SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tnl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3tnl SHIKIMATE
DEHYDROGENASE
(Listeria
monocytogenes) 		4 / 5 PRO A  29
ILE A  19
GLY A  17
TYR A  45
 None
 1.12A 2jkjD-3tnlA:
undetectable		 2jkjD-3tnlA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 3tnl SHIKIMATE
DEHYDROGENASE
(Listeria
monocytogenes) 		4 / 5 PRO A  29
ILE A  19
GLY A  17
TYR A  45
 None
 1.12A 2jkjF-3tnlA:
undetectable		 2jkjF-3tnlA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 3tnl SHIKIMATE
DEHYDROGENASE
(Listeria
monocytogenes) 		3 / 3 GLY A 109
TRP A  70
VAL A  72
 None
 0.74A 3n62B-3tnlA:
undetectable		 3n62B-3tnlA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N65_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 3tnl SHIKIMATE
DEHYDROGENASE
(Listeria
monocytogenes) 		3 / 3 GLY A 109
TRP A  70
VAL A  72
 None
 0.71A 3n65B-3tnlA:
undetectable		 3n65B-3tnlA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 3tnl SHIKIMATE
DEHYDROGENASE
(Listeria
monocytogenes) 		3 / 3 GLY A 109
TRP A  70
VAL A  72
 None
 0.73A 3n66B-3tnlA:
undetectable		 3n66B-3tnlA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WQW_A_GCSA502_1
(CHITINASE)		 3tnl SHIKIMATE
DEHYDROGENASE
(Listeria
monocytogenes) 		4 / 5 GLY A 116
TRP A 267
ALA A 120
PHE A 291
 None
 0.92A 3wqwA-3tnlA:
undetectable		 3wqwA-3tnlA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_A_CCSA109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 3tnl SHIKIMATE
DEHYDROGENASE
(Listeria
monocytogenes) 		4 / 8 TYR A  45
ASN A  71
VAL A 101
ILE A 275
 None
SKM  A 293 (-3.4A)
None
None
 0.93A 4eyzA-3tnlA:
undetectable		 4eyzA-3tnlA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_B_CCSB109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 3tnl SHIKIMATE
DEHYDROGENASE
(Listeria
monocytogenes) 		4 / 8 TYR A  45
ASN A  71
VAL A 101
ILE A 275
 None
SKM  A 293 (-3.4A)
None
None
 0.94A 4eyzB-3tnlA:
undetectable		 4eyzB-3tnlA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_2
(ASPARTYL PROTEASE)		 3tnl SHIKIMATE
DEHYDROGENASE
(Listeria
monocytogenes) 		5 / 12 LEU A 187
ILE A 135
ILE A 145
GLY A 140
ILE A 159
 None
None
None
NAD  A 292 (-3.7A)
None
 0.83A 4q1xB-3tnlA:
undetectable		 4q1xB-3tnlA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_2
(ASPARTYL PROTEASE)		 3tnl SHIKIMATE
DEHYDROGENASE
(Listeria
monocytogenes) 		5 / 12 LEU A 187
ILE A 135
ILE A 145
GLY A 140
ILE A 159
 None
None
None
NAD  A 292 (-3.7A)
None
 0.82A 4q1yB-3tnlA:
undetectable		 4q1yB-3tnlA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3tnl SHIKIMATE
DEHYDROGENASE
(Listeria
monocytogenes) 		5 / 11 THR A  78
THR A  99
GLY A 140
ALA A 144
THR A 143
 None
None
NAD  A 292 (-3.7A)
None
None
 1.47A 4qw0V-3tnlA:
undetectable
4qw0b-3tnlA:
undetectable		 4qw0V-3tnlA:
21.82
4qw0b-3tnlA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_A_STRA601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 3tnl SHIKIMATE
DEHYDROGENASE
(Listeria
monocytogenes) 		4 / 6 ALA A 209
ILE A 111
GLY A 140
ILE A 135
 None
None
NAD  A 292 (-3.7A)
None
 0.76A 4r21A-3tnlA:
undetectable		 4r21A-3tnlA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XYZ_A_ACTA103_0
(POLYUBIQUITIN-C)		 3tnl SHIKIMATE
DEHYDROGENASE
(Listeria
monocytogenes) 		4 / 4 LEU A  87
ILE A  80
HIS A  81
VAL A  97
 None
 1.10A 4xyzA-3tnlA:
undetectable		 4xyzA-3tnlA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 3tnl SHIKIMATE
DEHYDROGENASE
(Listeria
monocytogenes) 		5 / 11 THR A  78
THR A  99
GLY A 140
ALA A 144
THR A 143
 None
None
NAD  A 292 (-3.7A)
None
None
 1.49A 5d0xH-3tnlA:
undetectable
5d0xN-3tnlA:
undetectable		 5d0xH-3tnlA:
21.82
5d0xN-3tnlA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)		 3tnl SHIKIMATE
DEHYDROGENASE
(Listeria
monocytogenes) 		5 / 12 GLY A 269
GLN A 268
LEU A  15
PHE A  48
PHE A  36
 None
SKM  A 293 (-3.3A)
None
None
None
 1.22A 5fsaB-3tnlA:
undetectable		 5fsaB-3tnlA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3tnl SHIKIMATE
DEHYDROGENASE
(Listeria
monocytogenes) 		5 / 12 ILE A  80
PHE A  62
GLY A  69
GLY A 109
LEU A  87
 None
 0.93A 5i71A-3tnlA:
undetectable		 5i71A-3tnlA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3tnl SHIKIMATE
DEHYDROGENASE
(Listeria
monocytogenes) 		5 / 12 ILE A  80
PHE A  62
GLY A  69
GLY A 109
LEU A  87
 None
 0.86A 5i73A-3tnlA:
undetectable		 5i73A-3tnlA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA503_1
(-)		 3tnl SHIKIMATE
DEHYDROGENASE
(Listeria
monocytogenes) 		5 / 9 LEU A 151
VAL A  94
LEU A  93
ILE A 157
MET A 118
 None
 1.30A 5og9A-3tnlA:
undetectable		 5og9A-3tnlA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Q1S_A_AWYA1103_0
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 3tnl SHIKIMATE
DEHYDROGENASE
(Listeria
monocytogenes) 		4 / 6 LYS A  82
VAL A  58
LYS A  56
ILE A  19
 None
 1.00A 5q1sA-3tnlA:
undetectable		 5q1sA-3tnlA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3tnl SHIKIMATE
DEHYDROGENASE
(Listeria
monocytogenes) 		3 / 3 GLY A 109
TRP A  70
VAL A  72
 None
 0.73A 5vuoB-3tnlA:
undetectable		 5vuoB-3tnlA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 3tnl SHIKIMATE
DEHYDROGENASE
(Listeria
monocytogenes) 		5 / 12 CYH A 146
ALA A 142
ASN A 208
ILE A 157
ILE A 205
 None
 1.01A 5xiwB-3tnlA:
undetectable		 5xiwB-3tnlA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJ1_T_6ELT501_0
(PROTEIN CEREBLON)		 3tnl SHIKIMATE
DEHYDROGENASE
(Listeria
monocytogenes) 		4 / 8 HIS A 110
THR A 108
HIS A 278
PHE A  36
 None
 1.35A 5yj1k-3tnlA:
undetectable
5yj1t-3tnlA:
undetectable		 5yj1k-3tnlA:
18.18
5yj1t-3tnlA:
18.18