SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3top'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4001_1
(SERUM ALBUMIN)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		4 / 5 ARG A1681
ALA A1739
ASP A1690
GLY A1688
 None
 1.17A 1e7bA-3topA:
undetectable		 1e7bA-3topA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		5 / 12 GLY A1755
ARG A1730
ASP A1753
PHE A1751
ALA A1769
 None
 1.30A 1oltA-3topA:
undetectable		 1oltA-3topA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		5 / 12 PHE A1848
ALA A1746
LEU A1794
GLY A1747
LEU A1750
 None
 1.24A 1qabF-3topA:
undetectable		 1qabF-3topA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		3 / 3 ILE A1120
ASP A1213
PHE A1214
 None
 0.58A 1uwjB-3topA:
undetectable		 1uwjB-3topA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XR2_B_C2FB1201_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		4 / 8 LYS A1460
THR A1528
SER A1166
GLU A1543
 ACR  A   1 ( 3.7A)
ACR  A   1 ( 4.6A)
None
None
 1.42A 1xr2B-3topA:
8.0		 1xr2B-3topA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		4 / 7 LEU A1484
GLY A1486
THR A1509
ILE A1549
 None
 0.95A 2bdmA-3topA:
undetectable		 2bdmA-3topA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_1
(VITAMIN D RECEPTOR)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		5 / 12 PHE A1677
LEU A1661
VAL A1662
SER A1663
LEU A1622
 None
 1.38A 2hc4A-3topA:
undetectable		 2hc4A-3topA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		5 / 11 GLY A1540
ASP A1526
ASN A1527
GLY A1553
PHE A1559
 None
ACR  A   1 (-2.8A)
None
None
ACR  A   1 (-4.3A)
 1.09A 2hmaA-3topA:
undetectable		 2hmaA-3topA:
17.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QMJ_A_ACRA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		6 / 12 ASP A1157
ASP A1279
ILE A1280
ASP A1526
PHE A1559
HIS A1584
 ACR  A   1 (-2.6A)
ACR  A   1 (-3.2A)
ACR  A   1 (-4.1A)
ACR  A   1 (-2.8A)
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
 1.22A 2qmjA-3topA:
48.8		 2qmjA-3topA:
43.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QMJ_A_ACRA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		10 / 12 ASP A1157
ASP A1279
ILE A1280
ILE A1315
TRP A1355
ASP A1420
ARG A1510
ASP A1526
PHE A1559
HIS A1584
 ACR  A   1 (-2.6A)
ACR  A   1 (-3.2A)
ACR  A   1 (-4.1A)
None
ACR  A   1 (-4.4A)
ACR  A   1 (-3.6A)
ACR  A   1 (-2.9A)
ACR  A   1 (-2.8A)
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
 0.39A 2qmjA-3topA:
48.8		 2qmjA-3topA:
43.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QMJ_A_ACRA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		5 / 12 ASP A1526
ASP A1317
ILE A1315
ILE A1280
ASP A1157
 ACR  A   1 (-2.8A)
ACR  A   1 ( 4.6A)
None
ACR  A   1 (-4.1A)
ACR  A   1 (-2.6A)
 1.08A 2qmjA-3topA:
48.8		 2qmjA-3topA:
43.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2QMJ_A_ACRA1001_2
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		5 / 6 TYR A1251
TRP A1418
MET A1421
TRP A1523
THR A1528
 ACR  A   1 ( 4.1A)
None
ACR  A   1 (-3.5A)
ACR  A   1 (-4.5A)
ACR  A   1 ( 4.6A)
 0.31A 2qmjA-3topA:
48.8		 2qmjA-3topA:
43.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		4 / 8 TYR A1162
TYR A1167
LEU A1450
THR A1552
 None
 0.99A 2v0zO-3topA:
undetectable		 2v0zO-3topA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		7 / 12 ASP A1157
GLN A1158
ASP A1279
ASP A1420
ASP A1526
PHE A1559
HIS A1584
 ACR  A   1 (-2.6A)
ACR  A   1 ( 4.8A)
ACR  A   1 (-3.2A)
ACR  A   1 (-3.6A)
ACR  A   1 (-2.8A)
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
 1.00A 2x2iA-3topA:
32.8		 2x2iA-3topA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_2
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		4 / 6 MET A1421
ARG A1510
TRP A1523
THR A1586
 ACR  A   1 (-3.5A)
ACR  A   1 (-2.9A)
ACR  A   1 (-4.5A)
None
 0.85A 2x2iA-3topA:
32.8		 2x2iA-3topA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_2
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		4 / 6 TRP A1418
MET A1421
ARG A1510
TRP A1523
 None
ACR  A   1 (-3.5A)
ACR  A   1 (-2.9A)
ACR  A   1 (-4.5A)
 0.58A 2x2iA-3topA:
32.8		 2x2iA-3topA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		8 / 12 ASP A1157
GLN A1158
ASP A1279
ASP A1420
MET A1421
ASP A1526
PHE A1559
HIS A1584
 ACR  A   1 (-2.6A)
ACR  A   1 ( 4.8A)
ACR  A   1 (-3.2A)
ACR  A   1 (-3.6A)
ACR  A   1 (-3.5A)
ACR  A   1 (-2.8A)
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
 0.96A 2x2iB-3topA:
32.8		 2x2iB-3topA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1050_2
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		4 / 6 TRP A1418
ARG A1510
TRP A1523
THR A1586
 None
ACR  A   1 (-2.9A)
ACR  A   1 (-4.5A)
None
 1.04A 2x2iB-3topA:
32.8		 2x2iB-3topA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		8 / 12 ASP A1157
GLN A1158
ASP A1279
ASP A1420
MET A1421
ASP A1526
PHE A1559
HIS A1584
 ACR  A   1 (-2.6A)
ACR  A   1 ( 4.8A)
ACR  A   1 (-3.2A)
ACR  A   1 (-3.6A)
ACR  A   1 (-3.5A)
ACR  A   1 (-2.8A)
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
 0.97A 2x2iC-3topA:
32.7		 2x2iC-3topA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1050_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		8 / 12 ASP A1157
GLN A1158
ASP A1279
ASP A1420
MET A1421
ASP A1526
PHE A1559
HIS A1584
 ACR  A   1 (-2.6A)
ACR  A   1 ( 4.8A)
ACR  A   1 (-3.2A)
ACR  A   1 (-3.6A)
ACR  A   1 (-3.5A)
ACR  A   1 (-2.8A)
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
 0.95A 2x2iD-3topA:
34.4		 2x2iD-3topA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		5 / 11 THR A1490
GLY A1517
PHE A1544
HIS A1170
ILE A1549
 None
 1.27A 2y7kA-3topA:
undetectable		 2y7kA-3topA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1303_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		4 / 7 PRO A1514
SER A1516
ILE A1549
GLY A1168
 None
 0.72A 2y7kA-3topA:
undetectable		 2y7kA-3topA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_C_SALC1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		5 / 12 THR A1490
GLY A1517
PHE A1544
HIS A1170
ILE A1549
 None
 1.28A 2y7kC-3topA:
undetectable		 2y7kC-3topA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1000_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		5 / 10 THR A1490
GLY A1517
PHE A1544
HIS A1170
ILE A1549
 None
 1.25A 2y7pA-3topA:
undetectable		 2y7pA-3topA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		4 / 8 TYR A1205
TYR A1172
PHE A1214
ILE A1094
 None
 1.02A 3jz0B-3topA:
undetectable		 3jz0B-3topA:
15.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3L4W_A_MIGA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		6 / 12 ASP A1279
ILE A1280
MET A1421
ASP A1526
PHE A1559
HIS A1584
 ACR  A   1 (-3.2A)
ACR  A   1 (-4.1A)
ACR  A   1 (-3.5A)
ACR  A   1 (-2.8A)
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
 1.42A 3l4wA-3topA:
48.6		 3l4wA-3topA:
43.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3L4W_A_MIGA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		12 / 12 TYR A1251
ASP A1279
ILE A1280
ILE A1315
TRP A1355
TRP A1418
ASP A1420
MET A1421
TRP A1523
ASP A1526
PHE A1559
HIS A1584
 ACR  A   1 ( 4.1A)
ACR  A   1 (-3.2A)
ACR  A   1 (-4.1A)
None
ACR  A   1 (-4.4A)
None
ACR  A   1 (-3.6A)
ACR  A   1 (-3.5A)
ACR  A   1 (-4.5A)
ACR  A   1 (-2.8A)
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
 0.62A 3l4wA-3topA:
48.6		 3l4wA-3topA:
43.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA309_1
(BETA-LACTAMASE)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		4 / 5 ILE A1508
THR A1512
GLU A1423
GLU A1136
 None
 1.33A 3ny4A-3topA:
undetectable		 3ny4A-3topA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_A_ACRA701_1
(ALPHA-GLUCOSIDASE)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		6 / 12 ASP A1157
ASP A1279
ILE A1280
ASP A1526
PHE A1559
HIS A1584
 ACR  A   1 (-2.6A)
ACR  A   1 (-3.2A)
ACR  A   1 (-4.1A)
ACR  A   1 (-2.8A)
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
 1.36A 3phaA-3topA:
37.4		 3phaA-3topA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_A_ACRA701_1
(ALPHA-GLUCOSIDASE)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		11 / 12 ASP A1157
ASP A1279
ILE A1280
ILE A1315
TRP A1355
ASP A1420
ARG A1510
TRP A1523
ASP A1526
PHE A1559
HIS A1584
 ACR  A   1 (-2.6A)
ACR  A   1 (-3.2A)
ACR  A   1 (-4.1A)
None
ACR  A   1 (-4.4A)
ACR  A   1 (-3.6A)
ACR  A   1 (-2.9A)
ACR  A   1 (-4.5A)
ACR  A   1 (-2.8A)
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
 0.41A 3phaA-3topA:
37.4		 3phaA-3topA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_A_ACRA701_1
(ALPHA-GLUCOSIDASE)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		5 / 12 ASP A1526
ASP A1317
ILE A1315
ILE A1280
ASP A1157
 ACR  A   1 (-2.8A)
ACR  A   1 ( 4.6A)
None
ACR  A   1 (-4.1A)
ACR  A   1 (-2.6A)
 1.07A 3phaA-3topA:
37.4		 3phaA-3topA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_B_ACRB701_1
(ALPHA-GLUCOSIDASE)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		6 / 12 ASP A1157
ASP A1279
ILE A1280
ASP A1526
PHE A1559
HIS A1584
 ACR  A   1 (-2.6A)
ACR  A   1 (-3.2A)
ACR  A   1 (-4.1A)
ACR  A   1 (-2.8A)
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
 1.39A 3phaB-3topA:
37.7		 3phaB-3topA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_B_ACRB701_1
(ALPHA-GLUCOSIDASE)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		10 / 12 ASP A1157
ASP A1279
ILE A1280
ILE A1315
TRP A1355
ASP A1420
ARG A1510
ASP A1526
PHE A1559
HIS A1584
 ACR  A   1 (-2.6A)
ACR  A   1 (-3.2A)
ACR  A   1 (-4.1A)
None
ACR  A   1 (-4.4A)
ACR  A   1 (-3.6A)
ACR  A   1 (-2.9A)
ACR  A   1 (-2.8A)
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
 0.45A 3phaB-3topA:
37.7		 3phaB-3topA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_B_ACRB701_2
(ALPHA-GLUCOSIDASE)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		4 / 5 PRO A1159
TYR A1251
MET A1421
TRP A1523
 ACR  A   1 (-3.9A)
ACR  A   1 ( 4.1A)
ACR  A   1 (-3.5A)
ACR  A   1 (-4.5A)
 0.81A 3phaB-3topA:
37.7		 3phaB-3topA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_C_ACRC701_1
(ALPHA-GLUCOSIDASE)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		10 / 12 ASP A1157
ASP A1279
ILE A1280
TRP A1355
ASP A1420
ARG A1510
TRP A1523
ASP A1526
PHE A1559
HIS A1584
 ACR  A   1 (-2.6A)
ACR  A   1 (-3.2A)
ACR  A   1 (-4.1A)
ACR  A   1 (-4.4A)
ACR  A   1 (-3.6A)
ACR  A   1 (-2.9A)
ACR  A   1 (-4.5A)
ACR  A   1 (-2.8A)
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
 0.42A 3phaC-3topA:
38.3		 3phaC-3topA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_C_ACRC701_1
(ALPHA-GLUCOSIDASE)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		6 / 12 ASP A1157
ASP A1279
ILE A1315
ARG A1510
ASP A1526
PHE A1559
 ACR  A   1 (-2.6A)
ACR  A   1 (-3.2A)
None
ACR  A   1 (-2.9A)
ACR  A   1 (-2.8A)
ACR  A   1 (-4.3A)
 1.49A 3phaC-3topA:
38.3		 3phaC-3topA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_D_ACRD701_1
(ALPHA-GLUCOSIDASE)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		10 / 12 ASP A1157
ASP A1279
ILE A1280
TRP A1355
ASP A1420
MET A1421
ARG A1510
ASP A1526
PHE A1559
HIS A1584
 ACR  A   1 (-2.6A)
ACR  A   1 (-3.2A)
ACR  A   1 (-4.1A)
ACR  A   1 (-4.4A)
ACR  A   1 (-3.6A)
ACR  A   1 (-3.5A)
ACR  A   1 (-2.9A)
ACR  A   1 (-2.8A)
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
 0.39A 3phaD-3topA:
38.7		 3phaD-3topA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_A_ACRA664_1
(ALPHA-GLUCOSIDASE)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		10 / 12 ASP A1279
ILE A1280
ILE A1315
TRP A1355
MET A1421
ARG A1510
TRP A1523
ASP A1526
PHE A1559
HIS A1584
 ACR  A   1 (-3.2A)
ACR  A   1 (-4.1A)
None
ACR  A   1 (-4.4A)
ACR  A   1 (-3.5A)
ACR  A   1 (-2.9A)
ACR  A   1 (-4.5A)
ACR  A   1 (-2.8A)
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
 0.42A 3pocA-3topA:
38.6		 3pocA-3topA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_A_ACRA664_1
(ALPHA-GLUCOSIDASE)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		8 / 12 ASP A1279
ILE A1280
ILE A1315
TRP A1355
TRP A1418
ASP A1526
PHE A1559
HIS A1584
 ACR  A   1 (-3.2A)
ACR  A   1 (-4.1A)
None
ACR  A   1 (-4.4A)
None
ACR  A   1 (-2.8A)
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
 0.91A 3pocA-3topA:
38.6		 3pocA-3topA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_B_ACRB664_1
(ALPHA-GLUCOSIDASE)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		10 / 12 ASP A1279
ILE A1280
ILE A1315
TRP A1355
MET A1421
ARG A1510
TRP A1523
ASP A1526
PHE A1559
HIS A1584
 ACR  A   1 (-3.2A)
ACR  A   1 (-4.1A)
None
ACR  A   1 (-4.4A)
ACR  A   1 (-3.5A)
ACR  A   1 (-2.9A)
ACR  A   1 (-4.5A)
ACR  A   1 (-2.8A)
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
 0.42A 3pocB-3topA:
38.7		 3pocB-3topA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_B_ACRB664_1
(ALPHA-GLUCOSIDASE)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		7 / 12 ASP A1279
ILE A1280
ILE A1315
TRP A1355
TRP A1418
PHE A1559
HIS A1584
 ACR  A   1 (-3.2A)
ACR  A   1 (-4.1A)
None
ACR  A   1 (-4.4A)
None
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
 0.99A 3pocB-3topA:
38.7		 3pocB-3topA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_D_EVPD1_1
(DNA TOPOISOMERASE
2-BETA)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		4 / 5 GLY A1334
ASP A1337
ARG A1333
MET A1417
 None
 0.98A 3qx3B-3topA:
undetectable		 3qx3B-3topA:
22.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3O_A_DLUA399_1
(PFV INTEGRASE)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		4 / 7 ASP A 960
TYR A 997
GLN A1198
GLU A 961
 None
 1.27A 3s3oA-3topA:
undetectable		 3s3oA-3topA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_3
(NS3 PROTEASE, NS4A
PROTEIN)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		4 / 5 SER A1515
PRO A1171
TYR A1172
VAL A1169
 None
 1.18A 3sufC-3topA:
undetectable		 3sufC-3topA:
12.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3W37_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		6 / 12 ASP A1157
ASP A1279
ILE A1280
MET A1421
ASP A1526
PHE A1559
 ACR  A   1 (-2.6A)
ACR  A   1 (-3.2A)
ACR  A   1 (-4.1A)
ACR  A   1 (-3.5A)
ACR  A   1 (-2.8A)
ACR  A   1 (-4.3A)
 1.40A 3w37A-3topA:
44.9		 3w37A-3topA:
34.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3W37_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		10 / 12 ASP A1157
ASP A1279
ILE A1315
TRP A1418
ASP A1420
MET A1421
ARG A1510
ASP A1526
PHE A1559
HIS A1584
 ACR  A   1 (-2.6A)
ACR  A   1 (-3.2A)
None
None
ACR  A   1 (-3.6A)
ACR  A   1 (-3.5A)
ACR  A   1 (-2.9A)
ACR  A   1 (-2.8A)
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
 0.37A 3w37A-3topA:
44.9		 3w37A-3topA:
34.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WEL_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		5 / 12 ASP A1157
ASP A1279
ILE A1280
ASP A1526
PHE A1559
 ACR  A   1 (-2.6A)
ACR  A   1 (-3.2A)
ACR  A   1 (-4.1A)
ACR  A   1 (-2.8A)
ACR  A   1 (-4.3A)
 1.34A 3welA-3topA:
45.0		 3welA-3topA:
34.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WEL_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		9 / 12 ASP A1157
ASP A1279
ILE A1315
TRP A1418
ASP A1420
ARG A1510
ASP A1526
PHE A1559
HIS A1584
 ACR  A   1 (-2.6A)
ACR  A   1 (-3.2A)
None
None
ACR  A   1 (-3.6A)
ACR  A   1 (-2.9A)
ACR  A   1 (-2.8A)
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
 0.34A 3welA-3topA:
45.0		 3welA-3topA:
34.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WEL_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		4 / 6 ILE A1280
TRP A1355
MET A1421
TRP A1523
 ACR  A   1 (-4.1A)
ACR  A   1 (-4.4A)
ACR  A   1 (-3.5A)
ACR  A   1 (-4.5A)
 0.34A 3welA-3topA:
45.0		 3welA-3topA:
34.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WEM_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		9 / 12 ASP A1157
ASP A1279
ILE A1280
ASP A1420
MET A1421
ARG A1510
ASP A1526
PHE A1559
HIS A1584
 ACR  A   1 (-2.6A)
ACR  A   1 (-3.2A)
ACR  A   1 (-4.1A)
ACR  A   1 (-3.6A)
ACR  A   1 (-3.5A)
ACR  A   1 (-2.9A)
ACR  A   1 (-2.8A)
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
 0.41A 3wemA-3topA:
44.5		 3wemA-3topA:
34.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WEN_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		10 / 12 ASP A1157
ASP A1279
ILE A1280
TRP A1418
ASP A1420
MET A1421
ARG A1510
ASP A1526
PHE A1559
HIS A1584
 ACR  A   1 (-2.6A)
ACR  A   1 (-3.2A)
ACR  A   1 (-4.1A)
None
ACR  A   1 (-3.6A)
ACR  A   1 (-3.5A)
ACR  A   1 (-2.9A)
ACR  A   1 (-2.8A)
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
 0.41A 3wenA-3topA:
44.6		 3wenA-3topA:
34.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WEO_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		9 / 12 ASP A1157
ASP A1279
ILE A1280
TRP A1418
ASP A1420
ARG A1510
ASP A1526
PHE A1559
HIS A1584
 ACR  A   1 (-2.6A)
ACR  A   1 (-3.2A)
ACR  A   1 (-4.1A)
None
ACR  A   1 (-3.6A)
ACR  A   1 (-2.9A)
ACR  A   1 (-2.8A)
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
 0.38A 3weoA-3topA:
45.0		 3weoA-3topA:
34.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3WEO_A_ACRA1001_2
(ALPHA-GLUCOSIDASE)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		4 / 6 ILE A1315
TRP A1355
MET A1421
TRP A1523
 None
ACR  A   1 (-4.4A)
ACR  A   1 (-3.5A)
ACR  A   1 (-4.5A)
 0.36A 3weoA-3topA:
45.0		 3weoA-3topA:
34.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B9Z_A_ACRA1818_1
(ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		5 / 12 ASP A1279
ILE A1280
ASP A1526
PHE A1559
HIS A1584
 ACR  A   1 (-3.2A)
ACR  A   1 (-4.1A)
ACR  A   1 (-2.8A)
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
 1.22A 4b9zA-3topA:
34.3		 4b9zA-3topA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B9Z_A_ACRA1818_1
(ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		7 / 12 ASP A1279
ILE A1315
ASP A1420
ARG A1510
ASP A1526
PHE A1559
HIS A1584
 ACR  A   1 (-3.2A)
None
ACR  A   1 (-3.6A)
ACR  A   1 (-2.9A)
ACR  A   1 (-2.8A)
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
 0.45A 4b9zA-3topA:
34.3		 4b9zA-3topA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B9Z_A_ACRA1818_1
(ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		7 / 12 ASP A1279
ILE A1315
ASP A1420
GLU A1423
ARG A1510
ASP A1526
HIS A1584
 ACR  A   1 (-3.2A)
None
ACR  A   1 (-3.6A)
None
ACR  A   1 (-2.9A)
ACR  A   1 (-2.8A)
ACR  A   1 (-3.9A)
 1.36A 4b9zA-3topA:
34.3		 4b9zA-3topA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_E_KANE301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		5 / 11 HIS A1522
ASP A1420
ASP A1157
ASP A1555
GLU A1136
 None
ACR  A   1 (-3.6A)
ACR  A   1 (-2.6A)
None
None
 1.34A 4fevE-3topA:
0.6		 4fevE-3topA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_I_KANI301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		5 / 11 ASP A1420
ASP A1157
ASP A1555
GLU A1136
HIS A1522
 ACR  A   1 (-3.6A)
ACR  A   1 (-2.6A)
None
None
None
 1.40A 4gkhI-3topA:
0.0
4gkhJ-3topA:
2.0		 4gkhI-3topA:
14.57
4gkhJ-3topA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_L_KANL301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		5 / 10 HIS A1522
ASP A1420
ASP A1157
ASP A1555
GLU A1136
 None
ACR  A   1 (-3.6A)
ACR  A   1 (-2.6A)
None
None
 1.30A 4gkhK-3topA:
0.0
4gkhL-3topA:
0.0		 4gkhK-3topA:
14.57
4gkhL-3topA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_H_KANH301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		5 / 10 HIS A1522
ASP A1420
ASP A1157
ASP A1555
GLU A1136
 None
ACR  A   1 (-3.6A)
ACR  A   1 (-2.6A)
None
None
 1.34A 4gkiG-3topA:
0.0
4gkiH-3topA:
1.4		 4gkiG-3topA:
14.57
4gkiH-3topA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_L_KANL301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		5 / 12 HIS A1522
ASP A1420
ASP A1157
ASP A1555
GLU A1136
 None
ACR  A   1 (-3.6A)
ACR  A   1 (-2.6A)
None
None
 1.42A 4gkiK-3topA:
0.9
4gkiL-3topA:
1.3		 4gkiK-3topA:
14.57
4gkiL-3topA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_A_H4BA804_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		4 / 7 MET A1421
VAL A1354
TRP A1355
GLU A1423
 ACR  A   1 (-3.5A)
None
ACR  A   1 (-4.4A)
None
 1.19A 4jseA-3topA:
undetectable
4jseB-3topA:
undetectable		 4jseA-3topA:
18.20
4jseB-3topA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		4 / 7 GLU A1423
MET A1421
VAL A1354
TRP A1355
 None
ACR  A   1 (-3.5A)
None
ACR  A   1 (-4.4A)
 1.19A 4jseA-3topA:
undetectable
4jseB-3topA:
undetectable		 4jseA-3topA:
18.20
4jseB-3topA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		3 / 3 LEU A1638
ARG A1635
MET A1623
 None
 0.82A 4m11C-3topA:
undetectable		 4m11C-3topA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA302_1
(CHITOSANASE)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		4 / 5 THR A1150
THR A1196
ASP A1194
TYR A1446
 None
 1.02A 4oltA-3topA:
undetectable		 4oltA-3topA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB302_1
(CHITOSANASE)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		4 / 5 THR A1150
THR A1196
ASP A1194
TYR A1446
 None
 1.04A 4oltB-3topA:
undetectable		 4oltB-3topA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAE_A_NIZA804_1
(CATALASE-PEROXIDASE)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		4 / 6 ASP A1684
TYR A1685
LEU A1709
HIS A1706
 None
 1.17A 4paeA-3topA:
undetectable		 4paeA-3topA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA302_1
(CHITOSANASE)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		4 / 5 THR A1150
THR A1196
ASP A1194
TYR A1446
 None
 1.04A 4qwpA-3topA:
undetectable		 4qwpA-3topA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB306_1
(CHITOSANASE)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		4 / 5 THR A1150
THR A1196
ASP A1194
TYR A1446
 None
 1.05A 4qwpB-3topA:
undetectable		 4qwpB-3topA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		5 / 12 GLY A1334
GLY A1505
GLY A1416
LEU A1316
PHE A1385
 None
 1.13A 5eqbA-3topA:
undetectable		 5eqbA-3topA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEF_A_NBVA1005_1
(NEUTRAL
ALPHA-GLUCOSIDASE AB)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		10 / 12 ASP A1279
ILE A1280
ILE A1315
TRP A1418
ASP A1420
MET A1421
PHE A1427
ASP A1526
PHE A1559
HIS A1584
 ACR  A   1 (-3.2A)
ACR  A   1 (-4.1A)
None
None
ACR  A   1 (-3.6A)
ACR  A   1 (-3.5A)
None
ACR  A   1 (-2.8A)
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
 0.53A 5iefA-3topA:
38.9		 5iefA-3topA:
27.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEF_A_NBVA1005_1
(NEUTRAL
ALPHA-GLUCOSIDASE AB)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		6 / 12 ASP A1279
ILE A1280
MET A1421
ASP A1526
PHE A1559
HIS A1584
 ACR  A   1 (-3.2A)
ACR  A   1 (-4.1A)
ACR  A   1 (-3.5A)
ACR  A   1 (-2.8A)
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
 1.46A 5iefA-3topA:
38.9		 5iefA-3topA:
27.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEF_A_NBVA1005_2
(NEUTRAL
ALPHA-GLUCOSIDASE AB)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		4 / 4 ARG A1510
TRP A1523
ASP A1555
ARG A1582
 ACR  A   1 (-2.9A)
ACR  A   1 (-4.5A)
None
None
 0.29A 5iefA-3topA:
38.9		 5iefA-3topA:
27.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		3 / 3 TYR A1551
TYR A1277
GLN A1247
 None
 0.82A 5jsdA-3topA:
undetectable
5jsdB-3topA:
undetectable		 5jsdA-3topA:
21.11
5jsdB-3topA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		3 / 3 TYR A1551
TYR A1277
GLN A1247
 None
 0.83A 5jsdB-3topA:
undetectable
5jsdC-3topA:
0.9		 5jsdB-3topA:
21.11
5jsdC-3topA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_1
(METHYLTRANSFERASE)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		4 / 7 GLY A1558
PHE A1560
ARG A1591
ASP A1555
 None
ACR  A   1 (-3.7A)
None
None
 0.97A 5n5dB-3topA:
undetectable		 5n5dB-3topA:
13.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NN6_A_MIGA1013_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		10 / 12 ASP A1279
ILE A1315
TRP A1355
TRP A1418
ASP A1420
MET A1421
TRP A1523
ASP A1526
PHE A1559
HIS A1584
 ACR  A   1 (-3.2A)
None
ACR  A   1 (-4.4A)
None
ACR  A   1 (-3.6A)
ACR  A   1 (-3.5A)
ACR  A   1 (-4.5A)
ACR  A   1 (-2.8A)
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
 0.71A 5nn6A-3topA:
48.3		 5nn6A-3topA:
39.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NN8_A_ACRA1015_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		5 / 12 ASP A1157
ASP A1279
ILE A1280
ASP A1526
PHE A1559
 ACR  A   1 (-2.6A)
ACR  A   1 (-3.2A)
ACR  A   1 (-4.1A)
ACR  A   1 (-2.8A)
ACR  A   1 (-4.3A)
 1.32A 5nn8A-3topA:
48.4		 5nn8A-3topA:
39.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NN8_A_ACRA1015_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		10 / 12 ASP A1157
ASP A1279
ILE A1315
TRP A1355
TRP A1418
ASP A1420
ARG A1510
ASP A1526
PHE A1559
HIS A1584
 ACR  A   1 (-2.6A)
ACR  A   1 (-3.2A)
None
ACR  A   1 (-4.4A)
None
ACR  A   1 (-3.6A)
ACR  A   1 (-2.9A)
ACR  A   1 (-2.8A)
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
 0.42A 5nn8A-3topA:
48.4		 5nn8A-3topA:
39.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5P9I_A_1E8A701_2
(TYROSINE-PROTEIN
KINASE BTK)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		4 / 5 LEU A1126
TYR A1173
MET A1174
ASP A1649
 None
 1.15A 5p9iA-3topA:
1.2		 5p9iA-3topA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		5 / 12 PHE A1115
GLY A1209
THR A1207
LEU A1187
PHE A1052
 None
 1.38A 5v5zA-3topA:
undetectable		 5v5zA-3topA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_1
(REGULATORY PROTEIN
TETR)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		4 / 8 GLY A1014
ARG A1039
VAL A1042
ASP A1041
 None
 0.89A 5vlmA-3topA:
undetectable		 5vlmA-3topA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_1
(MRNA CAPPING ENZYME
P5)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		3 / 3 TYR A1167
ASP A1420
ASP A1157
 None
ACR  A   1 (-3.6A)
ACR  A   1 (-2.6A)
 0.84A 5x6yA-3topA:
undetectable		 5x6yA-3topA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1401_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		7 / 10 TRP A1418
ASP A1420
ARG A1510
TRP A1523
ASP A1526
PHE A1559
HIS A1584
 None
ACR  A   1 (-3.6A)
ACR  A   1 (-2.9A)
ACR  A   1 (-4.5A)
ACR  A   1 (-2.8A)
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
 0.53A 5x7pA-3topA:
24.7		 5x7pA-3topA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9X_A_VOGA701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		10 / 12 ASP A1157
ILE A1280
ILE A1315
TRP A1355
ASP A1420
MET A1421
ARG A1510
TRP A1523
PHE A1559
HIS A1584
 ACR  A   1 (-2.6A)
ACR  A   1 (-4.1A)
None
ACR  A   1 (-4.4A)
ACR  A   1 (-3.6A)
ACR  A   1 (-3.5A)
ACR  A   1 (-2.9A)
ACR  A   1 (-4.5A)
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
 0.41A 6c9xA-3topA:
34.5		 6c9xA-3topA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9X_A_VOGA701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		6 / 12 ASP A1157
ILE A1315
MET A1421
ARG A1510
PHE A1559
HIS A1584
 ACR  A   1 (-2.6A)
None
ACR  A   1 (-3.5A)
ACR  A   1 (-2.9A)
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
 1.27A 6c9xA-3topA:
34.5		 6c9xA-3topA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9X_A_VOGA701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		6 / 12 ILE A1280
ILE A1315
TRP A1355
TRP A1418
PHE A1559
HIS A1584
 ACR  A   1 (-4.1A)
None
ACR  A   1 (-4.4A)
None
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
 0.94A 6c9xA-3topA:
34.5		 6c9xA-3topA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9X_B_VOGB701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		10 / 12 ASP A1157
ILE A1280
ILE A1315
TRP A1355
ASP A1420
MET A1421
ARG A1510
TRP A1523
PHE A1559
HIS A1584
 ACR  A   1 (-2.6A)
ACR  A   1 (-4.1A)
None
ACR  A   1 (-4.4A)
ACR  A   1 (-3.6A)
ACR  A   1 (-3.5A)
ACR  A   1 (-2.9A)
ACR  A   1 (-4.5A)
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
 0.42A 6c9xB-3topA:
37.4		 6c9xB-3topA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9X_B_VOGB701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		5 / 12 ASP A1157
ILE A1280
MET A1421
PHE A1559
HIS A1584
 ACR  A   1 (-2.6A)
ACR  A   1 (-4.1A)
ACR  A   1 (-3.5A)
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
 1.39A 6c9xB-3topA:
37.4		 6c9xB-3topA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9X_B_VOGB701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		5 / 12 ASP A1157
ILE A1315
MET A1421
ARG A1510
PHE A1559
 ACR  A   1 (-2.6A)
None
ACR  A   1 (-3.5A)
ACR  A   1 (-2.9A)
ACR  A   1 (-4.3A)
 1.14A 6c9xB-3topA:
37.4		 6c9xB-3topA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9X_B_VOGB701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		6 / 12 ILE A1280
ILE A1315
TRP A1355
TRP A1418
PHE A1559
HIS A1584
 ACR  A   1 (-4.1A)
None
ACR  A   1 (-4.4A)
None
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
 0.94A 6c9xB-3topA:
37.4		 6c9xB-3topA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9Z_A_VOGA701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		5 / 12 ILE A1280
MET A1421
ASP A1526
PHE A1559
HIS A1584
 ACR  A   1 (-4.1A)
ACR  A   1 (-3.5A)
ACR  A   1 (-2.8A)
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
 1.38A 6c9zA-3topA:
33.4		 6c9zA-3topA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9Z_A_VOGA701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		11 / 12 TYR A1251
ILE A1280
ILE A1315
TRP A1355
ASP A1420
MET A1421
ARG A1510
TRP A1523
ASP A1526
PHE A1559
HIS A1584
 ACR  A   1 ( 4.1A)
ACR  A   1 (-4.1A)
None
ACR  A   1 (-4.4A)
ACR  A   1 (-3.6A)
ACR  A   1 (-3.5A)
ACR  A   1 (-2.9A)
ACR  A   1 (-4.5A)
ACR  A   1 (-2.8A)
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
 0.42A 6c9zA-3topA:
33.4		 6c9zA-3topA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9Z_A_VOGA701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		7 / 12 TYR A1251
ILE A1280
ILE A1315
TRP A1355
TRP A1418
PHE A1559
HIS A1584
 ACR  A   1 ( 4.1A)
ACR  A   1 (-4.1A)
None
ACR  A   1 (-4.4A)
None
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
 0.96A 6c9zA-3topA:
33.4		 6c9zA-3topA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9Z_A_VOGA701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		5 / 12 TYR A1251
TRP A1355
MET A1421
ASP A1526
PHE A1560
 ACR  A   1 ( 4.1A)
ACR  A   1 (-4.4A)
ACR  A   1 (-3.5A)
ACR  A   1 (-2.8A)
ACR  A   1 (-3.7A)
 1.44A 6c9zA-3topA:
33.4		 6c9zA-3topA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9Z_B_VOGB701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		5 / 12 ASP A1157
ILE A1280
MET A1421
PHE A1559
HIS A1584
 ACR  A   1 (-2.6A)
ACR  A   1 (-4.1A)
ACR  A   1 (-3.5A)
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
 1.34A 6c9zB-3topA:
34.5		 6c9zB-3topA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9Z_B_VOGB701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		5 / 12 ASP A1157
ILE A1315
MET A1421
ARG A1510
PHE A1559
 ACR  A   1 (-2.6A)
None
ACR  A   1 (-3.5A)
ACR  A   1 (-2.9A)
ACR  A   1 (-4.3A)
 1.09A 6c9zB-3topA:
34.5		 6c9zB-3topA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9Z_B_VOGB701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		11 / 12 ASP A1157
TYR A1251
ILE A1280
ILE A1315
TRP A1355
ASP A1420
MET A1421
ARG A1510
TRP A1523
PHE A1559
HIS A1584
 ACR  A   1 (-2.6A)
ACR  A   1 ( 4.1A)
ACR  A   1 (-4.1A)
None
ACR  A   1 (-4.4A)
ACR  A   1 (-3.6A)
ACR  A   1 (-3.5A)
ACR  A   1 (-2.9A)
ACR  A   1 (-4.5A)
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
 0.45A 6c9zB-3topA:
34.5		 6c9zB-3topA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9Z_B_VOGB701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		5 / 12 ASP A1157
TYR A1251
TRP A1355
MET A1421
PHE A1560
 ACR  A   1 (-2.6A)
ACR  A   1 ( 4.1A)
ACR  A   1 (-4.4A)
ACR  A   1 (-3.5A)
ACR  A   1 (-3.7A)
 1.19A 6c9zB-3topA:
34.5		 6c9zB-3topA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C9Z_B_VOGB701_0
(GLYCOSYL HYDROLASE,
FAMILY 31)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		7 / 12 TYR A1251
ILE A1280
ILE A1315
TRP A1355
TRP A1418
PHE A1559
HIS A1584
 ACR  A   1 ( 4.1A)
ACR  A   1 (-4.1A)
None
ACR  A   1 (-4.4A)
None
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
 0.95A 6c9zB-3topA:
34.5		 6c9zB-3topA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		10 / 12 ASP A1279
ILE A1280
ILE A1315
ASP A1420
MET A1421
ARG A1510
TRP A1523
ASP A1526
PHE A1559
HIS A1584
 ACR  A   1 (-3.2A)
ACR  A   1 (-4.1A)
None
ACR  A   1 (-3.6A)
ACR  A   1 (-3.5A)
ACR  A   1 (-2.9A)
ACR  A   1 (-4.5A)
ACR  A   1 (-2.8A)
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
 0.45A 6ca1A-3topA:
38.5		 6ca1A-3topA:
6.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		6 / 12 ASP A1279
ILE A1280
ILE A1315
TRP A1418
PHE A1559
HIS A1584
 ACR  A   1 (-3.2A)
ACR  A   1 (-4.1A)
None
None
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
 0.85A 6ca1A-3topA:
38.5		 6ca1A-3topA:
6.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		8 / 12 ASP A1279
ILE A1315
ASP A1420
MET A1421
ARG A1510
ASP A1526
PHE A1559
HIS A1584
 ACR  A   1 (-3.2A)
None
ACR  A   1 (-3.6A)
ACR  A   1 (-3.5A)
ACR  A   1 (-2.9A)
ACR  A   1 (-2.8A)
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
 1.46A 6ca1A-3topA:
38.5		 6ca1A-3topA:
6.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		10 / 12 ASP A1279
ILE A1280
ILE A1315
ASP A1420
MET A1421
ARG A1510
TRP A1523
ASP A1526
PHE A1559
HIS A1584
 ACR  A   1 (-3.2A)
ACR  A   1 (-4.1A)
None
ACR  A   1 (-3.6A)
ACR  A   1 (-3.5A)
ACR  A   1 (-2.9A)
ACR  A   1 (-4.5A)
ACR  A   1 (-2.8A)
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
 0.44A 6ca1B-3topA:
36.9		 6ca1B-3topA:
6.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		6 / 12 ASP A1279
ILE A1280
ILE A1315
TRP A1418
PHE A1559
HIS A1584
 ACR  A   1 (-3.2A)
ACR  A   1 (-4.1A)
None
None
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
 0.87A 6ca1B-3topA:
36.9		 6ca1B-3topA:
6.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		11 / 12 TYR A1251
ASP A1279
ILE A1280
ILE A1315
ASP A1420
MET A1421
ARG A1510
TRP A1523
ASP A1526
PHE A1559
HIS A1584
 ACR  A   1 ( 4.1A)
ACR  A   1 (-3.2A)
ACR  A   1 (-4.1A)
None
ACR  A   1 (-3.6A)
ACR  A   1 (-3.5A)
ACR  A   1 (-2.9A)
ACR  A   1 (-4.5A)
ACR  A   1 (-2.8A)
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
 0.42A 6ca3A-3topA:
34.6		 6ca3A-3topA:
6.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		7 / 12 TYR A1251
ASP A1279
ILE A1280
ILE A1315
TRP A1418
PHE A1559
HIS A1584
 ACR  A   1 ( 4.1A)
ACR  A   1 (-3.2A)
ACR  A   1 (-4.1A)
None
None
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
 0.91A 6ca3A-3topA:
34.6		 6ca3A-3topA:
6.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		10 / 12 ASP A1279
ILE A1280
ILE A1315
ASP A1420
MET A1421
ARG A1510
TRP A1523
ASP A1526
PHE A1559
HIS A1584
 ACR  A   1 (-3.2A)
ACR  A   1 (-4.1A)
None
ACR  A   1 (-3.6A)
ACR  A   1 (-3.5A)
ACR  A   1 (-2.9A)
ACR  A   1 (-4.5A)
ACR  A   1 (-2.8A)
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
 0.43A 6ca3B-3topA:
33.4		 6ca3B-3topA:
6.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		9 / 12 ASP A1279
ILE A1280
ILE A1315
TRP A1355
ASP A1420
TRP A1523
ASP A1526
PHE A1559
HIS A1584
 ACR  A   1 (-3.2A)
ACR  A   1 (-4.1A)
None
ACR  A   1 (-4.4A)
ACR  A   1 (-3.6A)
ACR  A   1 (-4.5A)
ACR  A   1 (-2.8A)
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
 0.70A 6ca3B-3topA:
33.4		 6ca3B-3topA:
6.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens) 		7 / 12 ASP A1279
ILE A1280
ILE A1315
TRP A1355
TRP A1418
PHE A1559
HIS A1584
 ACR  A   1 (-3.2A)
ACR  A   1 (-4.1A)
None
ACR  A   1 (-4.4A)
None
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
 1.23A 6ca3B-3topA:
33.4		 6ca3B-3topA:
6.42