SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tma'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_M_TRPM81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 11 GLY A 196
ALA A 202
ILE A 198
SER A 204
ALA A 203
 None
 1.18A 1gtnM-3tmaA:
undetectable
1gtnN-3tmaA:
undetectable		 1gtnM-3tmaA:
12.54
1gtnN-3tmaA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 8 PHE A 192
ASP A 243
PRO A 262
LEU A 276
 None
 0.87A 1hmyA-3tmaA:
9.2		 1hmyA-3tmaA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_0
(MODIFICATION
METHYLASE RSRI)		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 ASP A 243
PRO A 262
PHE A 192
GLY A 194
SER A 195
 None
 0.87A 1nw5A-3tmaA:
6.2		 1nw5A-3tmaA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAO_A_SAMA245_0
(ERMC'
METHYLTRANSFERASE)		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 GLY A 194
ASP A 218
ASP A 243
ASN A 260
PRO A 262
 None
 0.81A 1qaoA-3tmaA:
13.1		 1qaoA-3tmaA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_T_TRPT81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 10 GLY A 196
ALA A 202
ILE A 198
SER A 204
ALA A 203
 None
 1.19A 1utdT-3tmaA:
undetectable
1utdU-3tmaA:
undetectable		 1utdT-3tmaA:
12.54
1utdU-3tmaA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_B_9CRB202_1
(RXR-LIKE PROTEIN)		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 ALA A 173
ALA A 175
GLN A 174
LEU A  53
ARG A 158
 None
 0.99A 1xiuB-3tmaA:
undetectable		 1xiuB-3tmaA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_ACTB294_0
(GLYCINE
N-METHYLTRANSFERASE)		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 6 ALA A   5
TYR A  23
ILE A  39
LEU A  51
 None
 0.86A 1xvaA-3tmaA:
14.8
1xvaB-3tmaA:
14.4		 1xvaA-3tmaA:
23.12
1xvaB-3tmaA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B9E_A_SAMA1201_0
(NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2)		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 GLY A 196
LEU A 217
ASP A 218
ARG A 221
ASP A 243
 None
 0.61A 2b9eA-3tmaA:
6.6		 2b9eA-3tmaA:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		6 / 12 PHE A 192
GLY A 194
ASP A 218
ASP A 243
PRO A 262
LEU A 276
 None
 0.94A 2hmyB-3tmaA:
9.0		 2hmyB-3tmaA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 ASP A 190
GLY A 194
ASP A 218
ASN A 260
LEU A 276
 None
 0.76A 2nxeA-3tmaA:
18.0		 2nxeA-3tmaA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		6 / 12 ALA A 244
PRO A 262
PHE A 192
GLY A 194
THR A 197
LEU A 217
 None
 0.75A 2zifA-3tmaA:
4.0		 2zifA-3tmaA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 ALA A 244
PRO A 262
PHE A 192
GLY A 194
LEU A 217
 None
 0.71A 2zifB-3tmaA:
4.0		 2zifB-3tmaA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		3 / 3 GLY A 194
ASP A 216
ASP A 243
 None
 0.46A 3ou7C-3tmaA:
12.4		 3ou7C-3tmaA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q87_B_SAMB300_0
(N6 ADENINE SPECIFIC
DNA METHYLASE)		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		6 / 12 ILE A 198
ASP A 216
LEU A 217
ASP A 243
ASN A 260
PRO A 262
 None
 0.84A 3q87B-3tmaA:
15.0		 3q87B-3tmaA:
20.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 LEU A 168
GLY A 194
ALA A 244
PRO A 262
LEU A 276
 None
 0.75A 3tm4A-3tmaA:
34.8		 3tm4A-3tmaA:
30.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 LEU A 168
GLY A 194
ASN A 260
PRO A 262
LEU A 276
 None
 0.85A 3tm4A-3tmaA:
34.8		 3tm4A-3tmaA:
30.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 LEU A 168
GLY A 194
ALA A 244
PRO A 262
LEU A 276
 None
 0.78A 3tm4B-3tmaA:
34.8		 3tm4B-3tmaA:
30.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 LEU A 168
GLY A 194
ASN A 260
PRO A 262
LEU A 276
 None
 0.89A 3tm4B-3tmaA:
34.8		 3tm4B-3tmaA:
30.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		7 / 12 GLY A 194
SER A 195
THR A 197
ASP A 218
ASN A 260
PRO A 262
LEU A 276
 None
 0.72A 3v8vA-3tmaA:
29.8		 3v8vA-3tmaA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		6 / 11 GLY A 194
ASP A 216
ASP A 218
ASN A 260
PRO A 262
LEU A 276
 None
 0.53A 3v8vB-3tmaA:
26.4		 3v8vB-3tmaA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		6 / 11 GLY A 194
ASP A 216
ASP A 243
ASN A 260
PRO A 262
LEU A 276
 None
 0.62A 3v8vB-3tmaA:
26.4		 3v8vB-3tmaA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_1
(PROTEASE)		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 9 LEU A 189
ALA A 259
VAL A 294
LEU A 332
ILE A 257
 None
 1.01A 3wsjA-3tmaA:
undetectable		 3wsjA-3tmaA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 7 PRO A  83
ARG A  61
GLY A 147
VAL A 135
 None
 0.87A 4a3uB-3tmaA:
undetectable		 4a3uB-3tmaA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		6 / 11 ASP A 190
GLY A 194
ILE A 198
ASP A 216
ASN A 260
PRO A 262
 None
 0.68A 4dcmA-3tmaA:
17.1		 4dcmA-3tmaA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_1
(METHYLTRANSFERASE
NSUN4)		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		3 / 3 ASP A 216
ARG A 221
ASP A 243
 None
 0.83A 4fp9C-3tmaA:
14.1		 4fp9C-3tmaA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_1
(METHYLTRANSFERASE
NSUN4)		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		3 / 3 ASP A 216
ARG A 221
ASP A 243
 None
 0.82A 4fp9F-3tmaA:
14.1		 4fp9F-3tmaA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 LEU A 168
GLY A 194
ILE A 198
ASN A 260
PRO A 262
 None
 0.75A 4gc9A-3tmaA:
11.6		 4gc9A-3tmaA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 8 ARG A 136
GLU A  29
ASP A 138
GLU A 100
 None
 1.08A 4gkhF-3tmaA:
2.1		 4gkhF-3tmaA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 LEU A 332
VAL A 294
ALA A 244
PHE A 192
THR A 298
 None
 1.29A 4iaqA-3tmaA:
undetectable		 4iaqA-3tmaA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 8 ASP A 255
SER A 210
ARG A 187
PRO A 184
 None
 1.09A 4uhxA-3tmaA:
undetectable		 4uhxA-3tmaA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_RTZA3009_1
(ALDEHYDE OXIDASE)		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 8 ASP A 255
SER A 210
ARG A 187
PRO A 184
 None
 1.09A 4uhxA-3tmaA:
undetectable		 4uhxA-3tmaA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 11 LEU A 308
LEU A 281
LEU A 304
ALA A 295
LEU A 296
 None
 0.96A 4wg0B-3tmaA:
undetectable
4wg0C-3tmaA:
undetectable
4wg0D-3tmaA:
undetectable		 4wg0B-3tmaA:
4.20
4wg0C-3tmaA:
4.20
4wg0D-3tmaA:
4.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 11 LEU A 308
LEU A 281
LEU A 304
ALA A 295
LEU A 296
 None
 0.97A 4wg0D-3tmaA:
undetectable
4wg0E-3tmaA:
undetectable
4wg0F-3tmaA:
undetectable		 4wg0D-3tmaA:
4.20
4wg0E-3tmaA:
4.20
4wg0F-3tmaA:
4.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 11 ALA A 295
LEU A 296
LEU A 304
LEU A 308
LEU A 281
 None
 0.94A 4wg0C-3tmaA:
undetectable
4wg0D-3tmaA:
undetectable
4wg0E-3tmaA:
undetectable		 4wg0C-3tmaA:
4.20
4wg0D-3tmaA:
4.20
4wg0E-3tmaA:
4.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 11 LEU A 308
LEU A 281
LEU A 304
ALA A 295
LEU A 296
 None
 0.96A 4wg0F-3tmaA:
undetectable
4wg0G-3tmaA:
undetectable
4wg0H-3tmaA:
undetectable		 4wg0F-3tmaA:
4.20
4wg0G-3tmaA:
4.20
4wg0H-3tmaA:
4.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 11 ALA A 295
LEU A 296
LEU A 304
LEU A 308
LEU A 281
 None
 0.95A 4wg0E-3tmaA:
undetectable
4wg0F-3tmaA:
undetectable
4wg0G-3tmaA:
undetectable		 4wg0E-3tmaA:
4.20
4wg0F-3tmaA:
4.20
4wg0G-3tmaA:
4.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_H_CHDH103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 11 LEU A 308
LEU A 281
LEU A 304
ALA A 295
LEU A 296
 None
 0.96A 4wg0H-3tmaA:
undetectable
4wg0I-3tmaA:
undetectable
4wg0J-3tmaA:
undetectable		 4wg0H-3tmaA:
4.20
4wg0I-3tmaA:
4.20
4wg0J-3tmaA:
4.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 11 ALA A 295
LEU A 296
LEU A 304
LEU A 308
LEU A 281
 None
 0.94A 4wg0G-3tmaA:
undetectable
4wg0H-3tmaA:
undetectable
4wg0I-3tmaA:
undetectable		 4wg0G-3tmaA:
4.20
4wg0H-3tmaA:
4.20
4wg0I-3tmaA:
4.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_J_CHDJ103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 11 LEU A 308
LEU A 281
LEU A 304
ALA A 295
LEU A 296
 None
 0.95A 4wg0J-3tmaA:
undetectable
4wg0K-3tmaA:
undetectable
4wg0L-3tmaA:
undetectable		 4wg0J-3tmaA:
4.20
4wg0K-3tmaA:
4.20
4wg0L-3tmaA:
4.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_K_CHDK103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 11 ALA A 295
LEU A 296
LEU A 304
LEU A 308
LEU A 281
 None
 0.97A 4wg0I-3tmaA:
undetectable
4wg0J-3tmaA:
undetectable
4wg0K-3tmaA:
undetectable		 4wg0I-3tmaA:
4.20
4wg0J-3tmaA:
4.20
4wg0K-3tmaA:
4.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 11 ALA A 295
LEU A 296
LEU A 304
LEU A 308
LEU A 281
 None
 0.97A 4wg0K-3tmaA:
undetectable
4wg0L-3tmaA:
undetectable
4wg0M-3tmaA:
undetectable		 4wg0K-3tmaA:
4.20
4wg0L-3tmaA:
4.20
4wg0M-3tmaA:
4.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		3 / 3 LEU A  75
ARG A  77
ARG A 113
 None
None
PO4  A 401 ( 4.5A)
 0.86A 4yiaB-3tmaA:
undetectable		 4yiaB-3tmaA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF402_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 7 LEU A  75
ALA A  78
LEU A 146
ALA A  62
LEU A  66
 None
 1.26A 4z90F-3tmaA:
undetectable
4z90G-3tmaA:
undetectable
4z90H-3tmaA:
undetectable
4z90J-3tmaA:
undetectable		 4z90F-3tmaA:
21.52
4z90G-3tmaA:
21.52
4z90H-3tmaA:
21.52
4z90J-3tmaA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		6 / 12 PHE A 192
GLY A 196
ILE A 198
ALA A 244
PRO A 262
LEU A 276
 None
 1.13A 5e72A-3tmaA:
22.2		 5e72A-3tmaA:
29.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		4 / 4 ASP A 190
GLY A 194
ASP A 216
ASP A 243
 None
 0.53A 5e72A-3tmaA:
22.2		 5e72A-3tmaA:
29.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 10 GLY A 196
ALA A 202
ILE A 198
SER A 204
ALA A 203
 None
 1.19A 5eeuO-3tmaA:
undetectable
5eeuP-3tmaA:
undetectable		 5eeuO-3tmaA:
12.54
5eeuP-3tmaA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 10 GLY A 196
ALA A 202
ILE A 198
SER A 204
ALA A 203
 None
 1.19A 5eevO-3tmaA:
undetectable
5eevP-3tmaA:
undetectable		 5eevO-3tmaA:
12.54
5eevP-3tmaA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 10 GLY A 196
ALA A 202
ILE A 198
SER A 204
ALA A 203
 None
 1.19A 5eewO-3tmaA:
undetectable
5eewP-3tmaA:
undetectable		 5eewO-3tmaA:
12.54
5eewP-3tmaA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 10 GLY A 196
ALA A 202
ILE A 198
SER A 204
ALA A 203
 None
 1.18A 5eexO-3tmaA:
undetectable
5eexP-3tmaA:
undetectable		 5eexO-3tmaA:
12.54
5eexP-3tmaA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 10 GLY A 196
ALA A 202
ILE A 198
SER A 204
ALA A 203
 None
 1.19A 5eeyO-3tmaA:
undetectable
5eeyP-3tmaA:
undetectable		 5eeyO-3tmaA:
12.54
5eeyP-3tmaA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 10 GLY A 196
ALA A 202
ILE A 198
SER A 204
ALA A 203
 None
 1.19A 5eezO-3tmaA:
undetectable
5eezP-3tmaA:
undetectable		 5eezO-3tmaA:
12.54
5eezP-3tmaA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 10 GLY A 196
ALA A 202
ILE A 198
SER A 204
ALA A 203
 None
 1.19A 5ef0O-3tmaA:
undetectable
5ef0P-3tmaA:
undetectable		 5ef0O-3tmaA:
12.54
5ef0P-3tmaA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 10 GLY A 196
ALA A 202
ILE A 198
SER A 204
ALA A 203
 None
 1.19A 5ef1O-3tmaA:
undetectable
5ef1P-3tmaA:
undetectable		 5ef1O-3tmaA:
12.54
5ef1P-3tmaA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 10 GLY A 196
ALA A 202
ILE A 198
SER A 204
ALA A 203
 None
 1.19A 5ef2O-3tmaA:
undetectable
5ef2P-3tmaA:
undetectable		 5ef2O-3tmaA:
12.54
5ef2P-3tmaA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 10 GLY A 196
ALA A 202
ILE A 198
SER A 204
ALA A 203
 None
 1.19A 5ef3O-3tmaA:
undetectable
5ef3P-3tmaA:
undetectable		 5ef3O-3tmaA:
12.54
5ef3P-3tmaA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		6 / 12 ASP A 243
ALA A 244
PRO A 262
PHE A 192
GLY A 194
THR A 197
 None
 0.73A 5hfjA-3tmaA:
3.4		 5hfjA-3tmaA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		6 / 12 ALA A 244
PRO A 262
PHE A 192
GLY A 194
SER A 195
THR A 197
 None
 0.88A 5hfjB-3tmaA:
2.9		 5hfjB-3tmaA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		6 / 12 ASP A 243
ALA A 244
PRO A 262
PHE A 192
GLY A 194
THR A 197
 None
 0.71A 5hfjC-3tmaA:
3.0		 5hfjC-3tmaA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		7 / 12 ASP A 243
ALA A 244
PRO A 262
PHE A 192
GLY A 194
SER A 195
THR A 197
 None
 0.83A 5hfjD-3tmaA:
3.1		 5hfjD-3tmaA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 ASP A 243
ALA A 244
PHE A 192
GLY A 194
SER A 195
 None
 0.68A 5hfjE-3tmaA:
3.5		 5hfjE-3tmaA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 ASP A 243
ALA A 244
PHE A 192
GLY A 194
THR A 197
 None
 0.72A 5hfjE-3tmaA:
3.5		 5hfjE-3tmaA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		6 / 12 ASP A 243
ALA A 244
PRO A 262
PHE A 192
GLY A 194
SER A 195
 None
 0.83A 5hfjF-3tmaA:
3.1		 5hfjF-3tmaA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_G_SAMG301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 ALA A 244
PRO A 262
PHE A 192
GLY A 194
THR A 197
 None
 0.72A 5hfjG-3tmaA:
2.8		 5hfjG-3tmaA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_H_SAMH301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		6 / 12 ASP A 243
ALA A 244
PRO A 262
PHE A 192
GLY A 194
THR A 197
 None
 0.76A 5hfjH-3tmaA:
4.3		 5hfjH-3tmaA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IL1_A_SAMA601_0
(METTL3)		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 ASP A 243
PRO A 262
LEU A 276
PHE A 192
ARG A 221
 None
 1.22A 5il1A-3tmaA:
1.6		 5il1A-3tmaA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		3 / 3 LYS A  34
ASP A  31
ARG A  33
 None
 1.10A 5jwaA-3tmaA:
undetectable
5jwaH-3tmaA:
3.2		 5jwaA-3tmaA:
20.34
5jwaH-3tmaA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MM4_B_TA1B501_1
(TUBULIN BETA CHAIN)		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 10 LEU A 176
ALA A 284
THR A 298
PRO A 309
LEU A 308
 None
 1.28A 5mm4B-3tmaA:
2.8		 5mm4B-3tmaA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A60_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3tma METHYLTRANSFERASE
(Thermus
thermophilus) 		5 / 12 ALA A 173
ALA A 175
GLN A 174
LEU A  53
ARG A 158
 None
 1.02A 6a60D-3tmaA:
undetectable		 6a60D-3tmaA:
15.20