SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tot'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 3tot GLUTATHIONE
S-TRANSFERASE
PROTEIN
(Ralstonia
solanacearum) 		4 / 5 LEU A 137
ALA A 139
TRP A  95
LEU A  98
 None
 1.13A 2oaxA-3totA:
undetectable		 2oaxA-3totA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3tot GLUTATHIONE
S-TRANSFERASE
PROTEIN
(Ralstonia
solanacearum) 		5 / 10 ILE A   6
SER A  76
ALA A  22
LEU A  21
ALA A  72
 None
 1.43A 3lw5B-3totA:
undetectable		 3lw5B-3totA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)		 3tot GLUTATHIONE
S-TRANSFERASE
PROTEIN
(Ralstonia
solanacearum) 		4 / 6 ASN A 184
PHE A 188
ALA A 187
THR A 190
 None
 1.05A 3t3sB-3totA:
undetectable		 3t3sB-3totA:
18.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TOU_A_ACTA228_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 3tot GLUTATHIONE
S-TRANSFERASE
PROTEIN
(Ralstonia
solanacearum) 		4 / 4 ALA A  10
ARG A 110
TYR A 168
ARG A 172
 ACT  A 227 (-3.5A)
ACT  A 227 (-4.7A)
ACT  A 227 (-4.5A)
ACT  A 227 (-3.9A)
 0.04A 3touA-3totA:
38.7		 3touA-3totA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3TOU_B_ACTB228_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 3tot GLUTATHIONE
S-TRANSFERASE
PROTEIN
(Ralstonia
solanacearum) 		4 / 4 ALA A  10
ARG A 110
TYR A 168
ARG A 172
 ACT  A 227 (-3.5A)
ACT  A 227 (-4.7A)
ACT  A 227 (-4.5A)
ACT  A 227 (-3.9A)
 0.34A 3touB-3totA:
36.0		 3touB-3totA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7G_A_ACTA514_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3tot GLUTATHIONE
S-TRANSFERASE
PROTEIN
(Ralstonia
solanacearum) 		4 / 4 ALA A 158
VAL A 162
ASP A 159
LEU A 144
 None
 0.96A 4e7gA-3totA:
undetectable		 4e7gA-3totA:
22.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 3tot GLUTATHIONE
S-TRANSFERASE
PROTEIN
(Ralstonia
solanacearum) 		5 / 8 ALA A  10
SER A  11
ARG A 110
TYR A 168
ARG A 172
 ACT  A 227 (-3.5A)
ACT  A 231 (-2.5A)
ACT  A 227 (-4.7A)
ACT  A 227 (-4.5A)
ACT  A 227 (-3.9A)
 0.90A 4ijiF-3totA:
27.4		 4ijiF-3totA:
42.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IJI_H_BEZH501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 3tot GLUTATHIONE
S-TRANSFERASE
PROTEIN
(Ralstonia
solanacearum) 		4 / 7 ALA A  10
SER A  11
VAL A 107
ARG A 110
 ACT  A 227 (-3.5A)
ACT  A 231 (-2.5A)
ACT  A 231 ( 4.7A)
ACT  A 227 (-4.7A)
 1.07A 4ijiH-3totA:
27.0		 4ijiH-3totA:
42.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IJI_H_BEZH501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 3tot GLUTATHIONE
S-TRANSFERASE
PROTEIN
(Ralstonia
solanacearum) 		6 / 7 ALA A  10
SER A  11
VAL A 107
ARG A 110
TYR A 168
ARG A 172
 ACT  A 227 (-3.5A)
ACT  A 231 (-2.5A)
ACT  A 231 ( 4.7A)
ACT  A 227 (-4.7A)
ACT  A 227 (-4.5A)
ACT  A 227 (-3.9A)
 0.79A 4ijiH-3totA:
27.0		 4ijiH-3totA:
42.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSS_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3tot GLUTATHIONE
S-TRANSFERASE
PROTEIN
(Ralstonia
solanacearum) 		5 / 12 ALA A  99
MET A 140
LEU A 166
ALA A 167
ILE A 133
 None
 0.88A 4pssA-3totA:
undetectable		 4pssA-3totA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 3tot GLUTATHIONE
S-TRANSFERASE
PROTEIN
(Ralstonia
solanacearum) 		4 / 8 LEU A  54
VAL A  67
TYR A  71
LEU A  21
 None
 1.13A 4pwdC-3totA:
undetectable		 4pwdC-3totA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA604_0
(SERUM ALBUMIN)		 3tot GLUTATHIONE
S-TRANSFERASE
PROTEIN
(Ralstonia
solanacearum) 		4 / 8 ALA A 106
GLY A 101
LEU A 102
ALA A 165
 None
 0.74A 6mdqA-3totA:
2.3		 6mdqA-3totA:
13.27