SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3tqc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1SQ5_A_PAUA6001_0
(PANTOTHENATE KINASE)		 3tqc PANTOTHENATE KINASE
(Coxiella
burnetii) 		9 / 9 ASP A 128
LEU A 131
LYS A 146
GLY A 147
HIS A 178
LEU A 202
TYR A 241
ILE A 282
ASN A 283
 None
 0.72A 1sq5A-3tqcA:
41.1		 1sq5A-3tqcA:
52.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1SQ5_B_PAUB6003_0
(PANTOTHENATE KINASE)		 3tqc PANTOTHENATE KINASE
(Coxiella
burnetii) 		10 / 10 ASP A 128
LEU A 131
LYS A 146
GLY A 147
HIS A 178
TYR A 181
LEU A 202
TYR A 241
ILE A 282
ASN A 283
 None
 0.73A 1sq5B-3tqcA:
41.2		 1sq5B-3tqcA:
52.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1SQ5_C_PAUC6002_0
(PANTOTHENATE KINASE)		 3tqc PANTOTHENATE KINASE
(Coxiella
burnetii) 		9 / 9 ASP A 128
LEU A 131
LYS A 146
GLY A 147
HIS A 178
LEU A 202
TYR A 241
ILE A 282
ASN A 283
 None
 0.73A 1sq5C-3tqcA:
40.4		 1sq5C-3tqcA:
52.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1SQ5_D_PAUD6004_0
(PANTOTHENATE KINASE)		 3tqc PANTOTHENATE KINASE
(Coxiella
burnetii) 		10 / 10 VAL A  98
ASP A 128
LEU A 131
LYS A 146
GLY A 147
HIS A 178
LEU A 202
TYR A 241
ILE A 282
ASN A 283
 ADP  A 500 ( 4.4A)
None
None
None
None
None
None
None
None
None
 0.69A 1sq5D-3tqcA:
41.2		 1sq5D-3tqcA:
52.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZS9_A_PAUA603_0
(PANTOTHENATE KINASE)		 3tqc PANTOTHENATE KINASE
(Coxiella
burnetii) 		5 / 6 VAL A  98
ASP A 128
LYS A 146
HIS A 178
TYR A 181
 ADP  A 500 ( 4.4A)
None
None
None
None
 0.66A 2zs9A-3tqcA:
37.5		 2zs9A-3tqcA:
51.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZS9_A_PAUA603_0
(PANTOTHENATE KINASE)		 3tqc PANTOTHENATE KINASE
(Coxiella
burnetii) 		5 / 6 VAL A  98
LYS A 146
HIS A 178
TYR A 181
ASN A 283
 ADP  A 500 ( 4.4A)
None
None
None
None
 0.43A 2zs9A-3tqcA:
37.5		 2zs9A-3tqcA:
51.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUH_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 3tqc PANTOTHENATE KINASE
(Coxiella
burnetii) 		4 / 6 THR A 127
LEU A 157
VAL A 160
VAL A 197
 None
 1.08A 2zuhA-3tqcA:
undetectable		 2zuhA-3tqcA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUI_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 3tqc PANTOTHENATE KINASE
(Coxiella
burnetii) 		4 / 6 THR A 127
LEU A 157
VAL A 160
VAL A 197
 None
 1.08A 2zuiA-3tqcA:
undetectable		 2zuiA-3tqcA:
20.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AF0_A_PAUA314_0
(PANTOTHENATE KINASE)		 3tqc PANTOTHENATE KINASE
(Coxiella
burnetii) 		8 / 8 VAL A  98
ASP A 128
LEU A 131
LYS A 146
GLY A 147
TYR A 152
HIS A 178
TYR A 181
 ADP  A 500 ( 4.4A)
None
None
None
None
None
None
None
 0.58A 3af0A-3tqcA:
37.6		 3af0A-3tqcA:
51.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AVO_A_PAUA314_0
(PANTOTHENATE KINASE)		 3tqc PANTOTHENATE KINASE
(Coxiella
burnetii) 		10 / 11 VAL A  98
ASP A 128
LEU A 131
LYS A 146
TYR A 152
TYR A 176
HIS A 178
TYR A 181
PHE A 260
ILE A 282
 ADP  A 500 ( 4.4A)
None
None
None
None
None
None
None
None
None
 0.66A 3avoA-3tqcA:
37.4		 3avoA-3tqcA:
51.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AVO_A_PAUA314_0
(PANTOTHENATE KINASE)		 3tqc PANTOTHENATE KINASE
(Coxiella
burnetii) 		10 / 11 VAL A  98
LEU A 131
LYS A 146
TYR A 152
TYR A 176
HIS A 178
TYR A 181
PHE A 260
ILE A 282
ASN A 283
 ADP  A 500 ( 4.4A)
None
None
None
None
None
None
None
None
None
 0.57A 3avoA-3tqcA:
37.4		 3avoA-3tqcA:
51.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AVP_A_MV2A313_1
(PANTOTHENATE KINASE)		 3tqc PANTOTHENATE KINASE
(Coxiella
burnetii) 		4 / 7 VAL A  98
ASP A 128
HIS A 178
LEU A 202
 ADP  A 500 ( 4.4A)
None
None
None
 0.89A 3avpA-3tqcA:
37.3		 3avpA-3tqcA:
51.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AVP_A_MV2A313_1
(PANTOTHENATE KINASE)		 3tqc PANTOTHENATE KINASE
(Coxiella
burnetii) 		4 / 7 VAL A  98
HIS A 178
LEU A 202
ASN A 283
 ADP  A 500 ( 4.4A)
None
None
None
 0.69A 3avpA-3tqcA:
37.3		 3avpA-3tqcA:
51.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AVP_A_MV2A313_1
(PANTOTHENATE KINASE)		 3tqc PANTOTHENATE KINASE
(Coxiella
burnetii) 		4 / 7 VAL A  98
LEU A 202
TYR A 241
ASN A 283
 ADP  A 500 ( 4.4A)
None
None
None
 0.37A 3avpA-3tqcA:
37.3		 3avpA-3tqcA:
51.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FXR_A_ASCA3001_0
(LYSR TYPE REGULATOR
OF TSAMBCD)		 3tqc PANTOTHENATE KINASE
(Coxiella
burnetii) 		4 / 8 ALA A 163
ILE A 164
PRO A  89
PRO A 194
 None
 0.89A 3fxrA-3tqcA:
undetectable		 3fxrA-3tqcA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 3tqc PANTOTHENATE KINASE
(Coxiella
burnetii) 		3 / 3 PHE A 229
TYR A 294
LEU A 315
 None
 0.79A 3sueB-3tqcA:
undetectable		 3sueB-3tqcA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_D_9PLD1_1
(CYTOCHROME P450 2A13)		 3tqc PANTOTHENATE KINASE
(Coxiella
burnetii) 		4 / 8 PHE A 260
PHE A 253
PHE A 274
ALA A 275
 None
 0.86A 3t3sD-3tqcA:
undetectable		 3t3sD-3tqcA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EF6_A_BEZA401_0
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3tqc PANTOTHENATE KINASE
(Coxiella
burnetii) 		5 / 9 LEU A 161
ILE A  91
PRO A  89
VAL A 197
ILE A 164
 None
 1.26A 6ef6A-3tqcA:
undetectable		 6ef6A-3tqcA:
20.97