SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tp2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		 3tp2 PRE-MRNA-SPLICING
FACTOR CWC2
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 209
LEU A 204
LEU A 205
 None
 0.73A 1ikeA-3tp2A:
undetectable		 1ikeA-3tp2A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		 3tp2 PRE-MRNA-SPLICING
FACTOR CWC2
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 209
LEU A 204
LEU A 205
 None
 0.72A 1np1B-3tp2A:
undetectable		 1np1B-3tp2A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_A_CUA1599_0
(NITROUS OXIDE
REDUCTASE)		 3tp2 PRE-MRNA-SPLICING
FACTOR CWC2
(Saccharomyces
cerevisiae) 		3 / 3 CYH A  81
CYH A  87
HIS A  91
 ZN  A 229 (-2.2A)
ZN  A 229 (-2.3A)
ZN  A 229 (-3.3A)
 0.86A 2iwkA-3tp2A:
undetectable		 2iwkA-3tp2A:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IWK_B_CUB1599_0
(NITROUS OXIDE
REDUCTASE)		 3tp2 PRE-MRNA-SPLICING
FACTOR CWC2
(Saccharomyces
cerevisiae) 		3 / 3 CYH A  81
CYH A  87
HIS A  91
 ZN  A 229 (-2.2A)
ZN  A 229 (-2.3A)
ZN  A 229 (-3.3A)
 0.84A 2iwkB-3tp2A:
undetectable		 2iwkB-3tp2A:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL6_A_NIMA614_1
(LACTOPEROXIDASE)		 3tp2 PRE-MRNA-SPLICING
FACTOR CWC2
(Saccharomyces
cerevisiae) 		4 / 7 GLN A  12
HIS A  58
PHE A 194
PRO A  94
 None
 1.39A 3ql6A-3tp2A:
undetectable		 3ql6A-3tp2A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_C_SVRC301_1
(NUCLEOCAPSID PROTEIN)		 3tp2 PRE-MRNA-SPLICING
FACTOR CWC2
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 140
MET A 199
PHE A 164
ILE A 160
 None
 0.89A 4j4vC-3tp2A:
undetectable		 4j4vC-3tp2A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3tp2 PRE-MRNA-SPLICING
FACTOR CWC2
(Saccharomyces
cerevisiae) 		4 / 6 PHE A 186
ILE A 170
ARG A 161
VAL A 139
 None
 1.38A 4mk4B-3tp2A:
undetectable		 4mk4B-3tp2A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGJ_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3tp2 PRE-MRNA-SPLICING
FACTOR CWC2
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 139
VAL A 223
GLN A 202
 None
 0.63A 5qgjA-3tp2A:
undetectable		 5qgjA-3tp2A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGM_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3tp2 PRE-MRNA-SPLICING
FACTOR CWC2
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 139
VAL A 223
GLN A 202
 None
 0.61A 5qgmA-3tp2A:
undetectable		 5qgmA-3tp2A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH5_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3tp2 PRE-MRNA-SPLICING
FACTOR CWC2
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 139
VAL A 223
GLN A 202
 None
 0.66A 5qh5A-3tp2A:
undetectable		 5qh5A-3tp2A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH6_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3tp2 PRE-MRNA-SPLICING
FACTOR CWC2
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 139
VAL A 223
GLN A 202
 None
 0.67A 5qh6A-3tp2A:
undetectable		 5qh6A-3tp2A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHH_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 3tp2 PRE-MRNA-SPLICING
FACTOR CWC2
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 139
VAL A 223
GLN A 202
 None
 0.68A 5qhhA-3tp2A:
undetectable		 5qhhA-3tp2A:
21.77