SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tmq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 3tmq 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE 2
(Burkholderia
pseudomallei) 		4 / 4 LEU A 146
VAL A 150
CYH A 153
ALA A 127
 None
 1.20A 1mz9E-3tmqA:
undetectable		 1mz9E-3tmqA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 3tmq 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE 2
(Burkholderia
pseudomallei) 		4 / 6 LEU A  26
VAL A 133
VAL A 103
ILE A  91
 None
 1.02A 2hyyA-3tmqA:
undetectable		 2hyyA-3tmqA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQZ_A_LQZA586_1
(SERUM ALBUMIN)		 3tmq 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE 2
(Burkholderia
pseudomallei) 		4 / 6 ARG A 166
ASP A 197
LYS A 136
LYS A  53
 NO3  A 284 (-3.9A)
None
NO3  A 284 ( 2.5A)
NO3  A 283 (-2.8A)
 1.40A 3jqzA-3tmqA:
undetectable		 3jqzA-3tmqA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSK_B_ACTB901_0
(PYRANOSE 2-OXIDASE)		 3tmq 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE 2
(Burkholderia
pseudomallei) 		4 / 6 SER A  55
GLN A 111
PHE A 235
HIS A 200
 NO3  A 283 (-3.0A)
NO3  A 283 (-3.6A)
NO3  A 283 (-4.0A)
A5P  A 282 ( 4.0A)
 1.34A 3lskB-3tmqA:
undetectable		 3lskB-3tmqA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSK_D_ACTD901_0
(PYRANOSE 2-OXIDASE)		 3tmq 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE 2
(Burkholderia
pseudomallei) 		4 / 6 SER A  55
GLN A 111
PHE A 235
HIS A 200
 NO3  A 283 (-3.0A)
NO3  A 283 (-3.6A)
NO3  A 283 (-4.0A)
A5P  A 282 ( 4.0A)
 1.33A 3lskD-3tmqA:
undetectable		 3lskD-3tmqA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_C_DXCC92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3tmq 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE 2
(Burkholderia
pseudomallei) 		4 / 4 VAL A  82
PHE A  52
PHE A  20
VAL A 109
 None
 1.47A 3rv5C-3tmqA:
undetectable
3rv5D-3tmqA:
undetectable		 3rv5C-3tmqA:
15.64
3rv5D-3tmqA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ1_X_DXCX75_0
(CYTOCHROME C7)		 3tmq 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE 2
(Burkholderia
pseudomallei) 		4 / 6 ILE A  23
LEU A  26
LYS A  83
PHE A  79
 None
 0.98A 3sj1X-3tmqA:
undetectable		 3sj1X-3tmqA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VN2_A_TLSA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3tmq 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE 2
(Burkholderia
pseudomallei) 		5 / 12 PHE A 196
SER A 168
LEU A 163
PHE A 182
MET A 185
 None
 1.37A 3vn2A-3tmqA:
undetectable		 3vn2A-3tmqA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HBF_A_DXCA75_0
(PPCA)		 3tmq 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE 2
(Burkholderia
pseudomallei) 		4 / 7 ILE A  23
LEU A  26
LYS A  83
PHE A  79
 None
 1.03A 4hbfA-3tmqA:
undetectable		 4hbfA-3tmqA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 3tmq 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE 2
(Burkholderia
pseudomallei) 		5 / 11 VAL A  94
THR A  92
VAL A 124
ALA A 107
VAL A 135
 None
 1.22A 6dryA-3tmqA:
undetectable		 6dryA-3tmqA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 3tmq 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE 2
(Burkholderia
pseudomallei) 		4 / 5 ARG A  61
ARG A  68
GLY A  69
ASP A  57
 A5P  A 282 (-3.9A)
None
None
None
 1.33A 6dwjB-3tmqA:
undetectable
6dwjD-3tmqA:
undetectable		 6dwjB-3tmqA:
19.93
6dwjD-3tmqA:
19.93