SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tmg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_B_ACAB90_1
(PLASMINOGEN)		 3tmg GLYCINE BETAINE,
L-PROLINE ABC
TRANSPORTER,
GLYCINE/BETAINE/L-PR
OLINE-BINDING
PROTEIN (PROX)
(Borreliella
burgdorferi) 		4 / 7 ASP A 256
ASP A 253
TRP A 196
TYR A 201
 None
 1.44A 1ceaB-3tmgA:
undetectable		 1ceaB-3tmgA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA155_1
(CALMODULIN)		 3tmg GLYCINE BETAINE,
L-PROLINE ABC
TRANSPORTER,
GLYCINE/BETAINE/L-PR
OLINE-BINDING
PROTEIN (PROX)
(Borreliella
burgdorferi) 		4 / 7 GLN A 110
GLU A 217
PHE A  98
ALA A 144
 None
None
None
BET  A 310 ( 4.0A)
 1.37A 1linA-3tmgA:
undetectable		 1linA-3tmgA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 3tmg GLYCINE BETAINE,
L-PROLINE ABC
TRANSPORTER,
GLYCINE/BETAINE/L-PR
OLINE-BINDING
PROTEIN (PROX)
(Borreliella
burgdorferi) 		3 / 3 SER A  81
GLU A  92
ASP A 100
 None
 0.80A 3bwmA-3tmgA:
undetectable		 3bwmA-3tmgA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_1
(COMT PROTEIN)		 3tmg GLYCINE BETAINE,
L-PROLINE ABC
TRANSPORTER,
GLYCINE/BETAINE/L-PR
OLINE-BINDING
PROTEIN (PROX)
(Borreliella
burgdorferi) 		3 / 3 SER A  81
GLU A  92
ASP A 100
 None
 0.82A 3bwyA-3tmgA:
undetectable		 3bwyA-3tmgA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FO7_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 3tmg GLYCINE BETAINE,
L-PROLINE ABC
TRANSPORTER,
GLYCINE/BETAINE/L-PR
OLINE-BINDING
PROTEIN (PROX)
(Borreliella
burgdorferi) 		4 / 5 HIS A 240
ASP A 239
TYR A 236
PRO A 282
 None
 1.37A 3fo7A-3tmgA:
undetectable		 3fo7A-3tmgA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H1X_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 3tmg GLYCINE BETAINE,
L-PROLINE ABC
TRANSPORTER,
GLYCINE/BETAINE/L-PR
OLINE-BINDING
PROTEIN (PROX)
(Borreliella
burgdorferi) 		4 / 5 HIS A 240
ASP A 239
TYR A 236
PRO A 282
 None
 1.39A 3h1xA-3tmgA:
undetectable		 3h1xA-3tmgA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 3tmg GLYCINE BETAINE,
L-PROLINE ABC
TRANSPORTER,
GLYCINE/BETAINE/L-PR
OLINE-BINDING
PROTEIN (PROX)
(Borreliella
burgdorferi) 		5 / 10 LEU A 191
ILE A 203
PRO A 115
SER A 180
SER A 176
 None
 1.41A 3ijxB-3tmgA:
13.3
3ijxD-3tmgA:
13.2		 3ijxB-3tmgA:
23.82
3ijxD-3tmgA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_D_HCZD800_1
(GLUTAMATE RECEPTOR 2)		 3tmg GLYCINE BETAINE,
L-PROLINE ABC
TRANSPORTER,
GLYCINE/BETAINE/L-PR
OLINE-BINDING
PROTEIN (PROX)
(Borreliella
burgdorferi) 		5 / 9 ILE A 203
PRO A 115
SER A 180
SER A 176
LEU A 191
 None
 1.36A 3ijxB-3tmgA:
13.2
3ijxD-3tmgA:
13.2		 3ijxB-3tmgA:
23.82
3ijxD-3tmgA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 3tmg GLYCINE BETAINE,
L-PROLINE ABC
TRANSPORTER,
GLYCINE/BETAINE/L-PR
OLINE-BINDING
PROTEIN (PROX)
(Borreliella
burgdorferi) 		5 / 12 GLY A 145
ALA A 144
PHE A  89
VAL A 149
GLN A 152
 BET  A 310 (-3.7A)
BET  A 310 ( 4.0A)
None
None
None
 1.19A 3nvkF-3tmgA:
undetectable
3nvkJ-3tmgA:
undetectable		 3nvkF-3tmgA:
21.58
3nvkJ-3tmgA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_2
(ADENOSYLHOMOCYSTEINA
SE)		 3tmg GLYCINE BETAINE,
L-PROLINE ABC
TRANSPORTER,
GLYCINE/BETAINE/L-PR
OLINE-BINDING
PROTEIN (PROX)
(Borreliella
burgdorferi) 		3 / 3 GLN A 147
THR A 146
LEU A 174
 None
BET  A 310 (-3.9A)
None
 0.75A 3ondA-3tmgA:
undetectable		 3ondA-3tmgA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_2
(ADENOSYLHOMOCYSTEINA
SE)		 3tmg GLYCINE BETAINE,
L-PROLINE ABC
TRANSPORTER,
GLYCINE/BETAINE/L-PR
OLINE-BINDING
PROTEIN (PROX)
(Borreliella
burgdorferi) 		3 / 3 GLN A 147
THR A 146
LEU A 174
 None
BET  A 310 (-3.9A)
None
 0.76A 3ondB-3tmgA:
undetectable		 3ondB-3tmgA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)		 3tmg GLYCINE BETAINE,
L-PROLINE ABC
TRANSPORTER,
GLYCINE/BETAINE/L-PR
OLINE-BINDING
PROTEIN (PROX)
(Borreliella
burgdorferi) 		5 / 12 GLY A  77
ALA A 234
LEU A 222
PHE A  98
LEU A 227
 None
 1.07A 3p2kA-3tmgA:
undetectable		 3p2kA-3tmgA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)		 3tmg GLYCINE BETAINE,
L-PROLINE ABC
TRANSPORTER,
GLYCINE/BETAINE/L-PR
OLINE-BINDING
PROTEIN (PROX)
(Borreliella
burgdorferi) 		5 / 12 GLY A  77
ALA A 234
LEU A 222
PHE A  98
LEU A 227
 None
 1.02A 3p2kC-3tmgA:
undetectable		 3p2kC-3tmgA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_0
(MNMC2)		 3tmg GLYCINE BETAINE,
L-PROLINE ABC
TRANSPORTER,
GLYCINE/BETAINE/L-PR
OLINE-BINDING
PROTEIN (PROX)
(Borreliella
burgdorferi) 		5 / 12 GLY A  77
GLY A  31
GLU A  57
ALA A 234
LEU A 227
 None
 1.13A 3vywA-3tmgA:
undetectable		 3vywA-3tmgA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT7_A_TOPA302_1
(RV2671)		 3tmg GLYCINE BETAINE,
L-PROLINE ABC
TRANSPORTER,
GLYCINE/BETAINE/L-PR
OLINE-BINDING
PROTEIN (PROX)
(Borreliella
burgdorferi) 		5 / 11 ILE A  30
GLY A  77
PHE A  59
GLU A  57
THR A  42
 None
 1.27A 4xt7A-3tmgA:
undetectable		 4xt7A-3tmgA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT8_A_TMQA302_1
(RV2671)		 3tmg GLYCINE BETAINE,
L-PROLINE ABC
TRANSPORTER,
GLYCINE/BETAINE/L-PR
OLINE-BINDING
PROTEIN (PROX)
(Borreliella
burgdorferi) 		5 / 12 ILE A  30
GLY A  77
PHE A  59
GLU A  57
THR A  42
 None
 1.26A 4xt8A-3tmgA:
undetectable		 4xt8A-3tmgA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 3tmg GLYCINE BETAINE,
L-PROLINE ABC
TRANSPORTER,
GLYCINE/BETAINE/L-PR
OLINE-BINDING
PROTEIN (PROX)
(Borreliella
burgdorferi) 		3 / 3 SER A  81
GLU A  92
ASP A 100
 None
 0.76A 4xudA-3tmgA:
undetectable		 4xudA-3tmgA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 3tmg GLYCINE BETAINE,
L-PROLINE ABC
TRANSPORTER,
GLYCINE/BETAINE/L-PR
OLINE-BINDING
PROTEIN (PROX)
(Borreliella
burgdorferi) 		5 / 12 LEU A  45
PHE A 241
GLU A  38
VAL A  79
GLY A 260
 None
None
BET  A 310 (-4.1A)
None
None
 1.37A 5f9zB-3tmgA:
3.1		 5f9zB-3tmgA:
20.74