SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tpu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_A_CAMA503_0
(CYTOCHROME P450-CAM)		 3tpu 42F3 ALPHA
(Homo
sapiens;
Mus
musculus) 		5 / 9 TYR A  38
LEU A  46
VAL A  59
GLY A  58
ASP A  84
 None
 1.44A 1dz8A-3tpuA:
undetectable		 1dz8A-3tpuA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ8_B_CAMB502_0
(CYTOCHROME P450-CAM)		 3tpu 42F3 ALPHA
(Homo
sapiens;
Mus
musculus) 		5 / 9 TYR A  38
LEU A  46
VAL A  59
GLY A  58
ASP A  84
 None
 1.44A 1dz8B-3tpuA:
undetectable		 1dz8B-3tpuA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_B_CAMB502_0
(CYTOCHROME P450-CAM)		 3tpu 42F3 ALPHA
(Homo
sapiens;
Mus
musculus) 		5 / 9 TYR A  38
LEU A  46
VAL A  59
GLY A  58
ASP A  84
 None
 1.44A 1dz9B-3tpuA:
undetectable		 1dz9B-3tpuA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_B_BEZB1503_0
(RAS-RELATED PROTEIN
RAB-9A)		 3tpu 42F3 BETA
(Homo
sapiens;
Mus
musculus) 		4 / 6 VAL B  14
THR B  15
GLU B 112
LEU B 114
 None
 1.13A 1s8fB-3tpuB:
undetectable		 1s8fB-3tpuB:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_C_ADNC903_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 3tpu 42F3 ALPHA
42F3 BETA
(Homo
sapiens;
Mus
musculus) 		5 / 12 ALA B 234
VAL B 193
HIS B 204
PHE B 205
SER A 128
 None
None
SO4  B 243 (-3.9A)
None
None
 1.35A 2gl0A-3tpuB:
undetectable
2gl0C-3tpuB:
undetectable		 2gl0A-3tpuB:
20.52
2gl0C-3tpuB:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_2
(ADENOSYLHOMOCYSTEINA
SE)		 3tpu 42F3 ALPHA
42F3 BETA
(Homo
sapiens;
Mus
musculus) 		4 / 5 GLN A 124
GLU B 131
THR B 135
HIS B 134
 None
 1.37A 3glqB-3tpuA:
undetectable		 3glqB-3tpuA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3tpu 42F3 BETA
(Homo
sapiens;
Mus
musculus) 		3 / 3 TYR B  48
GLY B  58
ASP B  59
 None
 0.57A 3ou6C-3tpuB:
undetectable		 3ou6C-3tpuB:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1006_1
(SERUM ALBUMIN)		 3tpu 42F3 BETA
(Homo
sapiens;
Mus
musculus) 		4 / 7 ILE B  46
HIS B  47
LEU B  76
GLY B  63
 None
 1.05A 4z69A-3tpuB:
undetectable		 4z69A-3tpuB:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 3tpu 42F3 ALPHA
42F3 BETA
(Homo
sapiens;
Mus
musculus) 		4 / 5 TYR B  50
GLY A  96
TYR B  31
GLY B  98
 None
 0.74A 5ayfA-3tpuB:
undetectable		 5ayfA-3tpuB:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3tpu 42F3 BETA
(Homo
sapiens;
Mus
musculus) 		4 / 7 TYR B  64
GLY B  17
THR B  13
LEU B 108
 None
 1.01A 5esmA-3tpuB:
undetectable		 5esmA-3tpuB:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_I_BEZI1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 3tpu 42F3 ALPHA
(Homo
sapiens;
Mus
musculus) 		3 / 3 SER A  51
TYR A  50
TYR A  49
 None
 0.63A 5lakA-3tpuA:
undetectable
5lakI-3tpuA:
undetectable		 5lakA-3tpuA:
21.36
5lakI-3tpuA:
3.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_J_BEZJ1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 3tpu 42F3 ALPHA
(Homo
sapiens;
Mus
musculus) 		3 / 3 SER A  51
TYR A  50
TYR A  49
 None
 0.51A 5lakC-3tpuA:
undetectable
5lakJ-3tpuA:
undetectable		 5lakC-3tpuA:
21.36
5lakJ-3tpuA:
3.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_E_SAME501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3tpu 42F3 ALPHA
(Homo
sapiens;
Mus
musculus) 		5 / 9 HIS A  81
GLY A  61
SER A  85
LEU A  18
ARG A  76
 None
 1.31A 5o96E-3tpuA:
undetectable
5o96F-3tpuA:
undetectable		 5o96E-3tpuA:
20.54
5o96F-3tpuA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6M_A_SALA503_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 3tpu 42F3 ALPHA
42F3 BETA
(Homo
sapiens;
Mus
musculus) 		4 / 7 THR B 135
PHE A 170
GLN A 116
MET A 165
 None
 1.42A 5u6mA-3tpuB:
undetectable		 5u6mA-3tpuB:
19.33