SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3to4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1N_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 3to4 NKT VBETA2 (MOUSE
VARIABLE DOMAIN,
HUMAN CONSTANT
DOMAIN)
(Homo
sapiens;
Mus
musculus) 		5 / 11 THR D 115
LEU D  12
GLY D 219
VAL D 158
ASP D 156
 None
 1.27A 2a1nA-3to4D:
undetectable		 2a1nA-3to4D:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 3to4 NKT VBETA2 (MOUSE
VARIABLE DOMAIN,
HUMAN CONSTANT
DOMAIN)
(Homo
sapiens;
Mus
musculus) 		5 / 9 THR D 115
LEU D  12
GLY D 219
VAL D 158
ASP D 156
 None
 1.24A 2a1oB-3to4D:
undetectable		 2a1oB-3to4D:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 3to4 NKT VBETA2 (MOUSE
VARIABLE DOMAIN,
HUMAN CONSTANT
DOMAIN)
(Homo
sapiens;
Mus
musculus) 		5 / 10 THR D 115
LEU D  12
GLY D 219
VAL D 158
ASP D 156
 None
 1.27A 2cp4A-3to4D:
undetectable		 2cp4A-3to4D:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_B_9PLB501_1
(CYTOCHROME P450 2E1)		 3to4 NKT VBETA2 (MOUSE
VARIABLE DOMAIN,
HUMAN CONSTANT
DOMAIN)
(Homo
sapiens;
Mus
musculus) 		4 / 6 LEU D  61
PHE D  48
ALA D  69
LEU D  90
 None
 1.00A 3t3zB-3to4D:
undetectable		 3t3zB-3to4D:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_2
(PROTEASE E35D-DRV)		 3to4 NKT VBETA2 (MOUSE
VARIABLE DOMAIN,
HUMAN CONSTANT
DOMAIN)
(Homo
sapiens;
Mus
musculus) 		4 / 7 GLY D  63
ALA D  64
ASP D  65
GLY D  16
 None
 0.63A 5kqyB-3to4D:
undetectable		 5kqyB-3to4D:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_2
(PROTEASE PR5-DRV)		 3to4 NKT VBETA2 (MOUSE
VARIABLE DOMAIN,
HUMAN CONSTANT
DOMAIN)
(Homo
sapiens;
Mus
musculus) 		4 / 8 GLY D  63
ALA D  64
ASP D  65
GLY D  16
 None
 0.64A 5kr1B-3to4D:
undetectable		 5kr1B-3to4D:
16.18