SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tm5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		5 / 8 GLU A 248
ASP A 276
THR A 278
PRO A 295
LEU A 309
 SFG  A 401 (-2.6A)
SFG  A 401 (-3.4A)
SFG  A 401 ( 4.1A)
SFG  A 401 ( 4.4A)
None
 1.03A 1hmyA-3tm5A:
9.2		 1hmyA-3tm5A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_1
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		3 / 3 THR A 230
GLU A 248
ASP A 276
 SFG  A 401 (-3.3A)
SFG  A 401 (-2.6A)
SFG  A 401 (-3.4A)
 0.68A 1nt2A-3tm5A:
14.1		 1nt2A-3tm5A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		4 / 8 VAL A 221
ARG A 350
HIS A 348
GLU A 212
 None
 1.27A 1s3zA-3tm5A:
undetectable
1s3zB-3tm5A:
undetectable		 1s3zA-3tm5A:
16.49
1s3zB-3tm5A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN)		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		5 / 12 LEU A  43
LEU A  45
LEU A  75
ALA A  15
ILE A  14
 None
 1.14A 1tw4A-3tm5A:
undetectable		 1tw4A-3tm5A:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_B_9CRB202_1
(RXR-LIKE PROTEIN)		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		5 / 12 ILE A 206
ALA A 207
ALA A 209
LEU A  74
ARG A 191
 None
 1.01A 1xiuB-3tm5A:
undetectable		 1xiuB-3tm5A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X0P_A_ADNA1607_1
(ALCALIGIN
BIOSYNTHESIS PROTEIN)		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		4 / 8 HIS A  76
ILE A  39
ALA A  15
GLU A  12
 None
 0.91A 2x0pA-3tm5A:
undetectable		 2x0pA-3tm5A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		5 / 12 LEU A 178
ILE A 180
ILE A  80
ILE A  82
PHE A 167
 None
 0.48A 2ygoA-3tm5A:
undetectable		 2ygoA-3tm5A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		5 / 9 ILE A 133
ILE A 102
PHE A 176
ILE A 136
VAL A 115
 None
 1.11A 2ygpA-3tm5A:
undetectable		 2ygpA-3tm5A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		5 / 12 ALA A 277
PRO A 295
GLY A 227
THR A 230
GLU A 248
 SFG  A 401 (-3.1A)
SFG  A 401 ( 4.4A)
SFG  A 401 ( 3.7A)
SFG  A 401 (-3.3A)
SFG  A 401 (-2.6A)
 0.56A 2zifA-3tm5A:
3.2		 2zifA-3tm5A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		5 / 12 LEU A 294
ILE A 352
LEU A 361
VAL A 326
ILE A 291
 None
 0.91A 3adxB-3tm5A:
undetectable		 3adxB-3tm5A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		5 / 12 GLY A 227
GLU A 248
LYS A 249
ALA A 277
PRO A 295
 SFG  A 401 ( 3.7A)
SFG  A 401 (-2.6A)
SFG  A 401 (-4.9A)
SFG  A 401 (-3.1A)
SFG  A 401 ( 4.4A)
 0.96A 3fuuA-3tm5A:
14.5		 3fuuA-3tm5A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		5 / 12 GLY A 227
GLU A 248
LYS A 249
ASP A 276
ALA A 277
 SFG  A 401 ( 3.7A)
SFG  A 401 (-2.6A)
SFG  A 401 (-4.9A)
SFG  A 401 (-3.4A)
SFG  A 401 (-3.1A)
 0.87A 3fuuA-3tm5A:
14.5		 3fuuA-3tm5A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRY_A_SAMA300_0
(DIMETHYLADENOSINE
TRANSFERASE)		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		6 / 12 LEU A 202
GLU A 248
ASP A 276
ALA A 277
ASN A 293
PRO A 295
 SFG  A 401 (-4.5A)
SFG  A 401 (-2.6A)
SFG  A 401 (-3.4A)
SFG  A 401 (-3.1A)
SFG  A 401 (-4.4A)
SFG  A 401 ( 4.4A)
 1.21A 3gryA-3tm5A:
15.4		 3gryA-3tm5A:
22.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		12 / 12 ALA A 200
HIS A 201
LEU A 202
MET A 225
GLY A 227
LYS A 249
TYR A 250
HIS A 253
ALA A 277
ASN A 293
PRO A 295
LEU A 309
 SFG  A 401 (-3.9A)
None
SFG  A 401 (-4.5A)
SFG  A 401 (-3.9A)
SFG  A 401 ( 3.7A)
SFG  A 401 (-4.9A)
SFG  A 401 (-4.5A)
SFG  A 401 (-3.9A)
SFG  A 401 (-3.1A)
SFG  A 401 (-4.4A)
SFG  A 401 ( 4.4A)
None
 0.25A 3tm4A-3tm5A:
54.6		 3tm4A-3tm5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TM4_A_SAMA401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		5 / 5 HIS A 198
SER A 228
THR A 230
GLU A 248
ASP A 276
 SFG  A 401 (-3.8A)
SFG  A 401 (-3.6A)
SFG  A 401 (-3.3A)
SFG  A 401 (-2.6A)
SFG  A 401 (-3.4A)
 0.36A 3tm4A-3tm5A:
54.6		 3tm4A-3tm5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		12 / 12 ALA A 200
HIS A 201
LEU A 202
MET A 225
GLY A 227
LYS A 249
TYR A 250
HIS A 253
ALA A 277
ASN A 293
PRO A 295
LEU A 309
 SFG  A 401 (-3.9A)
None
SFG  A 401 (-4.5A)
SFG  A 401 (-3.9A)
SFG  A 401 ( 3.7A)
SFG  A 401 (-4.9A)
SFG  A 401 (-4.5A)
SFG  A 401 (-3.9A)
SFG  A 401 (-3.1A)
SFG  A 401 (-4.4A)
SFG  A 401 ( 4.4A)
None
 0.24A 3tm4B-3tm5A:
55.1		 3tm4B-3tm5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		5 / 5 HIS A 198
SER A 228
THR A 230
GLU A 248
ASP A 276
 SFG  A 401 (-3.8A)
SFG  A 401 (-3.6A)
SFG  A 401 (-3.3A)
SFG  A 401 (-2.6A)
SFG  A 401 (-3.4A)
 0.39A 3tm4B-3tm5A:
55.1		 3tm4B-3tm5A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		7 / 12 MET A 225
GLY A 227
SER A 228
THR A 230
ASN A 293
PRO A 295
LEU A 309
 SFG  A 401 (-3.9A)
SFG  A 401 ( 3.7A)
SFG  A 401 (-3.6A)
SFG  A 401 (-3.3A)
SFG  A 401 (-4.4A)
SFG  A 401 ( 4.4A)
None
 0.67A 3v8vA-3tm5A:
31.1		 3v8vA-3tm5A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		6 / 11 MET A 225
GLY A 227
ASP A 276
ASN A 293
PRO A 295
LEU A 309
 SFG  A 401 (-3.9A)
SFG  A 401 ( 3.7A)
SFG  A 401 (-3.4A)
SFG  A 401 (-4.4A)
SFG  A 401 ( 4.4A)
None
 0.59A 3v8vB-3tm5A:
27.7		 3v8vB-3tm5A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		4 / 5 GLY A 184
THR A  66
VAL A  78
ASP A 181
 None
 1.08A 4eohA-3tm5A:
3.5		 4eohA-3tm5A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_D_MIXD101_1
(DNA TOPOISOMERASE
2-BETA)		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		4 / 6 GLY A 129
GLU A  91
GLN A   9
MET A 358
 None
 1.15A 4g0vB-3tm5A:
undetectable		 4g0vB-3tm5A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		5 / 12 GLY A 227
ILE A 231
ASN A 293
LEU A 294
PRO A 295
 SFG  A 401 ( 3.7A)
None
SFG  A 401 (-4.4A)
None
SFG  A 401 ( 4.4A)
 0.96A 4gc9A-3tm5A:
11.2		 4gc9A-3tm5A:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		6 / 12 LEU A 202
GLY A 227
ILE A 231
LYS A 249
ASN A 293
PRO A 295
 SFG  A 401 (-4.5A)
SFG  A 401 ( 3.7A)
None
SFG  A 401 (-4.9A)
SFG  A 401 (-4.4A)
SFG  A 401 ( 4.4A)
 0.90A 4gc9A-3tm5A:
11.2		 4gc9A-3tm5A:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_2
(MEMBRANE LIPOPROTEIN
TPN38(B))		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		4 / 8 PRO A 156
ASN A 159
PRO A 163
ILE A 146
 None
 0.90A 4iilA-3tm5A:
undetectable		 4iilA-3tm5A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		5 / 12 GLY A 355
PHE A 314
ILE A 339
GLY A 325
LEU A 361
 None
 1.06A 4ze2A-3tm5A:
undetectable		 4ze2A-3tm5A:
22.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5DZK_3_BEZ3801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		4 / 4 LEU A 222
ILE A 291
GLY A 246
ILE A 231
 None
 0.83A 5dzk3-3tm5A:
undetectable
5dzkm-3tm5A:
undetectable		 5dzk3-3tm5A:
40.00
5dzkm-3tm5A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_X_BEZX801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		4 / 5 ILE A 291
GLY A 246
ILE A 231
LEU A 222
 None
 0.89A 5dzki-3tm5A:
undetectable
5dzkj-3tm5A:
undetectable
5dzkx-3tm5A:
undetectable		 5dzki-3tm5A:
21.76
5dzkj-3tm5A:
21.76
5dzkx-3tm5A:
40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Y_BEZY801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		4 / 5 ILE A 291
GLY A 246
ILE A 231
LEU A 222
 None
 0.81A 5dzkd-3tm5A:
undetectable
5dzkk-3tm5A:
undetectable
5dzky-3tm5A:
undetectable		 5dzkd-3tm5A:
20.47
5dzkk-3tm5A:
21.76
5dzky-3tm5A:
40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Z_BEZZ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		4 / 4 ILE A 291
GLY A 246
ILE A 231
LEU A 222
 None
 0.83A 5dzkl-3tm5A:
undetectable
5dzkz-3tm5A:
undetectable		 5dzkl-3tm5A:
21.76
5dzkz-3tm5A:
40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		6 / 12 ASP A 276
ALA A 277
PRO A 295
GLY A 227
THR A 230
GLU A 248
 SFG  A 401 (-3.4A)
SFG  A 401 (-3.1A)
SFG  A 401 ( 4.4A)
SFG  A 401 ( 3.7A)
SFG  A 401 (-3.3A)
SFG  A 401 (-2.6A)
 0.58A 5hfjA-3tm5A:
3.5		 5hfjA-3tm5A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		6 / 12 ALA A 277
PRO A 295
HIS A 198
GLY A 227
SER A 228
THR A 230
 SFG  A 401 (-3.1A)
SFG  A 401 ( 4.4A)
SFG  A 401 (-3.8A)
SFG  A 401 ( 3.7A)
SFG  A 401 (-3.6A)
SFG  A 401 (-3.3A)
 0.65A 5hfjB-3tm5A:
3.3		 5hfjB-3tm5A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		5 / 12 ASP A 276
ALA A 277
PRO A 295
GLY A 227
THR A 230
 SFG  A 401 (-3.4A)
SFG  A 401 (-3.1A)
SFG  A 401 ( 4.4A)
SFG  A 401 ( 3.7A)
SFG  A 401 (-3.3A)
 0.66A 5hfjC-3tm5A:
3.5		 5hfjC-3tm5A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		7 / 12 ASP A 276
ALA A 277
PRO A 295
GLY A 227
SER A 228
THR A 230
GLU A 248
 SFG  A 401 (-3.4A)
SFG  A 401 (-3.1A)
SFG  A 401 ( 4.4A)
SFG  A 401 ( 3.7A)
SFG  A 401 (-3.6A)
SFG  A 401 (-3.3A)
SFG  A 401 (-2.6A)
 0.78A 5hfjD-3tm5A:
3.6		 5hfjD-3tm5A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		6 / 12 ASP A 276
ALA A 277
GLY A 227
SER A 228
THR A 230
GLU A 248
 SFG  A 401 (-3.4A)
SFG  A 401 (-3.1A)
SFG  A 401 ( 3.7A)
SFG  A 401 (-3.6A)
SFG  A 401 (-3.3A)
SFG  A 401 (-2.6A)
 0.57A 5hfjE-3tm5A:
5.8		 5hfjE-3tm5A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		6 / 12 ASP A 276
ALA A 277
PRO A 295
GLY A 227
SER A 228
GLU A 248
 SFG  A 401 (-3.4A)
SFG  A 401 (-3.1A)
SFG  A 401 ( 4.4A)
SFG  A 401 ( 3.7A)
SFG  A 401 (-3.6A)
SFG  A 401 (-2.6A)
 0.67A 5hfjF-3tm5A:
3.4		 5hfjF-3tm5A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		5 / 12 ASP A 276
PRO A 224
GLY A 227
SER A 228
GLU A 248
 SFG  A 401 (-3.4A)
None
SFG  A 401 ( 3.7A)
SFG  A 401 (-3.6A)
SFG  A 401 (-2.6A)
 1.27A 5hfjF-3tm5A:
3.4		 5hfjF-3tm5A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_G_SAMG301_1
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		4 / 4 ASP A 276
HIS A 198
SER A 228
GLU A 248
 SFG  A 401 (-3.4A)
SFG  A 401 (-3.8A)
SFG  A 401 (-3.6A)
SFG  A 401 (-2.6A)
 0.64A 5hfjG-3tm5A:
3.4		 5hfjG-3tm5A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_H_SAMH301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		5 / 12 ASP A 276
ALA A 277
PRO A 295
GLY A 227
THR A 230
 SFG  A 401 (-3.4A)
SFG  A 401 (-3.1A)
SFG  A 401 ( 4.4A)
SFG  A 401 ( 3.7A)
SFG  A 401 (-3.3A)
 0.66A 5hfjH-3tm5A:
4.0		 5hfjH-3tm5A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_1
(PROTEASE PR5-SQV)		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		5 / 9 ALA A 290
ILE A 231
GLY A 246
ILE A 247
PRO A 295
 None
None
None
None
SFG  A 401 ( 4.4A)
 1.04A 5kr2A-3tm5A:
undetectable		 5kr2A-3tm5A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		4 / 8 GLU A 248
LYS A 249
ASP A 276
ASN A 293
 SFG  A 401 (-2.6A)
SFG  A 401 (-4.9A)
SFG  A 401 (-3.4A)
SFG  A 401 (-4.4A)
 0.57A 5mvsB-3tm5A:
12.5		 5mvsB-3tm5A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_A_SALA301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		4 / 5 ALA A 169
VAL A 123
PHE A 176
ILE A 146
 None
 1.03A 5of1A-3tm5A:
undetectable		 5of1A-3tm5A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		3 / 3 MET A 210
ASP A 223
ARG A 194
 None
None
SFG  A 401 ( 4.9A)
 1.17A 5z6jA-3tm5A:
2.7		 5z6jA-3tm5A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A60_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		5 / 12 ILE A 206
ALA A 207
ALA A 209
LEU A  74
ARG A 191
 None
 1.04A 6a60D-3tm5A:
undetectable		 6a60D-3tm5A:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA7_A_TPFA602_0
(CYTOCHROME P450 3A4)		 3tm5 CRYSTAL STRUCTURE OF
TRM14
(Pyrococcus
furiosus) 		4 / 7 ARG A 238
ALA A 236
ILE A 211
ALA A 207
 None
 1.00A 6ma7A-3tm5A:
undetectable		 6ma7A-3tm5A:
12.12