SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tnd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AY0_A_ADNA401_1 (UNCHARACTERIZED PROTEIN MJ0883)	3tnd	TRNA(FMET)-SPECIFIC ENDONUCLEASE VAPC (Shigella flexneri)	5 / 10	ASP A 7 ILE A 10 ASN A 9 LEU A 43 PHE A 63	None None NA B 82 ( 4.4A) None None	1.37A	3ay0A-3tndA: undetectable	3ay0A-3tndA: 16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PGF_A_ADNA502_2 (ADENOSYLHOMOCYSTEINA SE)	3tnd	ANTITOXIN VAPB (Shigella flexneri)	4 / 6	THR B 46 GLU B 30 THR B 41 THR B 37	None	1.07A	4pgfA-3tndB: undetectable	4pgfA-3tndB: 11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XP9_C_1WEC706_1 (TRANSPORTER)	3tnd	ANTITOXIN VAPB TRNA(FMET)-SPECIFIC ENDONUCLEASE VAPC (Shigella flexneri)	4 / 4	PHE B 60 ASP B 59 GLY A 46 SER B 57	None	1.46A	4xp9C-3tndB: undetectable	4xp9C-3tndB: 8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Z84_W_CHDW101_0 (CYTOCHROME C OXIDASE SUBUNIT 1 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	3tnd	TRNA(FMET)-SPECIFIC ENDONUCLEASE VAPC (Shigella flexneri)	4 / 5	ILE A 67 PHE A 63 ARG A 25 THR A 114	None	1.13A	5z84N-3tndA: undetectable 5z84W-3tndA: undetectable	5z84N-3tndA: 12.12 5z84W-3tndA: 14.62

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3AY0_A_ADNA401_1","UNCHARACTERIZED PROTEIN MJ0883","3tnd","TRNA(FMET)-SPECIFIC ENDONUCLEASE VAPC","Shigella flexneri",5,"ASP A   7;ILE A  10;ASN A   9;LEU A  43;PHE A  63","None;None; NA B  82 ( 4.4A);None;None","1.37A","3ay0A-3tndA:undetectable","3ay0A-3tndA:16.52"],["4PGF_A_ADNA502_2","ADENOSYLHOMOCYSTEINASE","3tnd","ANTITOXIN VAPB","Shigella flexneri",4,"THR B  46;GLU B  30;THR B  41;THR B  37","None","1.07A","4pgfA-3tndB:undetectable","4pgfA-3tndB:11.76"],["4XP9_C_1WEC706_1","TRANSPORTER","3tnd","ANTITOXIN VAPB;TRNA(FMET)-SPECIFIC ENDONUCLEASE VAPC","Shigella flexneri",4,"PHE B  60;ASP B  59;GLY A  46;SER B  57","None","1.46A","4xp9C-3tndB:undetectable","4xp9C-3tndB:8.76"],["5Z84_W_CHDW101_0","CYTOCHROME C OXIDASE SUBUNIT 1;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","3tnd","TRNA(FMET)-SPECIFIC ENDONUCLEASE VAPC","Shigella flexneri",4,"ILE A  67;PHE A  63;ARG A  25;THR A 114","None","1.13A","5z84N-3tndA:undetectable;5z84W-3tndA:undetectable","5z84N-3tndA:12.12;5z84W-3tndA:14.62"]]