SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tnf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3tnf LIDA
(Legionella
pneumophila) 		3 / 3 VAL B 447
LYS B 452
HIS B 469
 None
 0.86A 3elzA-3tnfB:
undetectable		 3elzA-3tnfB:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_C_LEIC16_0
(COIL SER L16D-PEN)		 3tnf LIDA
(Legionella
pneumophila) 		4 / 6 LEU B 564
LYS B 218
LEU B 222
GLU B 223
 None
 0.86A 3h5gB-3tnfB:
undetectable
3h5gC-3tnfB:
undetectable		 3h5gB-3tnfB:
7.16
3h5gC-3tnfB:
7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_B_PNNB5002_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3tnf LIDA
(Legionella
pneumophila) 		4 / 5 ASN B 368
ALA B 370
ALA B 371
LYS B 377
 None
 1.29A 3kp2B-3tnfB:
1.0		 3kp2B-3tnfB:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3tnf LIDA
(Legionella
pneumophila) 		5 / 12 ILE B 303
ALA B 271
LEU B 310
SER B 399
ILE B 395
 None
 1.29A 4gh8B-3tnfB:
undetectable		 4gh8B-3tnfB:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QD3_A_5AEA201_1
(PEPTIDYL-TRNA
HYDROLASE)		 3tnf LIDA
(Legionella
pneumophila) 		5 / 9 LEU B 247
GLY B 433
ASN B 435
VAL B 542
VAL B 538
 None
 0.98A 4qd3A-3tnfB:
undetectable		 4qd3A-3tnfB:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3tnf LIDA
(Legionella
pneumophila) 		4 / 8 PHE B 272
SER B 276
ALA B 305
PHE B 250
 None
 1.03A 4rkuA-3tnfB:
2.4
4rkuJ-3tnfB:
undetectable		 4rkuA-3tnfB:
19.37
4rkuJ-3tnfB:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3tnf LIDA
(Legionella
pneumophila) 		4 / 8 PHE B 272
SER B 276
ALA B 308
PHE B 250
 None
 1.04A 4rkuA-3tnfB:
2.4
4rkuJ-3tnfB:
undetectable		 4rkuA-3tnfB:
19.37
4rkuJ-3tnfB:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3tnf LIDA
(Legionella
pneumophila) 		4 / 5 ALA B 305
ARG B 449
HIS B 396
GLU B 392
 None
 1.30A 5a06C-3tnfB:
undetectable
5a06D-3tnfB:
undetectable		 5a06C-3tnfB:
20.39
5a06D-3tnfB:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_G_SAMG301_1
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 3tnf LIDA
(Legionella
pneumophila) 		4 / 4 ASP B 336
HIS B 317
SER B 261
GLU B 259
 None
 1.44A 5hfjG-3tnfB:
0.0		 5hfjG-3tnfB:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GQI_A_ACTA604_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 3tnf LIDA
(Legionella
pneumophila) 		4 / 6 TRP B 510
ILE B 513
TYR B 502
GLU B 508
 None
 1.09A 6gqiA-3tnfB:
undetectable		 6gqiA-3tnfB:
20.58