SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3toj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_0
(HYPOTHETICAL PROTEIN
PH0226)		 3toj SET1/ASH2 HISTONE
METHYLTRANSFERASE
COMPLEX SUBUNIT ASH2
(Homo
sapiens) 		5 / 12 TYR A 364
GLY A 345
SER A 473
ALA A 318
ILE A 396
 None
 1.04A 1ve3A-3tojA:
undetectable		 1ve3A-3tojA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_B_SAMB301_0
(HYPOTHETICAL PROTEIN
PH0226)		 3toj SET1/ASH2 HISTONE
METHYLTRANSFERASE
COMPLEX SUBUNIT ASH2
(Homo
sapiens) 		5 / 12 TYR A 364
GLY A 345
SER A 473
ALA A 318
ILE A 396
 None
 1.05A 1ve3B-3tojA:
undetectable		 1ve3B-3tojA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 3toj SET1/ASH2 HISTONE
METHYLTRANSFERASE
COMPLEX SUBUNIT ASH2
(Homo
sapiens) 		4 / 8 ASP A 360
SER A 363
ALA A 355
TYR A 359
 None
 1.18A 4lv9A-3tojA:
undetectable
4lv9B-3tojA:
undetectable		 4lv9A-3tojA:
17.96
4lv9B-3tojA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA602_1
(SERUM ALBUMIN)		 3toj SET1/ASH2 HISTONE
METHYLTRANSFERASE
COMPLEX SUBUNIT ASH2
(Homo
sapiens) 		4 / 6 ARG A 317
ALA A 471
ASP A 293
LEU A 357
 None
 0.91A 4ot2A-3tojA:
undetectable		 4ot2A-3tojA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_A_SALA301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 3toj SET1/ASH2 HISTONE
METHYLTRANSFERASE
COMPLEX SUBUNIT ASH2
(Homo
sapiens) 		4 / 5 ALA A 318
VAL A 316
PHE A 484
ILE A 300
 None
 0.72A 5of1A-3tojA:
1.9		 5of1A-3tojA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_B_SALB301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 3toj SET1/ASH2 HISTONE
METHYLTRANSFERASE
COMPLEX SUBUNIT ASH2
(Homo
sapiens) 		4 / 5 ALA A 318
VAL A 316
PHE A 484
ILE A 300
 None
 0.77A 5of1B-3tojA:
1.5		 5of1B-3tojA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3toj SET1/ASH2 HISTONE
METHYLTRANSFERASE
COMPLEX SUBUNIT ASH2
(Homo
sapiens) 		4 / 6 LEU A 298
ARG A 294
VAL A 307
LEU A 289
 None
 0.95A 5x7zA-3tojA:
undetectable		 5x7zA-3tojA:
24.00