SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3toy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 3toy MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Bradyrhizobium
sp.
ORS
278) 		4 / 8 GLU A 205
ARG A 208
ARG A 209
LEU A 201
 None
 0.92A 1cmaA-3toyA:
undetectable
1cmaB-3toyA:
undetectable		 1cmaA-3toyA:
15.49
1cmaB-3toyA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3toy MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Bradyrhizobium
sp.
ORS
278) 		5 / 10 ALA A 110
GLY A   8
THR A  46
THR A  40
ILE A   6
 None
 1.22A 1gtnB-3toyA:
undetectable
1gtnC-3toyA:
undetectable		 1gtnB-3toyA:
11.81
1gtnC-3toyA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3toy MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Bradyrhizobium
sp.
ORS
278) 		5 / 10 ALA A 110
GLY A   8
THR A  46
THR A  40
ILE A   6
 None
 1.20A 1gtnH-3toyA:
undetectable
1gtnI-3toyA:
undetectable		 1gtnH-3toyA:
11.81
1gtnI-3toyA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)		 3toy MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Bradyrhizobium
sp.
ORS
278) 		4 / 8 ILE A   6
THR A  41
PRO A  80
LEU A  78
 None
 0.89A 1hmyA-3toyA:
undetectable		 1hmyA-3toyA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 3toy MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Bradyrhizobium
sp.
ORS
278) 		5 / 11 LEU A 272
ILE A 278
GLU A 302
LEU A 317
LEU A 308
 None
 1.19A 1mrqA-3toyA:
5.5		 1mrqA-3toyA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_F_SC2F1291_1
(FICOLIN-2)		 3toy MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Bradyrhizobium
sp.
ORS
278) 		4 / 6 SER A 139
LEU A 320
ASP A 196
GLU A 248
 None
None
CA  A 361 ( 2.9A)
CA  A 361 ( 2.2A)
 1.11A 2j2pE-3toyA:
undetectable
2j2pF-3toyA:
undetectable		 2j2pE-3toyA:
20.79
2j2pF-3toyA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3toy MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Bradyrhizobium
sp.
ORS
278) 		4 / 5 SER A 200
GLY A 169
ASP A 217
ASP A 196
 None
None
None
CA  A 361 ( 2.9A)
 1.02A 2oxtB-3toyA:
undetectable		 2oxtB-3toyA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3toy MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Bradyrhizobium
sp.
ORS
278) 		3 / 3 LEU A  62
PRO A  61
LEU A  65
 None
 0.56A 2po7B-3toyA:
undetectable		 2po7B-3toyA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)		 3toy MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Bradyrhizobium
sp.
ORS
278) 		5 / 12 PHE A 111
GLY A 344
LEU A 345
LEU A  83
VAL A 123
 None
 0.91A 3av6A-3toyA:
undetectable		 3av6A-3toyA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_2
(PROTEIN S100-A4)		 3toy MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Bradyrhizobium
sp.
ORS
278) 		4 / 6 LEU A 107
SER A 105
ILE A  37
PHE A  52
 None
 0.84A 3ko0B-3toyA:
undetectable		 3ko0B-3toyA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_1
(PROTEIN S100-A4)		 3toy MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Bradyrhizobium
sp.
ORS
278) 		4 / 6 LEU A 107
SER A 105
ILE A  37
PHE A  52
 None
 0.91A 3ko0S-3toyA:
undetectable		 3ko0S-3toyA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)		 3toy MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Bradyrhizobium
sp.
ORS
278) 		4 / 6 LEU A 195
ALA A 206
ARG A 209
LEU A 218
 None
 1.05A 3ravA-3toyA:
undetectable		 3ravA-3toyA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		 3toy MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Bradyrhizobium
sp.
ORS
278) 		4 / 7 LEU A 152
GLY A 141
TYR A 140
SER A 139
 None
 0.98A 4cp3A-3toyA:
undetectable
4cp3B-3toyA:
undetectable		 4cp3A-3toyA:
16.89
4cp3B-3toyA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G24_A_ACAA1004_1
(PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL)		 3toy MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Bradyrhizobium
sp.
ORS
278) 		4 / 6 ALA A 103
LEU A  62
VAL A  63
ASP A  68
 None
 1.06A 4g24A-3toyA:
undetectable		 4g24A-3toyA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_2
(PROTEASE)		 3toy MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Bradyrhizobium
sp.
ORS
278) 		5 / 10 LEU A  51
ALA A  11
GLY A  70
ILE A  69
ILE A  37
 None
 1.04A 4njuB-3toyA:
undetectable		 4njuB-3toyA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_2
(PROTEASE)		 3toy MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Bradyrhizobium
sp.
ORS
278) 		5 / 10 LEU A  51
ALA A  11
GLY A  70
ILE A  69
ILE A  37
 None
 1.03A 4njuD-3toyA:
undetectable		 4njuD-3toyA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1007_1
(SERUM ALBUMIN)		 3toy MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Bradyrhizobium
sp.
ORS
278) 		5 / 9 TRP A 349
LEU A 345
LEU A 272
ILE A 278
SER A 105
 None
 1.37A 4z69A-3toyA:
undetectable		 4z69A-3toyA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CR1_A_T44A201_1
(TRANSTHYRETIN)		 3toy MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Bradyrhizobium
sp.
ORS
278) 		4 / 5 LEU A  51
ALA A  11
LEU A  62
VAL A   9
 None
 1.13A 5cr1A-3toyA:
undetectable		 5cr1A-3toyA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 3toy MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Bradyrhizobium
sp.
ORS
278) 		3 / 3 ILE A 242
PRO A 243
ILE A 221
 None
 0.45A 5hw8F-3toyA:
undetectable		 5hw8F-3toyA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3toy MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Bradyrhizobium
sp.
ORS
278) 		5 / 12 HIS A 233
GLU A 222
ARG A 237
ALA A 235
ILE A 293
 None
CA  A 361 (-3.3A)
None
None
None
 1.18A 5igvA-3toyA:
undetectable		 5igvA-3toyA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_2
(GLUCOAMYLASE P)		 3toy MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Bradyrhizobium
sp.
ORS
278) 		3 / 3 TRP A 220
GLU A 223
GLU A 318
 None
None
ACT  A 362 ( 4.7A)
 0.99A 6fhwA-3toyA:
undetectable		 6fhwA-3toyA:
11.72