SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tpk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_2
(POL POLYPROTEIN)		 3tpk IMMUNOGLOBULIN HEAVY
CHAIN ANTIBODY
VARIABLE DOMAIN KW1
(Camelidae) 		4 / 7 ASP A  62
VAL A  64
GLY A  50
ILE A  51
 None
 0.76A 1t7iB-3tpkA:
undetectable		 1t7iB-3tpkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_2
(POL POLYPROTEIN)		 3tpk IMMUNOGLOBULIN HEAVY
CHAIN ANTIBODY
VARIABLE DOMAIN KW1
(Camelidae) 		4 / 7 ASP A  62
VAL A  64
GLY A  50
ILE A  51
 None
 0.80A 1t7jB-3tpkA:
undetectable		 1t7jB-3tpkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_1
(PROTEASE)		 3tpk IMMUNOGLOBULIN HEAVY
CHAIN ANTIBODY
VARIABLE DOMAIN KW1
(Camelidae) 		4 / 8 ASP A  62
VAL A  64
GLY A  50
ILE A  51
 None
 0.78A 3nu9A-3tpkA:
undetectable		 3nu9A-3tpkA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 3tpk IMMUNOGLOBULIN HEAVY
CHAIN ANTIBODY
VARIABLE DOMAIN KW1
(Camelidae) 		5 / 12 VAL A   2
ALA A  24
ASN A  77
VAL A  79
ALA A  98
 None
BEN  A 133 (-3.6A)
BEN  A 133 (-3.3A)
BEN  A 133 (-4.6A)
BEN  A 133 ( 4.2A)
 0.76A 3qxtA-3tpkA:
20.9		 3qxtA-3tpkA:
64.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 3tpk IMMUNOGLOBULIN HEAVY
CHAIN ANTIBODY
VARIABLE DOMAIN KW1
(Camelidae) 		6 / 12 VAL A   2
LEU A   4
ALA A  24
VAL A  79
ALA A  98
TYR A 110
 None
BEN  A 133 (-4.7A)
BEN  A 133 (-3.6A)
BEN  A 133 (-4.6A)
BEN  A 133 ( 4.2A)
None
 0.78A 3qxtB-3tpkA:
21.0		 3qxtB-3tpkA:
64.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 3tpk IMMUNOGLOBULIN HEAVY
CHAIN ANTIBODY
VARIABLE DOMAIN KW1
(Camelidae) 		6 / 12 VAL A   2
ALA A  24
ASN A  74
VAL A  79
ALA A  98
TYR A 110
 None
BEN  A 133 (-3.6A)
None
BEN  A 133 (-4.6A)
BEN  A 133 ( 4.2A)
None
 1.30A 3qxvA-3tpkA:
20.3		 3qxvA-3tpkA:
64.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_D_MTXD2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 3tpk IMMUNOGLOBULIN HEAVY
CHAIN ANTIBODY
VARIABLE DOMAIN KW1
(Camelidae) 		5 / 12 VAL A   2
ALA A  24
VAL A  79
ALA A  98
TYR A 110
 None
BEN  A 133 (-3.6A)
BEN  A 133 (-4.6A)
BEN  A 133 ( 4.2A)
None
 0.92A 3qxvD-3tpkA:
20.3		 3qxvD-3tpkA:
64.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CJK_B_ACTB302_0
(IMMUNOGLOBULIN FAB
HEAVY CHAIN)		 3tpk IMMUNOGLOBULIN HEAVY
CHAIN ANTIBODY
VARIABLE DOMAIN KW1
(Camelidae) 		3 / 3 TYR A  60
GLY A  66
THR A  69
 None
 0.14A 6cjkB-3tpkA:
19.3		 6cjkB-3tpkA:
34.07