SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tpc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FPQ_A_SAMA1699_0
(ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE)		 3tpc SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 10 GLY A  20
LEU A  27
VAL A  34
ALA A  89
ASN A  87
 None
 1.25A 1fpqA-3tpcA:
4.8		 1fpqA-3tpcA:
23.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 3tpc SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		8 / 11 GLY A  14
SER A  17
ASP A  38
LEU A  39
ASP A  61
VAL A  62
ALA A  89
VAL A 115
 None
 0.48A 1uayA-3tpcA:
34.9		 1uayA-3tpcA:
59.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 3tpc SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		7 / 10 GLY A  14
SER A  16
LEU A  39
ASP A  61
VAL A  62
ALA A  89
VAL A 115
 None
 1.48A 1uayB-3tpcA:
35.8		 1uayB-3tpcA:
59.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 3tpc SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		8 / 10 GLY A  14
SER A  17
ASP A  38
LEU A  39
ASP A  61
VAL A  62
ALA A  89
VAL A 115
 None
 0.51A 1uayB-3tpcA:
35.8		 1uayB-3tpcA:
59.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_T_TRPT81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tpc SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 10 GLY A 143
ALA A 128
HIS A  81
ILE A 186
ALA A 127
 None
 1.18A 1utdT-3tpcA:
undetectable
1utdU-3tpcA:
undetectable		 1utdT-3tpcA:
15.08
1utdU-3tpcA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_F_SPMF1433_1
(NITROALKANE OXIDASE)		 3tpc SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 11 LEU A  35
VAL A 130
ALA A 127
LEU A 126
MET A 123
 None
 1.18A 2c12F-3tpcA:
undetectable		 2c12F-3tpcA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6002_0
(PANTOTHENATE KINASE)		 3tpc SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		4 / 8 ARG A 142
GLY A 140
ASP A 137
THR A 239
 None
 0.94A 2f9wA-3tpcA:
3.2
2f9wB-3tpcA:
3.2		 2f9wA-3tpcA:
24.17
2f9wB-3tpcA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		 3tpc SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		3 / 3 SER A  17
ASP A  38
ASN A  59
 None
 0.97A 3lslA-3tpcA:
undetectable
3lslD-3tpcA:
undetectable		 3lslA-3tpcA:
23.84
3lslD-3tpcA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_1
(FIV PROTEASE)		 3tpc SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 9 ASP A  38
GLY A  14
ILE A  11
MET A 123
GLY A 119
 None
 0.95A 3ogpA-3tpcA:
undetectable		 3ogpA-3tpcA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tpc SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 10 ALA A 127
GLY A 143
ALA A 128
HIS A  81
ILE A 186
 None
 1.09A 5eeuF-3tpcA:
undetectable
5eeuG-3tpcA:
undetectable		 5eeuF-3tpcA:
15.08
5eeuG-3tpcA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tpc SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 ALA A 127
GLY A 143
ALA A 128
HIS A  81
ILE A 186
 None
 1.10A 5eeuI-3tpcA:
undetectable
5eeuJ-3tpcA:
undetectable		 5eeuI-3tpcA:
15.08
5eeuJ-3tpcA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tpc SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 10 GLY A 143
ALA A 128
HIS A  81
ILE A 186
ALA A 127
 None
 1.17A 5eeuO-3tpcA:
undetectable
5eeuP-3tpcA:
undetectable		 5eeuO-3tpcA:
15.08
5eeuP-3tpcA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tpc SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 10 GLY A 143
ALA A 128
HIS A  81
ILE A 186
ALA A 127
 None
 1.19A 5eeuQ-3tpcA:
undetectable
5eeuR-3tpcA:
undetectable		 5eeuQ-3tpcA:
15.08
5eeuR-3tpcA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tpc SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 10 ALA A 127
GLY A 143
ALA A 128
HIS A  81
ILE A 186
 None
 1.09A 5eevF-3tpcA:
undetectable
5eevG-3tpcA:
undetectable		 5eevF-3tpcA:
15.08
5eevG-3tpcA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tpc SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 ALA A 127
GLY A 143
ALA A 128
HIS A  81
ILE A 186
 None
 1.09A 5eevI-3tpcA:
undetectable
5eevJ-3tpcA:
undetectable		 5eevI-3tpcA:
15.08
5eevJ-3tpcA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tpc SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 10 GLY A 143
ALA A 128
HIS A  81
ILE A 186
ALA A 127
 None
 1.18A 5eevQ-3tpcA:
undetectable
5eevR-3tpcA:
undetectable		 5eevQ-3tpcA:
15.08
5eevR-3tpcA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tpc SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 10 ALA A 127
GLY A 143
ALA A 128
HIS A  81
ILE A 186
 None
 1.09A 5eewF-3tpcA:
undetectable
5eewG-3tpcA:
undetectable		 5eewF-3tpcA:
15.08
5eewG-3tpcA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tpc SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 ALA A 127
GLY A 143
ALA A 128
HIS A  81
ILE A 186
 None
 1.09A 5eewI-3tpcA:
undetectable
5eewJ-3tpcA:
undetectable		 5eewI-3tpcA:
15.08
5eewJ-3tpcA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_R_TRPR101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tpc SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 10 GLY A 143
ALA A 128
HIS A  81
ILE A 186
ALA A 127
 None
 1.18A 5eewQ-3tpcA:
undetectable
5eewR-3tpcA:
undetectable		 5eewQ-3tpcA:
15.08
5eewR-3tpcA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tpc SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 10 ALA A 127
GLY A 143
ALA A 128
HIS A  81
ILE A 186
 None
 1.09A 5eexF-3tpcA:
undetectable
5eexG-3tpcA:
undetectable		 5eexF-3tpcA:
15.08
5eexG-3tpcA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tpc SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 10 ALA A 127
GLY A 143
ALA A 128
HIS A  81
ILE A 186
 None
 1.10A 5eeyF-3tpcA:
undetectable
5eeyG-3tpcA:
undetectable		 5eeyF-3tpcA:
15.08
5eeyG-3tpcA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tpc SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 10 ALA A 127
GLY A 143
ALA A 128
HIS A  81
ILE A 186
 None
 1.10A 5eezF-3tpcA:
undetectable
5eezG-3tpcA:
undetectable		 5eezF-3tpcA:
15.08
5eezG-3tpcA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tpc SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 10 ALA A 127
GLY A 143
ALA A 128
HIS A  81
ILE A 186
 None
 1.10A 5ef0F-3tpcA:
undetectable
5ef0G-3tpcA:
undetectable		 5ef0F-3tpcA:
15.08
5ef0G-3tpcA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tpc SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 10 ALA A 127
GLY A 143
ALA A 128
HIS A  81
ILE A 186
 None
 1.10A 5ef1F-3tpcA:
undetectable
5ef1G-3tpcA:
undetectable		 5ef1F-3tpcA:
15.08
5ef1G-3tpcA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tpc SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 10 ALA A 127
GLY A 143
ALA A 128
HIS A  81
ILE A 186
 None
 1.10A 5ef2F-3tpcA:
undetectable
5ef2G-3tpcA:
undetectable		 5ef2F-3tpcA:
15.08
5ef2G-3tpcA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_F_TRPF101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3tpc SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 10 ALA A 127
GLY A 143
ALA A 128
HIS A  81
ILE A 186
 None
 1.10A 5ef3F-3tpcA:
undetectable
5ef3G-3tpcA:
undetectable		 5ef3F-3tpcA:
15.08
5ef3G-3tpcA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 3tpc SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 GLY A  36
ASP A  61
VAL A  62
THR A  63
VAL A  86
 None
 1.03A 5kocA-3tpcA:
4.4		 5kocA-3tpcA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V3C_A_AMHA402_1
(QUEUINE
TRNA-RIBOSYLTRANSFER
ASE)		 3tpc SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 9 CYH A  88
GLY A  18
GLY A  20
ALA A 229
VAL A  23
 None
 1.45A 5v3cA-3tpcA:
3.7		 5v3cA-3tpcA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CK2_C_IPHC101_0
(INSULIN A CHAIN
INSULIN B CHAIN)		 3tpc SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		4 / 4 ILE A  11
LEU A  27
HIS A  83
ALA A  32
 None
 1.03A 6ck2C-3tpcA:
undetectable
6ck2D-3tpcA:
undetectable		 6ck2C-3tpcA:
5.04
6ck2D-3tpcA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J21_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 3tpc SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE
(Sinorhizobium
meliloti) 		5 / 12 ASN A  87
ILE A  11
VAL A  34
ILE A 124
VAL A  82
 None
 1.29A 6j21A-3tpcA:
undetectable		 6j21A-3tpcA:
21.84