SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tni'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3tni CYCLIN-T1
(Homo
sapiens) 		4 / 6 ALA B  91
GLU B  95
LEU B  57
LEU B 182
 None
 0.98A 1mt1D-3tniB:
undetectable
1mt1E-3tniB:
undetectable		 1mt1D-3tniB:
16.60
1mt1E-3tniB:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 3tni CYCLIN-T1
(Homo
sapiens) 		4 / 6 LEU B 241
ASN B  43
GLN B  56
PHE B 187
 None
 1.24A 2jn3A-3tniB:
undetectable		 2jn3A-3tniB:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3tni CYCLIN-T1
(Homo
sapiens) 		4 / 7 TRP B 221
SER B 208
ILE B 212
SER B 174
 None
 1.28A 2xz5A-3tniB:
undetectable
2xz5B-3tniB:
undetectable		 2xz5A-3tniB:
21.07
2xz5B-3tniB:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3tni CYCLIN-T1
(Homo
sapiens) 		3 / 3 ASP B  32
LEU B  35
GLN B 190
 None
 0.73A 3g4lA-3tniB:
undetectable		 3g4lA-3tniB:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3tni CYCLIN-T1
(Homo
sapiens) 		5 / 12 LEU B 241
ILE B 255
SER B 188
HIS B 154
VAL B  64
 None
 1.26A 3w1wA-3tniB:
undetectable		 3w1wA-3tniB:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 3tni CYCLIN-T1
(Homo
sapiens) 		3 / 3 ILE B 105
MET B  48
ARG B  51
 None
 0.83A 4lnwA-3tniB:
undetectable		 4lnwA-3tniB:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_2
(THYROID HORMONE
RECEPTOR ALPHA)		 3tni CYCLIN-T1
(Homo
sapiens) 		3 / 3 ILE B 105
MET B  48
ARG B  51
 None
 0.83A 4lnxA-3tniB:
undetectable		 4lnxA-3tniB:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUH_A_ACTA610_0
(SERUM ALBUMIN)		 3tni CYCLIN-T1
(Homo
sapiens) 		3 / 3 VAL B  54
SER B  55
THR B  58
 None
 0.45A 4luhA-3tniB:
1.5		 4luhA-3tniB:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVD_A_SAMA502_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 3tni CYCLIN-T1
(Homo
sapiens) 		5 / 12 ILE B 150
PRO B 153
ALA B 178
VAL B  64
HIS B  67
 None
 1.13A 4rvdA-3tniB:
undetectable		 4rvdA-3tniB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 3tni CYCLIN-T1
(Homo
sapiens) 		5 / 12 ILE B 150
PRO B 153
ALA B 178
VAL B  64
HIS B  67
 None
 1.12A 4rvgA-3tniB:
undetectable		 4rvgA-3tniB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 3tni CYCLIN-T1
(Homo
sapiens) 		5 / 12 LEU B 184
HIS B 154
ASN B  60
LEU B  88
ILE B  59
 None
 1.43A 5dv4A-3tniB:
undetectable		 5dv4A-3tniB:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JM4_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 3tni CYCLIN-T1
(Homo
sapiens) 		4 / 5 PHE B 176
ILE B 255
MET B 177
ARG B 251
 None
 1.04A 5jm4A-3tniB:
2.4		 5jm4A-3tniB:
22.01