SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tnx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3tnx PAPAIN
(Carica
papaya) 		3 / 3 GLU A 157
TYR A 195
PHE A 135
 None
 0.87A 1eqbB-3tnxA:
undetectable		 1eqbB-3tnxA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3tnx PAPAIN
(Carica
papaya) 		3 / 3 GLU A 157
TYR A 195
PHE A 135
 None
 0.86A 1eqbA-3tnxA:
undetectable		 1eqbA-3tnxA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3tnx PAPAIN
(Carica
papaya) 		3 / 3 GLU A 157
TYR A 195
PHE A 135
 None
 0.87A 1eqbD-3tnxA:
undetectable		 1eqbD-3tnxA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3tnx PAPAIN
(Carica
papaya) 		3 / 3 GLU A 157
TYR A 195
PHE A 135
 None
 0.87A 1eqbC-3tnxA:
undetectable		 1eqbC-3tnxA:
21.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 3tnx PAPAIN
(Carica
papaya) 		7 / 10 GLN A 126
GLY A 130
SER A 131
PHE A 135
SER A 136
ALA A 267
GLY A 172
 None
 1.27A 1stfE-3tnxA:
37.3
1stfI-3tnxA:
undetectable		 1stfE-3tnxA:
96.70
1stfI-3tnxA:
14.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 3tnx PAPAIN
(Carica
papaya) 		8 / 10 GLN A 126
GLY A 130
SER A 131
PHE A 135
SER A 136
HIS A 266
ALA A 267
GLY A  84
 None
 0.69A 1stfE-3tnxA:
37.3
1stfI-3tnxA:
undetectable		 1stfE-3tnxA:
96.70
1stfI-3tnxA:
14.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 3tnx PAPAIN
(Carica
papaya) 		8 / 10 GLN A 126
GLY A 130
SER A 131
TRP A 133
PHE A 135
SER A 136
HIS A 266
ALA A 267
 None
 0.29A 1stfE-3tnxA:
37.3
1stfI-3tnxA:
undetectable		 1stfE-3tnxA:
96.70
1stfI-3tnxA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_B_SAMB3141_0
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 3tnx PAPAIN
(Carica
papaya) 		5 / 12 GLY A 173
GLY A 172
GLY A  84
ASP A 164
PHE A 314
 None
 1.19A 1wg8B-3tnxA:
undetectable		 1wg8B-3tnxA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		 3tnx PAPAIN
(Carica
papaya) 		4 / 4 LEU A 309
PRO A 316
ILE A 232
LEU A 228
 None
 1.09A 1ya4B-3tnxA:
undetectable		 1ya4B-3tnxA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)		 3tnx PAPAIN
(Carica
papaya) 		5 / 12 GLN A 249
ALA A  71
ASP A 247
GLY A 253
LEU A 250
 None
 1.38A 2nv4B-3tnxA:
undetectable		 2nv4B-3tnxA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_A_BEZA1222_0
(PEROXIREDOXIN 6)		 3tnx PAPAIN
(Carica
papaya) 		4 / 7 THR A 121
PRO A 122
VAL A 123
GLU A 157
 None
 1.05A 2v2gA-3tnxA:
undetectable
2v2gB-3tnxA:
undetectable		 2v2gA-3tnxA:
23.06
2v2gB-3tnxA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_B_BEZB1220_0
(PEROXIREDOXIN 6)		 3tnx PAPAIN
(Carica
papaya) 		4 / 7 THR A 121
PRO A 122
VAL A 123
GLU A 157
 None
 1.04A 2v2gA-3tnxA:
undetectable
2v2gB-3tnxA:
undetectable		 2v2gA-3tnxA:
23.06
2v2gB-3tnxA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_C_BEZC1222_0
(PEROXIREDOXIN 6)		 3tnx PAPAIN
(Carica
papaya) 		4 / 7 THR A 121
PRO A 122
VAL A 123
GLU A 157
 None
 1.06A 2v2gC-3tnxA:
undetectable
2v2gD-3tnxA:
undetectable		 2v2gC-3tnxA:
23.06
2v2gD-3tnxA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_D_BEZD1221_0
(PEROXIREDOXIN 6)		 3tnx PAPAIN
(Carica
papaya) 		4 / 7 THR A 121
PRO A 122
VAL A 123
GLU A 157
 None
 1.06A 2v2gC-3tnxA:
undetectable
2v2gD-3tnxA:
undetectable		 2v2gC-3tnxA:
23.06
2v2gD-3tnxA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_A_BEZA1222_0
(PEROXIREDOXIN 6)		 3tnx PAPAIN
(Carica
papaya) 		4 / 8 THR A 121
PRO A 122
VAL A 123
GLU A 157
 None
 1.00A 2v32A-3tnxA:
undetectable
2v32B-3tnxA:
undetectable		 2v32A-3tnxA:
23.06
2v32B-3tnxA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_E_BEZE1222_0
(PEROXIREDOXIN 6.)		 3tnx PAPAIN
(Carica
papaya) 		4 / 7 THR A 121
PRO A 122
VAL A 123
GLU A 157
 None
 1.04A 2v41E-3tnxA:
undetectable
2v41F-3tnxA:
undetectable		 2v41E-3tnxA:
23.06
2v41F-3tnxA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_F_BEZF1222_0
(PEROXIREDOXIN 6.)		 3tnx PAPAIN
(Carica
papaya) 		4 / 7 THR A 121
PRO A 122
VAL A 123
GLU A 157
 None
 1.09A 2v41E-3tnxA:
undetectable
2v41F-3tnxA:
undetectable		 2v41E-3tnxA:
23.06
2v41F-3tnxA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1303_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3tnx PAPAIN
(Carica
papaya) 		4 / 7 SER A  62
ILE A 255
PRO A 259
GLY A 258
 None
 0.99A 2y7kA-3tnxA:
undetectable		 2y7kA-3tnxA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 3tnx PAPAIN
(Carica
papaya) 		4 / 7 GLN A 126
GLY A 130
HIS A 266
TRP A 284
 None
 0.47A 3ai8A-3tnxA:
25.3		 3ai8A-3tnxA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_2
(HIV-1 PROTEASE)		 3tnx PAPAIN
(Carica
papaya) 		3 / 3 ARG A 218
VAL A 182
THR A 214
 None
 0.85A 3cyxA-3tnxA:
undetectable		 3cyxA-3tnxA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQT_C_C5EC301_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3tnx PAPAIN
(Carica
papaya) 		4 / 8 VAL A 257
TYR A 251
TYR A  63
ILE A 296
 None
 1.31A 4bqtC-3tnxA:
undetectable
4bqtD-3tnxA:
undetectable		 4bqtC-3tnxA:
20.44
4bqtD-3tnxA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3tnx PAPAIN
(Carica
papaya) 		3 / 3 PHE A 135
VAL A 271
ILE A 280
 None
 0.60A 4emaA-3tnxA:
undetectable		 4emaA-3tnxA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_2
(PROTEASE E35D-DRV)		 3tnx PAPAIN
(Carica
papaya) 		4 / 7 ASN A 224
GLY A 226
ALA A 227
GLY A 104
 None
 0.44A 5kqyB-3tnxA:
undetectable		 5kqyB-3tnxA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_2
(PROTEASE PR5-DRV)		 3tnx PAPAIN
(Carica
papaya) 		4 / 8 ASN A 224
GLY A 226
ALA A 227
GLY A 104
 None
 0.52A 5kr1B-3tnxA:
undetectable		 5kr1B-3tnxA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 3tnx PAPAIN
(Carica
papaya) 		4 / 6 GLY A 308
THR A 311
SER A 238
SER A 313
 None
 1.05A 6jogA-3tnxA:
undetectable		 6jogA-3tnxA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MD4_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3tnx PAPAIN
(Carica
papaya) 		5 / 12 PHE A 314
GLN A 219
LEU A 309
ILE A 232
TYR A  90
 None
 1.36A 6md4A-3tnxA:
undetectable		 6md4A-3tnxA:
11.73