) 		4 / 7 ILE A 113
PHE A 159
ILE A 160
PHE A  48
 None
 1.06A 2qb4A-3tlzA:
undetectable		 2qb4A-3tlzA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 3tlz MCCF
(Escherichia
coli) 		5 / 12 ILE A 215
LEU A 240
ASN A 262
VAL A 264
PRO A 232
 None
None
EDO  A 346 ( 4.7A)
None
None
 1.27A 3dcjA-3tlzA:
undetectable
3dcjB-3tlzA:
undetectable		 3dcjA-3tlzA:
19.21
3dcjB-3tlzA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_R_TFPR201_1
(PROTEIN S100-A4)		 3tlz MCCF
(Escherichia
coli) 		5 / 10 GLY A  91
ILE A 115
CYH A  85
PHE A  22
PHE A  74
 AMP  A 500 (-3.2A)
None
None
None
None
 1.46A 3ko0R-3tlzA:
undetectable
3ko0T-3tlzA:
undetectable		 3ko0R-3tlzA:
14.02
3ko0T-3tlzA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_D_SAMD1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 3tlz MCCF
(Escherichia
coli) 		5 / 10 ILE A 107
THR A 131
VAL A  78
ILE A  86
ILE A 114
 None
 1.30A 3kpbD-3tlzA:
undetectable		 3kpbD-3tlzA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPC_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 3tlz MCCF
(Escherichia
coli) 		5 / 11 ILE A 107
THR A 131
VAL A  78
ILE A  86
ILE A 114
 None
 1.25A 3kpcA-3tlzA:
undetectable		 3kpcA-3tlzA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 3tlz MCCF
(Escherichia
coli) 		4 / 7 GLY A  91
GLY A  92
SER A 118
HIS A 311
 AMP  A 500 (-3.2A)
AMP  A 500 (-3.9A)
AMP  A 500 (-2.5A)
AMP  A 500 (-3.7A)
 0.63A 3o9mA-3tlzA:
undetectable		 3o9mA-3tlzA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_B_BEZB999_0
(CHOLINESTERASE)		 3tlz MCCF
(Escherichia
coli) 		4 / 6 GLY A  91
GLY A  92
SER A 118
HIS A 311
 AMP  A 500 (-3.2A)
AMP  A 500 (-3.9A)
AMP  A 500 (-2.5A)
AMP  A 500 (-3.7A)
 0.69A 3o9mB-3tlzA:
undetectable		 3o9mB-3tlzA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_2
(HIV-1 PROTEASE)		 3tlz MCCF
(Escherichia
coli) 		5 / 10 LEU A 240
ASP A 305
VAL A 303
VAL A 295
ILE A 271
 None
 0.94A 3oxwD-3tlzA:
undetectable		 3oxwD-3tlzA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_1
(ENDOTHIAPEPSIN)		 3tlz MCCF
(Escherichia
coli) 		5 / 12 ILE A 335
LEU A 163
ILE A 107
THR A 135
ILE A 127
 None
 0.99A 3pwwA-3tlzA:
undetectable		 3pwwA-3tlzA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ0_X_DXCX75_0
(CYTOCHROME C7)		 3tlz MCCF
(Escherichia
coli) 		4 / 7 ILE A 272
LYS A 331
PHE A 328
GLY A 206
 None
 1.23A 3sj0X-3tlzA:
undetectable		 3sj0X-3tlzA:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)		 3tlz MCCF
(Escherichia
coli) 		4 / 5 THR A  84
ILE A 113
LYS A 112
PHE A 159
 None
 1.49A 4ac9C-3tlzA:
2.6		 4ac9C-3tlzA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1479_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3tlz MCCF
(Escherichia
coli) 		4 / 5 THR A  84
ILE A 113
LYS A 112
PHE A 159
 None
 1.49A 4acaC-3tlzA:
2.8		 4acaC-3tlzA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G10_A_ACTA301_0
(GLUTATHIONE
S-TRANSFERASE
HOMOLOG)		 3tlz MCCF
(Escherichia
coli) 		4 / 6 PRO A 319
ILE A 272
TYR A 173
PHE A 307
 None
 0.72A 4g10A-3tlzA:
undetectable		 4g10A-3tlzA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 3tlz MCCF
(Escherichia
coli) 		4 / 8 ILE A 271
TYR A 205
LEU A 273
PHE A 256
 None
None
EDO  A 347 ( 4.3A)
None
 0.81A 4v04A-3tlzA:
undetectable		 4v04A-3tlzA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3tlz MCCF
(Escherichia
coli) 		4 / 6 LEU A 197
LYS A 195
LEU A 151
GLU A 147
 EDO  A 345 (-4.4A)
None
None
None
 0.97A 4w5nA-3tlzA:
3.1		 4w5nA-3tlzA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 3tlz MCCF
(Escherichia
coli) 		5 / 12 VAL A 264
LEU A 273
ILE A 271
LYS A 267
VAL A 252
 None
EDO  A 347 ( 4.3A)
None
EDO  A 346 ( 3.7A)
EDO  A 347 ( 4.9A)
 1.09A 4y0qA-3tlzA:
undetectable		 4y0qA-3tlzA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_A_REAA602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 3tlz MCCF
(Escherichia
coli) 		5 / 12 ILE A 215
GLY A 217
THR A 121
ASN A 262
LEU A 222
 None
None
None
EDO  A 346 ( 4.7A)
None
 1.48A 5fhzA-3tlzA:
undetectable		 5fhzA-3tlzA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_2
(PROTEIN-TYROSINE
KINASE 6)		 3tlz MCCF
(Escherichia
coli) 		3 / 3 ILE A 301
MET A 258
ASP A 266
 None
 0.74A 5h2uA-3tlzA:
undetectable		 5h2uA-3tlzA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_D_FK5D201_1
(FK506-BINDING
PROTEIN 1)		 3tlz MCCF
(Escherichia
coli) 		5 / 11 PHE A  42
ILE A 160
ILE A 115
ILE A 113
PHE A  48
 None
 1.20A 5hw8D-3tlzA:
undetectable		 5hw8D-3tlzA:
16.12