SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tmp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P62_B_GEOB302_1
(DEOXYCYTIDINE KINASE)		 3tmp OTU
DOMAIN-CONTAINING
PROTEIN 5
(Homo
sapiens) 		5 / 11 GLU A 264
VAL A 262
MET A 252
ARG A 272
GLU A 284
 None
None
None
SEP  A 177 ( 3.1A)
None
 1.21A 1p62B-3tmpA:
undetectable		 1p62B-3tmpA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VPP_A_GEOA1210_1
(DEOXYNUCLEOSIDE
KINASE)		 3tmp OTU
DOMAIN-CONTAINING
PROTEIN 5
(Homo
sapiens) 		5 / 12 GLU A 264
VAL A 262
MET A 252
ARG A 272
GLU A 284
 None
None
None
SEP  A 177 ( 3.1A)
None
 1.30A 2vppA-3tmpA:
undetectable		 2vppA-3tmpA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VPP_B_GEOB1207_1
(DEOXYNUCLEOSIDE
KINASE)		 3tmp OTU
DOMAIN-CONTAINING
PROTEIN 5
(Homo
sapiens) 		5 / 12 GLU A 264
VAL A 262
MET A 252
ARG A 272
GLU A 284
 None
None
None
SEP  A 177 ( 3.1A)
None
 1.34A 2vppB-3tmpA:
undetectable		 2vppB-3tmpA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 3tmp OTU
DOMAIN-CONTAINING
PROTEIN 5
(Homo
sapiens) 		4 / 5 TYR A 269
LYS A 178
TYR A 181
GLU A 284
 SEP  A 177 ( 4.9A)
SEP  A 177 ( 2.7A)
SEP  A 177 ( 4.1A)
None
 1.34A 4x61A-3tmpA:
undetectable		 4x61A-3tmpA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OAJ_E_TKTE601_1
()		 3tmp OTU
DOMAIN-CONTAINING
PROTEIN 5
(Homo
sapiens) 		4 / 8 GLU A 264
CYH A 278
TYR A 269
TYR A 181
 None
SEP  A 177 ( 4.8A)
SEP  A 177 ( 4.9A)
SEP  A 177 ( 4.1A)
 1.27A 5oajD-3tmpA:
undetectable
5oajE-3tmpA:
undetectable		 5oajD-3tmpA:
19.54
5oajE-3tmpA:
19.54